Gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant) Gene Set

Dataset CORUM Protein Complexes
Category structural or functional annotations
Type protein complex
Description A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein. (Gene Ontology, GO_0070765)
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4 proteins in the Gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant) protein complex from the CORUM Protein Complexes dataset.

Symbol Name
APH1A APH1A gamma secretase subunit
NCSTN nicastrin
PSEN1 presenilin 1
PSENEN presenilin enhancer gamma secretase subunit