Frontotemporal Lobar Degeneration Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A basal ganglia disease characterized by progressive neuronal loss predominantly involving the frontal and/or temporal lobes of the brain resulting in a gradual and progressive decline in behavior or language. (Human Disease Ontology, DOID_9255)
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37 genes associated with the Frontotemporal Lobar Degeneration phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
BAG1 BCL2-associated athanogene
BDNF brain-derived neurotrophic factor
C9ORF72 chromosome 9 open reading frame 72
CHMP2B charged multivesicular body protein 2B
CHMP5 charged multivesicular body protein 5
CST3 cystatin C
FOXP2 forkhead box P2
FUS FUS RNA binding protein
GRN granulin
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
KIF24 kinesin family member 24
MAPT microtubule-associated protein tau
MOBP myelin-associated oligodendrocyte basic protein
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
OPTN optineurin
PFN1 profilin 1
PRMT1 protein arginine methyltransferase 1
PRMT3 protein arginine methyltransferase 3
PRMT8 protein arginine methyltransferase 8
PSEN1 presenilin 1
PSEN2 presenilin 2
SOD1 superoxide dismutase 1, soluble
SORT1 sortilin 1
SP4 Sp4 transcription factor
SQSTM1 sequestosome 1
TARDBP TAR DNA binding protein
TMEM106B transmembrane protein 106B
UBAP1 ubiquitin associated protein 1
UBAP2 ubiquitin associated protein 2
UBQLN2 ubiquilin 2
VEGFA vascular endothelial growth factor A