Fatty Liver Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description The presence of steatosis in the liver. (Human Phenotype Ontology, HP_0001397)
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Genes

339 genes associated with the Fatty Liver phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD5 abhydrolase domain containing 5
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ABR active BCR-related
ACACA acetyl-CoA carboxylase alpha
ACACB acetyl-CoA carboxylase beta
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACADVL acyl-CoA dehydrogenase, very long chain
ACAT1 acetyl-CoA acetyltransferase 1
ACAT2 acetyl-CoA acetyltransferase 2
ACKR3 atypical chemokine receptor 3
ACLY ATP citrate lyase
ACOX1 acyl-CoA oxidase 1, palmitoyl
ACSL4 acyl-CoA synthetase long-chain family member 4
ACSL5 acyl-CoA synthetase long-chain family member 5
ACTG1 actin gamma 1
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
ADK adenosine kinase
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AFP alpha-fetoprotein
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AHSG alpha-2-HS-glycoprotein
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALAS1 5'-aminolevulinate synthase 1
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALMS1 Alstrom syndrome protein 1
ANGPTL3 angiopoietin-like 3
APOA1 apolipoprotein A-I
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOC3 apolipoprotein C-III
APOC4 apolipoprotein C-IV
APOE apolipoprotein E
APOL3 apolipoprotein L, 3
APOM apolipoprotein M
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
ARG1 arginase 1
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASL argininosuccinate lyase
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BDNF brain-derived neurotrophic factor
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C4BPA complement component 4 binding protein, alpha
C5AR1 complement component 5a receptor 1
C6 complement component 6
CALD1 caldesmon 1
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAT catalase
CCL2 chemokine (C-C motif) ligand 2
CCL4 chemokine (C-C motif) ligand 4
CCL7 chemokine (C-C motif) ligand 7
CCND1 cyclin D1
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD14 CD14 molecule
CD36 CD36 molecule (thrombospondin receptor)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CETP cholesteryl ester transfer protein, plasma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHODL chondrolectin
CHUK conserved helix-loop-helix ubiquitous kinase
CLOCK clock circadian regulator
CNR1 cannabinoid receptor 1 (brain)
CNR2 cannabinoid receptor 2 (macrophage)
COL13A1 collagen, type XIII, alpha 1
COL15A1 collagen, type XV, alpha 1
COL21A1 collagen, type XXI, alpha 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL7A1 collagen, type VII, alpha 1
CPN1 carboxypeptidase N, polypeptide 1
CPT1A carnitine palmitoyltransferase 1A (liver)
CPT1B carnitine palmitoyltransferase 1B (muscle)
CPT2 carnitine palmitoyltransferase 2
CRACR2A calcium release activated channel regulator 2A
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CTHRC1 collagen triple helix repeat containing 1
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUX2 cut-like homeobox 2
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DGAT1 diacylglycerol O-acyltransferase 1
DGAT2 diacylglycerol O-acyltransferase 2
DHCR7 7-dehydrocholesterol reductase
DLD dihydrolipoamide dehydrogenase
DNAJC19 DnaJ (Hsp40) homolog, subfamily C, member 19
EDIL3 EGF-like repeats and discoidin I-like domains 3
ELOVL2 ELOVL fatty acid elongase 2
ELOVL3 ELOVL fatty acid elongase 3
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPAS1 endothelial PAS domain protein 1
ERLIN1 ER lipid raft associated 1
ESR1 estrogen receptor 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EXOC4 exocyst complex component 4
F13A1 coagulation factor XIII, A1 polypeptide
FABP1 fatty acid binding protein 1, liver
FABP2 fatty acid binding protein 2, intestinal
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS2 fatty acid desaturase 2
FAM60A family with sequence similarity 60, member A
FAS Fas cell surface death receptor
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGL1 fibrinogen-like 1
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
FLRT2 fibronectin leucine rich transmembrane protein 2
G2E3 G2/M-phase specific E3 ubiquitin protein ligase
GCK glucokinase (hexokinase 4)
GCKR glucokinase (hexokinase 4) regulator
GCLC glutamate-cysteine ligase, catalytic subunit
GDAP1 ganglioside induced differentiation associated protein 1
GGT1 gamma-glutamyltransferase 1
