Fractures, Bone Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Breaks in bones. (Experimental Factor Ontology, EFO_0003931)
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Genes

116 genes associated with the Fractures, Bone phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ACVR2B activin A receptor, type IIB
ADAM19 ADAM metallopeptidase domain 19
ADRB3 adrenoceptor beta 3
ALOX12 arachidonate 12-lipoxygenase
ALOX15 arachidonate 15-lipoxygenase
ALPL alkaline phosphatase, liver/bone/kidney
APOE apolipoprotein E
AR androgen receptor
ARHGAP1 Rho GTPase activating protein 1
BGLAP bone gamma-carboxyglutamate (gla) protein
C17ORF53 chromosome 17 open reading frame 53
C7ORF76 chromosome 7 open reading frame 76
CCDC170 coiled-coil domain containing 170
CER1 cerberus 1, DAN family BMP antagonist
CIITA class II, major histocompatibility complex, transactivator
CLCN7 chloride channel, voltage-sensitive 7
CLEC10A C-type lectin domain family 10, member A
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COMT catechol-O-methyltransferase
CRHR1 corticotropin releasing hormone receptor 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DBP D site of albumin promoter (albumin D-box) binding protein
DHCR7 7-dehydrocholesterol reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
FABP3 fatty acid binding protein 3, muscle and heart
FAM210A family with sequence similarity 210, member A
FGFR1 fibroblast growth factor receptor 1
FMN2 formin 2
FOXL1 forkhead box L1
FTO fat mass and obesity associated
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GC group-specific component (vitamin D binding protein)
GDF5 growth differentiation factor 5
GIPR gastric inhibitory polypeptide receptor
GPATCH1 G patch domain containing 1
GREM2 gremlin 2, DAN family BMP antagonist
HDAC5 histone deacetylase 5
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IBSP integrin-binding sialoprotein
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IL15 interleukin 15
IL6 interleukin 6
INSIG2 insulin induced gene 2
ITGA1 integrin, alpha 1
JAG1 jagged 1
LACE1 lactation elevated 1
LCT lactase
LDLR low density lipoprotein receptor
LINC00326 long intergenic non-protein coding RNA 326
LRP4 low density lipoprotein receptor-related protein 4
LRP5 low density lipoprotein receptor-related protein 5
LRP6 low density lipoprotein receptor-related protein 6
LTBP3 latent transforming growth factor beta binding protein 3
MARK3 MAP/microtubule affinity-regulating kinase 3
MC4R melanocortin 4 receptor
MECP2 methyl CpG binding protein 2
MEF2C myocyte enhancer factor 2C
MEPE matrix extracellular phosphoglycoprotein
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MSTN myostatin
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MYOD1 myogenic differentiation 1
MYOG myogenin (myogenic factor 4)
NOS3 nitric oxide synthase 3 (endothelial cell)
NR1D1 nuclear receptor subfamily 1, group D, member 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PLCL1 phospholipase C-like 1
PRDM2 PR domain containing 2, with ZNF domain
PTH parathyroid hormone
PTH1R parathyroid hormone 1 receptor
PTH2R parathyroid hormone 2 receptor
PTHLH parathyroid hormone-like hormone
RSPO3 R-spondin 3
RUNX2 runt-related transcription factor 2
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SOST sclerostin
SOX4 SRY (sex determining region Y)-box 4
SOX6 SRY (sex determining region Y)-box 6
SP7 Sp7 transcription factor
SPTBN1 spectrin, beta, non-erythrocytic 1
STARD3NL STARD3 N-terminal like
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
THRA thyroid hormone receptor, alpha
TIMP2 TIMP metallopeptidase inhibitor 2
TLR4 toll-like receptor 4
TMEM135 transmembrane protein 135
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TOB1 transducer of ERBB2, 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VKORC1 vitamin K epoxide reductase complex, subunit 1
WLS wntless Wnt ligand secretion mediator
WNT16 wingless-type MMTV integration site family, member 16
ZBTB40 zinc finger and BTB domain containing 40