Gamma-hydroxybutyric acidaemia_CNS - Brain - Hippocampus (MMHCC)_GSE2866 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Diseases
Category transcriptomics
Type disease perturbation
Description disease perturbation identified as [disease]_[tissue]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2866
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Genes

600 genes differentially expressed during Gamma-hydroxybutyric acidaemia_CNS - Brain - Hippocampus (MMHCC)_GSE2866 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.

increased expression

Symbol Name Standardized Value
MAP3K3 mitogen-activated protein kinase kinase kinase 3 3.33053
LARS leucyl-tRNA synthetase 3.2757
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 3.23461
RRAGC Ras-related GTP binding C 3.15554
ARL14EP ADP-ribosylation factor-like 14 effector protein 3.1498
PSPH phosphoserine phosphatase 3.10781
RPUSD4 RNA pseudouridylate synthase domain containing 4 3.08248
TMEM205 transmembrane protein 205 2.92572
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) 2.92
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.86638
POLM polymerase (DNA directed), mu 2.83541
ACOT13 acyl-CoA thioesterase 13 2.69036
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 2.68917
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) 2.65682
SBF2 SET binding factor 2 2.59249
RAD23B RAD23 homolog B (S. cerevisiae) 2.57742
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 2.57305
SCARB2 scavenger receptor class B, member 2 2.5503
RPS5 ribosomal protein S5 2.53538
RAB33B RAB33B, member RAS oncogene family 2.53347
SRSF10 serine/arginine-rich splicing factor 10 2.52651
RAB5C RAB5C, member RAS oncogene family 2.52277
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 2.49864
FAM32A family with sequence similarity 32, member A 2.4731
ALAS1 5'-aminolevulinate synthase 1 2.47023
NUDCD2 NudC domain containing 2 2.4526
SCAMP1 secretory carrier membrane protein 1 2.44924
ASRGL1 asparaginase like 1 2.44524
PPP1R18 protein phosphatase 1, regulatory subunit 18 2.4231
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 2.42079
HDLBP high density lipoprotein binding protein 2.40857
STK40 serine/threonine kinase 40 2.40852
ZNF362 zinc finger protein 362 2.40515
PNPLA2 patatin-like phospholipase domain containing 2 2.39062
TNIP1 TNFAIP3 interacting protein 1 2.38587
DHRSX dehydrogenase/reductase (SDR family) X-linked 2.38273
YARS tyrosyl-tRNA synthetase 2.37939
ZNF688 zinc finger protein 688 2.37662
TM9SF1 transmembrane 9 superfamily member 1 2.3608
HS1BP3 HCLS1 binding protein 3 2.35587
RPAP1 RNA polymerase II associated protein 1 2.33628
CANT1 calcium activated nucleotidase 1 2.32837
PNRC1 proline-rich nuclear receptor coactivator 1 2.32296
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 2.30628
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 2.29848
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 2.29496
SIN3A SIN3 transcription regulator family member A 2.29248
METTL8 methyltransferase like 8 2.28573
BAD BCL2-associated agonist of cell death 2.2634
MBD2 methyl-CpG binding domain protein 2 2.25705
MEF2A myocyte enhancer factor 2A 2.25325
COQ3 coenzyme Q3 methyltransferase 2.24679
RPA2 replication protein A2, 32kDa 2.24146
INPP5F inositol polyphosphate-5-phosphatase F 2.23998
UFD1L ubiquitin fusion degradation 1 like (yeast) 2.23951
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 2.2368
SLC19A1 solute carrier family 19 (folate transporter), member 1 2.23564
FKBP7 FK506 binding protein 7 2.23155
SURF1 surfeit 1 2.22007
PON2 paraoxonase 2 2.21103
GNG12 guanine nucleotide binding protein (G protein), gamma 12 2.20958
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 2.20304
PITHD1 PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1 2.19851
IGBP1 immunoglobulin (CD79A) binding protein 1 2.1918
