GW-8510-7085 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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200 genes differentially expressed following the GW-8510-7085 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
ANAPC5 anaphase promoting complex subunit 5
ARC activity-regulated cytoskeleton-associated protein
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ASRGL1 asparaginase like 1
ATG13 autophagy related 13
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
BMP1 bone morphogenetic protein 1
BRD4 bromodomain containing 4
C3 complement component 3
CA5BP1 carbonic anhydrase VB pseudogene 1
CALR calreticulin
CCDC176 coiled-coil domain containing 176
CCPG1 cell cycle progression 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLCN4 chloride channel, voltage-sensitive 4
CLSPN claspin
CLTB clathrin, light chain B
CNPY3 canopy FGF signaling regulator 3
CORT cortistatin
CS citrate synthase
CSNK1E casein kinase 1, epsilon
CUL5 cullin 5
CXCL2 chemokine (C-X-C motif) ligand 2
DNASE1L1 deoxyribonuclease I-like 1
DYNLRB1 dynein, light chain, roadblock-type 1
EGR1 early growth response 1
ERCC2 excision repair cross-complementation group 2
FADS2 fatty acid desaturase 2
FCMR Fc fragment of IgM receptor
FH fumarate hydratase
FLOT1 flotillin 1
FN3KRP fructosamine 3 kinase related protein
GABARAPL1 GABA(A) receptor-associated protein like 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GADD45B growth arrest and DNA-damage-inducible, beta
GAMT guanidinoacetate N-methyltransferase
GCAT glycine C-acetyltransferase
GLRX3 glutaredoxin 3
GOSR2 golgi SNAP receptor complex member 2
GPX4 glutathione peroxidase 4
HIST1H2AE histone cluster 1, H2ae
HIST1H2BG histone cluster 1, H2bg
HTT huntingtin
IFI30 interferon, gamma-inducible protein 30
IL6 interleukin 6
JUNB jun B proto-oncogene
KLK6 kallikrein-related peptidase 6
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KRT8P12 keratin 8 pseudogene 12
LPCAT3 lysophosphatidylcholine acyltransferase 3
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAOA monoamine oxidase A
MED16 mediator complex subunit 16
MMP1 matrix metallopeptidase 1
MOSPD3 motile sperm domain containing 3
MYLK myosin light chain kinase
NMB neuromedin B
NRSN2 neurensin 2
PCBP4 poly(rC) binding protein 4
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PDS5A PDS5 cohesin associated factor A
PI3 peptidase inhibitor 3, skin-derived
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PLXNA1 plexin A1
POMT2 protein-O-mannosyltransferase 2
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RAB40B RAB40B, member RAS oncogene family
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPL23 ribosomal protein L23
RPL37A ribosomal protein L37a
SAT1 spermidine/spermine N1-acetyltransferase 1
SDF4 stromal cell derived factor 4
SEC14L2 SEC14-like 2 (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH3BP2 SH3-domain binding protein 2
SNTA1 syntrophin, alpha 1
SSH3 slingshot protein phosphatase 3
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STOM stomatin
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TGFB3 transforming growth factor, beta 3
TKFC triokinase/FMN cyclase
TNNI3 troponin I type 3 (cardiac)
TPMT thiopurine S-methyltransferase
TRIM29 tripartite motif containing 29
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative)
UBTD1 ubiquitin domain containing 1
URI1 URI1, prefoldin-like chaperone
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
WHSC1 Wolf-Hirschhorn syndrome candidate 1
ZMAT5 zinc finger, matrin-type 5

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
ADRB2 adrenoceptor beta 2, surface
ANKRD49 ankyrin repeat domain 49
BAG3 BCL2-associated athanogene 3
BCAR3 breast cancer anti-estrogen resistance 3
BORA bora, aurora kinase A activator
BTG1 B-cell translocation gene 1, anti-proliferative
BYSL bystin-like
C14ORF169 chromosome 14 open reading frame 169
CBR3 carbonyl reductase 3
CDCA4 cell division cycle associated 4
CHD1 chromodomain helicase DNA binding protein 1
CLP1 cleavage and polyadenylation factor I subunit 1
COIL coilin
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CTCF CCCTC-binding factor (zinc finger protein)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
E2F6 E2F transcription factor 6
EFNA4 ephrin-A4
EPM2AIP1 EPM2A (laforin) interacting protein 1
ERCC6L excision repair cross-complementation group 6-like
FADD Fas (TNFRSF6)-associated via death domain
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
FBXO34 F-box protein 34
FEN1 flap structure-specific endonuclease 1
FZD2 frizzled class receptor 2
GSPT2 G1 to S phase transition 2
GTF2B general transcription factor IIB
H1F0 H1 histone family, member 0
HAS2 hyaluronan synthase 2
HIRA histone cell cycle regulator
HJURP Holliday junction recognition protein
HMGXB4 HMG box domain containing 4
HNRNPF heterogeneous nuclear ribonucleoprotein F
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IP6K2 inositol hexakisphosphate kinase 2
JMJD1C jumonji domain containing 1C
KBTBD2 kelch repeat and BTB (POZ) domain containing 2
KIFC1 kinesin family member C1
LEMD3 LEM domain containing 3
LOC100272216 uncharacterized LOC100272216
MAD2L1BP MAD2L1 binding protein
MED17 mediator complex subunit 17
MGA MGA, MAX dimerization protein
MKL2 MKL/myocardin-like 2
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
NDC80 NDC80 kinetochore complex component
NFE2L2 nuclear factor, erythroid 2-like 2
NKRF NFKB repressing factor
OXSM 3-oxoacyl-ACP synthase, mitochondrial
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLK2 polo-like kinase 2
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PTRH2 peptidyl-tRNA hydrolase 2
RANBP6 RAN binding protein 6
RBM15 RNA binding motif protein 15
RBM4B RNA binding motif protein 4B
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
RGS2 regulator of G-protein signaling 2
RIPK4 receptor-interacting serine-threonine kinase 4
RND3 Rho family GTPase 3
RNF113A ring finger protein 113A
RNF139 ring finger protein 139
RNF4 ring finger protein 4
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSBN1 round spermatid basic protein 1
SEC24B SEC24 family member B
SLC38A2 solute carrier family 38, member 2
SMG8 SMG8 nonsense mediated mRNA decay factor
SOX9 SRY (sex determining region Y)-box 9
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TBCC tubulin folding cofactor C
TBX3 T-box 3
TCEAL1 transcription elongation factor A (SII)-like 1
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TOB1 transducer of ERBB2, 1
TRIB1 tribbles pseudokinase 1
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)
TSPYL5 TSPY-like 5
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VANGL1 VANGL planar cell polarity protein 1
ZBED5 zinc finger, BED-type containing 5
ZC3H4 zinc finger CCCH-type containing 4
ZNF12 zinc finger protein 12
ZNF217 zinc finger protein 217
ZNF281 zinc finger protein 281
ZNF443 zinc finger protein 443
ZNF672 zinc finger protein 672
ZNF7 zinc finger protein 7