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 2.18499
PNRC2 proline-rich nuclear receptor coactivator 2 2.17789
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) 2.17712
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.1607
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 2.15651
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 2.14736
PPP6R3 protein phosphatase 6, regulatory subunit 3 2.133
SOX18 SRY (sex determining region Y)-box 18 2.12579
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) 2.125
TMEM106C transmembrane protein 106C 2.12019
RSL1D1 ribosomal L1 domain containing 1 2.11891
SDHAF2 succinate dehydrogenase complex assembly factor 2 2.1176
GJB2 gap junction protein, beta 2, 26kDa 2.11194
ZFP36L1 ZFP36 ring finger protein-like 1 2.11078
TPP1 tripeptidyl peptidase I 2.10971
C11ORF58 chromosome 11 open reading frame 58 2.10909
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 2.10834
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 2.09566
MRPL3 mitochondrial ribosomal protein L3 2.08594
RAB11A RAB11A, member RAS oncogene family 2.08211
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 2.0805
RBBP6 retinoblastoma binding protein 6 2.07232
AQR aquarius intron-binding spliceosomal factor 2.05897
EXOC7 exocyst complex component 7 2.05244
UBE2F ubiquitin-conjugating enzyme E2F (putative) 2.05239
CTSA cathepsin A 2.04852
TMEM222 transmembrane protein 222 2.03914
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 2.03478
PSMG4 proteasome (prosome, macropain) assembly chaperone 4 2.03043
TOP1 topoisomerase (DNA) I 2.02859
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2 2.02441
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) 2.02352
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) 2.01337
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 2.0102
ARL8B ADP-ribosylation factor-like 8B 2.00926
MEF2D myocyte enhancer factor 2D 2.00461
BCL2L13 BCL2-like 13 (apoptosis facilitator) 2.00429
ATG4B autophagy related 4B, cysteine peptidase 2.00226
CAMK2N2 calcium/calmodulin-dependent protein kinase II inhibitor 2 2.00203
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 1.99821
ATOX1 antioxidant 1 copper chaperone 1.99567
IPO8 importin 8 1.99476
RFC2 replication factor C (activator 1) 2, 40kDa 1.99201
PCID2 PCI domain containing 2 1.97595
ATF5 activating transcription factor 5 1.96785
CDC37 cell division cycle 37 1.96584
PARG poly (ADP-ribose) glycohydrolase 1.96528
HP haptoglobin 1.96128
COMMD7 COMM domain containing 7 1.96023
TRAFD1 TRAF-type zinc finger domain containing 1 1.9554
CYBA cytochrome b-245, alpha polypeptide 1.95131
PITPNB phosphatidylinositol transfer protein, beta 1.94508
NFXL1 nuclear transcription factor, X-box binding-like 1 1.94296
HAUS8 HAUS augmin-like complex, subunit 8 1.93974
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 1.933
RPL10A ribosomal protein L10a 1.92701
HINT2 histidine triad nucleotide binding protein 2 1.92292
TMEM179B transmembrane protein 179B 1.91473
PNP purine nucleoside phosphorylase 1.91229
CERCAM cerebral endothelial cell adhesion molecule 1.90432
RAB9A RAB9A, member RAS oncogene family 1.89665
GPR162 G protein-coupled receptor 162 1.8945
CPD carboxypeptidase D 1.89184
PEX5 peroxisomal biogenesis factor 5 1.89179
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit 1.88915
REXO1 REX1, RNA exonuclease 1 homolog (S. cerevisiae) 1.87394
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 1.86345
TMEM5 transmembrane protein 5 1.86076
SEC24C SEC24 family member C 1.85947
LAT linker for activation of T cells 1.85654
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 1.85226
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 1.8512
DRG1 developmentally regulated GTP binding protein 1 1.84801
PITPNA phosphatidylinositol transfer protein, alpha 1.84631
CD320 CD320 molecule 1.84379
INO80C INO80 complex subunit C 1.83567
TMOD3 tropomodulin 3 (ubiquitous) 1.83389
CDK8 cyclin-dependent kinase 8 1.83252
PURB purine-rich element binding protein B 1.82958
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 1.82551
NFE2L2 nuclear factor, erythroid 2-like 2 1.82272
AGTRAP angiotensin II receptor-associated protein 1.82159
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) 1.82065
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 1.81975
ZZZ3 zinc finger, ZZ-type containing 3 1.81795
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) 1.81696
FAM50A family with sequence similarity 50, member A 1.8132
RPL7L1 ribosomal protein L7-like 1 1.81168
SAMM50 SAMM50 sorting and assembly machinery component 1.80874
PHF1 PHD finger protein 1 1.80837
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa 1.8071
IL10RB interleukin 10 receptor, beta 1.80169
EGFR epidermal growth factor receptor 1.79901
RPS19 ribosomal protein S19 1.79817
CDC26 cell division cycle 26 1.79045
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1.78788
GPI glucose-6-phosphate isomerase 1.78561
DYNLRB1 dynein, light chain, roadblock-type 1 1.7771
ANXA3 annexin A3 1.77548
MRPL45 mitochondrial ribosomal protein L45 1.77192
WDR45 WD repeat domain 45 1.76834
SF3B2 splicing factor 3b, subunit 2, 145kDa 1.765
TGIF1 TGFB-induced factor homeobox 1 1.76468
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 1.75942
DUSP8 dual specificity phosphatase 8 1.75937
TMEM43 transmembrane protein 43 1.75239
ZMYM4 zinc finger, MYM-type 4 1.74829
NCOA1 nuclear receptor coactivator 1 1.7412
LAMP2 lysosomal-associated membrane protein 2 1.7327
RAD1 RAD1 checkpoint DNA exonuclease 1.7326
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 1.73245
ZFP36L2 ZFP36 ring finger protein-like 2 1.73056
ACP1 acid phosphatase 1, soluble 1.72916
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 1.72915
SP1 Sp1 transcription factor 1.72613
DGCR14 DiGeorge syndrome critical region gene 14 1.72597
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 1.7244
COX4I1 cytochrome c oxidase subunit IV isoform 1 1.72396
STX2 syntaxin 2 1.72267
WNK2 WNK lysine deficient protein kinase 2 1.7188
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 1.71694
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 1.71641
CTSB cathepsin B 1.71634
EFTUD1 elongation factor Tu GTP binding domain containing 1 1.71425
UGDH UDP-glucose 6-dehydrogenase 1.71331
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 1.71268
USF1 upstream transcription factor 1 1.7116
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 1.71142
PIH1D1 PIH1 domain containing 1 1.70513
KIAA0319L KIAA0319-like 1.70506
RB1 retinoblastoma 1 1.70116
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 1.69878
BABAM1 BRISC and BRCA1 A complex member 1 1.68812
NARS asparaginyl-tRNA synthetase 1.68614
C1ORF174 chromosome 1 open reading frame 174 1.68603
SUMO3 small ubiquitin-like modifier 3 1.6858
TUBB6 tubulin, beta 6 class V 1.68274
TFCP2 transcription factor CP2 1.68236
RPS27A ribosomal protein S27a 1.678
SARDH sarcosine dehydrogenase 1.67683
BAAT bile acid CoA:amino acid N-acyltransferase 1.67495
EYA1 EYA transcriptional coactivator and phosphatase 1 1.67322
FBXO6 F-box protein 6 1.66896
WDR81 WD repeat domain 81 1.66566
SMAD5 SMAD family member 5 1.66037
CEP350 centrosomal protein 350kDa 1.65849
SPATA6 spermatogenesis associated 6 1.65783
YIPF3 Yip1 domain family, member 3 1.65717
RABGGTB Rab geranylgeranyltransferase, beta subunit 1.65508
NFE2L1 nuclear factor, erythroid 2-like 1 1.65462
ATE1 arginyltransferase 1 1.6511
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 1.64346
DMAP1 DNA methyltransferase 1 associated protein 1 1.64229
TMUB2 transmembrane and ubiquitin-like domain containing 2 1.64199
ARL3 ADP-ribosylation factor-like 3 1.63967
ACADL acyl-CoA dehydrogenase, long chain 1.63387
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 1.63271
CREB3L1 cAMP responsive element binding protein 3-like 1 1.63145
CCT2 chaperonin containing TCP1, subunit 2 (beta) 1.63134
CYTH3 cytohesin 3 1.62926
DFNA5 deafness, autosomal dominant 5 1.62863
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa 1.6285
GALR3 galanin receptor 3 1.62665
NMD3 NMD3 ribosome export adaptor 1.62435
NOP2 NOP2 nucleolar protein 1.62355
ARNTL aryl hydrocarbon receptor nuclear translocator-like 1.62126
IL6ST interleukin 6 signal transducer 1.61775
PGM2 phosphoglucomutase 2 1.6131
UBA3 ubiquitin-like modifier activating enzyme 3 1.6052
TXNDC16 thioredoxin domain containing 16 1.60472
EXOSC5 exosome component 5 1.6045
PEX14 peroxisomal biogenesis factor 14 1.60445
S100A6 S100 calcium binding protein A6 1.60194
IFRD2 interferon-related developmental regulator 2 1.60109
USP8 ubiquitin specific peptidase 8 1.59791
SNX12 sorting nexin 12 1.59412
GTPBP1 GTP binding protein 1 1.58985
PTPRA protein tyrosine phosphatase, receptor type, A 1.58809
TERF2 telomeric repeat binding factor 2 1.58539
SLC25A47 solute carrier family 25, member 47 1.58528
IST1 increased sodium tolerance 1 homolog (yeast) 1.5827
MRPS18A mitochondrial ribosomal protein S18A 1.57893
SARS seryl-tRNA synthetase 1.57582
N4BP1 NEDD4 binding protein 1 1.5756
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 1.57498
REPS1 RALBP1 associated Eps domain containing 1 1.57452
IGF1R insulin-like growth factor 1 receptor 1.57303
OSMR oncostatin M receptor 1.56863
CAT catalase 1.56815
PEBP1 phosphatidylethanolamine binding protein 1 1.56392
PAIP2B poly(A) binding protein interacting protein 2B 1.5626
EPHA3 EPH receptor A3 1.55852
BCAP29 B-cell receptor-associated protein 29 1.55469
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 1.55271
GSTZ1 glutathione S-transferase zeta 1 1.55213
CYHR1 cysteine/histidine-rich 1 1.55161
KIF1B kinesin family member 1B 1.55138
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 1.55089
RPL8 ribosomal protein L8 1.5501
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.5455
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 1.5455
MGST1 microsomal glutathione S-transferase 1 1.54537
TMEM109 transmembrane protein 109 1.54421
MRPS14 mitochondrial ribosomal protein S14 1.54378
BLZF1 basic leucine zipper nuclear factor 1 1.54322
GDF9 growth differentiation factor 9 1.54303
SEC11C SEC11 homolog C (S. cerevisiae) 1.54207
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 1.5412
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant 1.54101
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 1.54051
HMOX1 heme oxygenase 1 1.53897
DLK1 delta-like 1 homolog (Drosophila) 1.5343
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 1.5329
USP10 ubiquitin specific peptidase 10 1.53229
MFAP5 microfibrillar associated protein 5 1.53228
NTPCR nucleoside-triphosphatase, cancer-related 1.53026
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 1.5294
BAX BCL2-associated X protein 1.52684
XPO7 exportin 7 1.52392
XPR1 xenotropic and polytropic retrovirus receptor 1 1.52368
INVS inversin 1.52138
UBL5 ubiquitin-like 5 1.52131
S100PBP S100P binding protein 1.51831
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) 1.51683
RAD51AP1 RAD51 associated protein 1 1.51473
SVIL supervillin 1.51469
PTGES prostaglandin E synthase 1.51418
RANBP10 RAN binding protein 10 1.5128
ASNA1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) 1.51111
IKZF4 IKAROS family zinc finger 4 (Eos) 1.50434
TPR translocated promoter region, nuclear basket protein 1.50309
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.50118
MRPL33 mitochondrial ribosomal protein L33 1.50016
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 1.49866
DDIT3 DNA-damage-inducible transcript 3 1.49858
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.49816

decreased expression

Symbol Name Standardized Value
PRDX3 peroxiredoxin 3 -4.17887
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) -3.41759
ETHE1 ethylmalonic encephalopathy 1 -3.20426
UBE2Z ubiquitin-conjugating enzyme E2Z -3.19989
TP53INP2 tumor protein p53 inducible nuclear protein 2 -3.17071
SNX3 sorting nexin 3 -3.01582
MRPL43 mitochondrial ribosomal protein L43 -2.94829
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 -2.93654
CS citrate synthase -2.8428
COPS3 COP9 signalosome subunit 3 -2.83516
SEC13 SEC13 homolog (S. cerevisiae) -2.80735
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 -2.78115
VEGFB vascular endothelial growth factor B -2.75687
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -2.7493
MRPL37 mitochondrial ribosomal protein L37 -2.69251
CHGA chromogranin A -2.65874
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -2.61214
CCT3 chaperonin containing TCP1, subunit 3 (gamma) -2.59654
MRPS18B mitochondrial ribosomal protein S18B -2.57644
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -2.56904
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa -2.54926
PGAM1 phosphoglycerate mutase 1 (brain) -2.53835
GAMT guanidinoacetate N-methyltransferase -2.51707
MRPL16 mitochondrial ribosomal protein L16 -2.51349
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta -2.49789
TEN1 TEN1 CST complex subunit -2.46072
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) -2.43128
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae) -2.42916
ACO2 aconitase 2, mitochondrial -2.41117
SRXN1 sulfiredoxin 1 -2.37277
EVL Enah/Vasp-like -2.36589
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) -2.35578
TRAPPC1 trafficking protein particle complex 1 -2.34831
TRAPPC4 trafficking protein particle complex 4 -2.3217
TEX264 testis expressed 264 -2.31649
GAPDH glyceraldehyde-3-phosphate dehydrogenase -2.31445
FN1 fibronectin 1 -2.30865
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 -2.29819
RBM42 RNA binding motif protein 42 -2.28867
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -2.28134
DPP8 dipeptidyl-peptidase 8 -2.27853
PKM pyruvate kinase, muscle -2.2744
POLR2M polymerase (RNA) II (DNA directed) polypeptide M -2.25845
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 -2.24759
INTS3 integrator complex subunit 3 -2.2391
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) -2.22103
RAB28 RAB28, member RAS oncogene family -2.21459
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.20236
AZIN1 antizyme inhibitor 1 -2.18539
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 -2.1842
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast) -2.17869
MORF4L2 mortality factor 4 like 2 -2.17064
FAM73B family with sequence similarity 73, member B -2.14595
BZW1 basic leucine zipper and W2 domains 1 -2.14013
PPA1 pyrophosphatase (inorganic) 1 -2.13783
DDHD2 DDHD domain containing 2 -2.13394
TMEM183A transmembrane protein 183A -2.1299
HES2 hes family bHLH transcription factor 2 -2.12507
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle -2.12214
PRDX5 peroxiredoxin 5 -2.09863
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 -2.09757
PAQR7 progestin and adipoQ receptor family member VII -2.0833
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) -2.08038
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 -2.07794
SGK1 serum/glucocorticoid regulated kinase 1 -2.07578
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.06335
HIPK2 homeodomain interacting protein kinase 2 -2.05866
PRDX1 peroxiredoxin 1 -2.04821
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.03919
HSPA8 heat shock 70kDa protein 8 -2.02876
DOHH deoxyhypusine hydroxylase/monooxygenase -2.02612
TMEM9B TMEM9 domain family, member B -2.02386
C6ORF136 chromosome 6 open reading frame 136 -2.01491
KPNA1 karyopherin alpha 1 (importin alpha 5) -2.01194
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.01141
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.00075
ERBB3 erb-b2 receptor tyrosine kinase 3 -1.99499
TSC22D1 TSC22 domain family, member 1 -1.98264
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -1.98173
YIPF4 Yip1 domain family, member 4 -1.97711
NPC1 Niemann-Pick disease, type C1 -1.9748
TTC33 tetratricopeptide repeat domain 33 -1.96146
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -1.96059
MRPL24 mitochondrial ribosomal protein L24 -1.95681
CFL1 cofilin 1 (non-muscle) -1.94662
SAR1A secretion associated, Ras related GTPase 1A -1.91221
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 -1.90552
NCOA5 nuclear receptor coactivator 5 -1.90364
ELOVL6 ELOVL fatty acid elongase 6 -1.89883
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -1.89687
CUL3 cullin 3 -1.8827
HIGD2A HIG1 hypoxia inducible domain family, member 2A -1.88185
LMF1 lipase maturation factor 1 -1.88147
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -1.88107
SRM spermidine synthase -1.87988
HDAC5 histone deacetylase 5 -1.87984
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 -1.87502
KLF13 Kruppel-like factor 13 -1.86504
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -1.86117
EEF2 eukaryotic translation elongation factor 2 -1.86091
KCTD17 potassium channel tetramerization domain containing 17 -1.85188
WDR43 WD repeat domain 43 -1.84948
PRKCSH protein kinase C substrate 80K-H -1.84709
TRIM13 tripartite motif containing 13 -1.84684
UBC ubiquitin C -1.84445
SCAMP3 secretory carrier membrane protein 3 -1.84315
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) -1.83755
WBP1 WW domain binding protein 1 -1.81863
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta -1.81755
MRPL48 mitochondrial ribosomal protein L48 -1.80862
TUBB4A tubulin, beta 4A class IVa -1.8045
CCT7 chaperonin containing TCP1, subunit 7 (eta) -1.80444
PGK1 phosphoglycerate kinase 1 -1.80416
DHCR7 7-dehydrocholesterol reductase -1.79963
FBXL3 F-box and leucine-rich repeat protein 3 -1.79413
TUSC2 tumor suppressor candidate 2 -1.79411
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) -1.79011
IDI1 isopentenyl-diphosphate delta isomerase 1 -1.78982
CYC1 cytochrome c-1 -1.788
LPAR1 lysophosphatidic acid receptor 1 -1.78767
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -1.77997
ENO2 enolase 2 (gamma, neuronal) -1.77579
NDRG1 N-myc downstream regulated 1 -1.77541
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) -1.77002
TMEM246 transmembrane protein 246 -1.75999
GOLPH3 golgi phosphoprotein 3 (coat-protein) -1.75871
SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase -1.75499
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 -1.75394
NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae) -1.75173
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme -1.75115
MARCH5 membrane-associated ring finger (C3HC4) 5 -1.74127
ANAPC1 anaphase promoting complex subunit 1 -1.73853
UBTF upstream binding transcription factor, RNA polymerase I -1.73173
ERRFI1 ERBB receptor feedback inhibitor 1 -1.72774
SLBP stem-loop binding protein -1.72344
HSPA4L heat shock 70kDa protein 4-like -1.72291
TMEM14C transmembrane protein 14C -1.71287
SMYD2 SET and MYND domain containing 2 -1.71016
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 -1.70464
HTRA1 HtrA serine peptidase 1 -1.70193
ZDHHC3 zinc finger, DHHC-type containing 3 -1.69608
WIZ widely interspaced zinc finger motifs -1.69591
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 -1.69469
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 -1.6911
CSNK1G2 casein kinase 1, gamma 2 -1.6901
RNF5 ring finger protein 5, E3 ubiquitin protein ligase -1.68668
KANSL2 KAT8 regulatory NSL complex subunit 2 -1.68501
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa -1.68489
LAMP1 lysosomal-associated membrane protein 1 -1.67926
OTUD7B OTU deubiquitinase 7B -1.67837
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like -1.67758
ANKRD13C ankyrin repeat domain 13C -1.67522
RHOU ras homolog family member U -1.66833
TPT1 tumor protein, translationally-controlled 1 -1.66763
C19ORF60 chromosome 19 open reading frame 60 -1.66261
HSCB HscB mitochondrial iron-sulfur cluster co-chaperone -1.66088
NUDT16L1 nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1 -1.65903
UFC1 ubiquitin-fold modifier conjugating enzyme 1 -1.65219
PUM2 pumilio RNA-binding family member 2 -1.65083
WDR92 WD repeat domain 92 -1.64656
LEPROT leptin receptor overlapping transcript -1.63883
PTDSS1 phosphatidylserine synthase 1 -1.63408
MBP myelin basic protein -1.6319
PEX6 peroxisomal biogenesis factor 6 -1.63169
GPS1 G protein pathway suppressor 1 -1.62271
SLC25A19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 -1.62214
AATK apoptosis-associated tyrosine kinase -1.61952
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -1.61926
MRPS7 mitochondrial ribosomal protein S7 -1.61678
INA internexin neuronal intermediate filament protein, alpha -1.6106
TUBA1A tubulin, alpha 1a -1.60631
PROSC proline synthetase co-transcribed homolog (bacterial) -1.60327
TMEM176B transmembrane protein 176B -1.60248
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa -1.60027
OSBP oxysterol binding protein -1.59397
TMEM70 transmembrane protein 70 -1.58353
SPPL3 signal peptide peptidase like 3 -1.58108
FXN frataxin -1.58066
USP21 ubiquitin specific peptidase 21 -1.57772
MTA2 metastasis associated 1 family, member 2 -1.57326
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa -1.5724
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha -1.57041
SPEF1 sperm flagellar 1 -1.56387
B9D1 B9 protein domain 1 -1.55596
MRPS25 mitochondrial ribosomal protein S25 -1.55319
CLDND1 claudin domain containing 1 -1.55168
TMEM68 transmembrane protein 68 -1.5489
TXN2 thioredoxin 2 -1.54726
LTBP4 latent transforming growth factor beta binding protein 4 -1.54637
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa -1.54608
EGLN2 egl-9 family hypoxia-inducible factor 2 -1.54372
PHB2 prohibitin 2 -1.54267
SLC22A23 solute carrier family 22, member 23 -1.54261
JOSD2 Josephin domain containing 2 -1.53971
RGS16 regulator of G-protein signaling 16 -1.53936
UNC50 unc-50 homolog (C. elegans) -1.53071
PRDX2 peroxiredoxin 2 -1.52936
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI -1.52752
N6AMT2 N-6 adenine-specific DNA methyltransferase 2 (putative) -1.52711
CLDN11 claudin 11 -1.52601
MRPS36 mitochondrial ribosomal protein S36 -1.52256
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4 -1.52106
RSU1 Ras suppressor protein 1 -1.5197
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 -1.51936
PLP1 proteolipid protein 1 -1.51913
RAB11B RAB11B, member RAS oncogene family -1.51501
RAP1GAP RAP1 GTPase activating protein -1.51412
C16ORF13 chromosome 16 open reading frame 13 -1.51247
BCL2L2 BCL2-like 2 -1.507
EIF5 eukaryotic translation initiation factor 5 -1.50577
CD47 CD47 molecule -1.50571
FBRS fibrosin -1.49887
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -1.49848
AMMECR1L AMMECR1-like -1.49624
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa -1.49573
CHMP7 charged multivesicular body protein 7 -1.49563
OXCT1 3-oxoacid CoA transferase 1 -1.49439
TUBA1B tubulin, alpha 1b -1.4943
DCTN2 dynactin 2 (p50) -1.49094
GLTSCR2 glioma tumor suppressor candidate region gene 2 -1.48884
CLTB clathrin, light chain B -1.48836
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -1.48727
SLC25A44 solute carrier family 25, member 44 -1.48698
PTCD2 pentatricopeptide repeat domain 2 -1.48691
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 -1.48496
ACTG1 actin gamma 1 -1.48443
NPEPPS aminopeptidase puromycin sensitive -1.48403
WDR6 WD repeat domain 6 -1.48044
APCDD1 adenomatosis polyposis coli down-regulated 1 -1.47931
SH2B1 SH2B adaptor protein 1 -1.47783
MAGED2 melanoma antigen family D2 -1.47418
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) -1.46755
PADI2 peptidyl arginine deiminase, type II -1.46656
ZNF653 zinc finger protein 653 -1.46294
RPL13A ribosomal protein L13a -1.46235
CPNE1 copine I -1.4623
BRD2 bromodomain containing 2 -1.45889
PGLS 6-phosphogluconolactonase -1.4577
CSDE1 cold shock domain containing E1, RNA-binding -1.45703
HDGF hepatoma-derived growth factor -1.45322
NONO non-POU domain containing, octamer-binding -1.45156
MFSD5 major facilitator superfamily domain containing 5 -1.45047
SNX1 sorting nexin 1 -1.44872
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -1.44796
MAG myelin associated glycoprotein -1.44366
CA2 carbonic anhydrase II -1.44134
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 -1.43937
AK1 adenylate kinase 1 -1.43881
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -1.436
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 -1.43553
FAM134A family with sequence similarity 134, member A -1.43447
CECR5 cat eye syndrome chromosome region, candidate 5 -1.4321
GLG1 golgi glycoprotein 1 -1.4286
ADORA1 adenosine A1 receptor -1.42578
ILKAP integrin-linked kinase-associated serine/threonine phosphatase -1.42564
UBE2A ubiquitin-conjugating enzyme E2A -1.42561
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) -1.42486
COPS5 COP9 signalosome subunit 5 -1.4183
OSTC oligosaccharyltransferase complex subunit (non-catalytic) -1.41781
IMP3 IMP3, U3 small nucleolar ribonucleoprotein -1.41705
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -1.41662
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa -1.4141
DESI1 desumoylating isopeptidase 1 -1.4141
RIC8A RIC8 guanine nucleotide exchange factor A -1.41405
CDH5 cadherin 5, type 2 (vascular endothelium) -1.41384
GGPS1 geranylgeranyl diphosphate synthase 1 -1.41305
GHITM growth hormone inducible transmembrane protein -1.41074
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H') -1.40785
MRPL44 mitochondrial ribosomal protein L44 -1.40669
ODC1 ornithine decarboxylase 1 -1.40167
OAZ2 ornithine decarboxylase antizyme 2 -1.40006
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 -1.39026
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 -1.38916
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -1.38698
MLF2 myeloid leukemia factor 2 -1.38649
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) -1.38579
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -1.38209
HACD3 3-hydroxyacyl-CoA dehydratase 3 -1.37489
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -1.37387
GRAMD3 GRAM domain containing 3 -1.37137
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa -1.36915
RTN1 reticulon 1 -1.36694
HARS histidyl-tRNA synthetase -1.36666
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 -1.36142
HAUS6 HAUS augmin-like complex, subunit 6 -1.3612
HDAC2 histone deacetylase 2 -1.35486
TBK1 TANK-binding kinase 1 -1.35135
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide -1.35047
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -1.34553
TRPV2 transient receptor potential cation channel, subfamily V, member 2 -1.34443
SLC39A3 solute carrier family 39 (zinc transporter), member 3 -1.34159
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha -1.33608
CCDC12 coiled-coil domain containing 12 -1.33209
ABHD8 abhydrolase domain containing 8 -1.32806
CCT4 chaperonin containing TCP1, subunit 4 (delta) -1.32758
FDX1 ferredoxin 1 -1.32674
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -1.3254
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) -1.3141
CAST calpastatin -1.31402
PRAF2 PRA1 domain family, member 2 -1.31395