GH1 growth hormone 1
GLIPR1 GLI pathogenesis-related 1
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GPI glucose-6-phosphate isomerase
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GSS glutathione synthetase
GSTA1 glutathione S-transferase alpha 1
GSTA2 glutathione S-transferase alpha 2
GSTA4 glutathione S-transferase alpha 4
GSTK1 glutathione S-transferase kappa 1
GSTM1 glutathione S-transferase mu 1
GSTO1 glutathione S-transferase omega 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene)
GYG2 glycogenin 2
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HDAC1 histone deacetylase 1
HFE hemochromatosis
HK1 hexokinase 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HNF1A HNF1 homeobox A
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPK heterogeneous nuclear ribonucleoprotein K
HP haptoglobin
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12
IARS isoleucyl-tRNA synthetase
IDI1 isopentenyl-diphosphate delta isomerase 1
IFNA7 interferon, alpha 7
IFNG interferon, gamma
IFNL3 interferon, lambda 3
IFNL4 interferon, lambda 4 (gene/pseudogene)
IGFBP1 insulin-like growth factor binding protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL10 interleukin 10
IL18 interleukin 18
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
IL6 interleukin 6
IL7R interleukin 7 receptor
INSIG1 insulin induced gene 1
INSR insulin receptor
IRS1 insulin receptor substrate 1
ITGA9 integrin, alpha 9
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KLF6 Kruppel-like factor 6
LAMA1 laminin, alpha 1
LAMA4 laminin, alpha 4
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LIFR leukemia inhibitory factor receptor alpha
LIPC lipase, hepatic
LIPE lipase, hormone-sensitive
LMNA lamin A/C
LOC157273 uncharacterized LOC157273
LPAL2 lipoprotein, Lp(a)-like 2, pseudogene
LPIN1 lipin 1
LPPR4 lipid phosphate phosphatase-related protein type 4
LTF lactotransferrin
LYPLAL1 lysophospholipase-like 1
MAP2K4 mitogen-activated protein kinase kinase 4
MAPK11 mitogen-activated protein kinase 11
MAT1A methionine adenosyltransferase I, alpha
MC4R melanocortin 4 receptor
MCHR1 melanin-concentrating hormone receptor 1
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MGLL monoglyceride lipase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MLXIPL MLX interacting protein-like
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP7 matrix metallopeptidase 7
MT-CYB cytochrome b
MT1X metallothionein 1X
MT2A metallothionein 2A
MTFP1 mitochondrial fission process 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTNR1A melatonin receptor 1A
MTTP microsomal triglyceride transfer protein
MYLIP myosin regulatory light chain interacting protein
NCAN neurocan
NFIL3 nuclear factor, interleukin 3 regulated
NNMT nicotinamide N-methyltransferase
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NOX4 NADPH oxidase 4
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRF1 nuclear respiratory factor 1
NRIP1 nuclear receptor interacting protein 1
OAT ornithine aminotransferase
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PARVB parvin, beta
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PEG10 paternally expressed 10
PEMT phosphatidylethanolamine N-methyltransferase
PGM3 phosphoglucomutase 3
PHKA2 phosphorylase kinase, alpha 2 (liver)
PITPNA phosphatidylinositol transfer protein, alpha
PLIN1 perilipin 1
PLIN2 perilipin 2
PLSCR1 phospholipid scramblase 1
PLTP phospholipid transfer protein
PNPLA2 patatin-like phospholipase domain containing 2
PNPLA3 patatin-like phospholipase domain containing 3
PNRC1 proline-rich nuclear receptor coactivator 1
POU2AF1 POU class 2 associating factor 1
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2
PPP1R3B protein phosphatase 1, regulatory subunit 3B
PRSS3 protease, serine, 3
PTBP3 polypyrimidine tract binding protein 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRF protein tyrosine phosphatase, receptor type, F
PTX3 pentraxin 3, long
PYGM phosphorylase, glycogen, muscle
PZP pregnancy-zone protein
RARA retinoic acid receptor, alpha
RETN resistin
S100A8 S100 calcium binding protein A8
SAA4 serum amyloid A4, constitutive
SAMM50 SAMM50 sorting and assembly machinery component
SC5D sterol-C5-desaturase
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC4 syndecan 4
SDS serine dehydratase
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC35B4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4
SLC38A8 solute carrier family 38, member 8
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SOCS1 suppressor of cytokine signaling 1
SOCS3 suppressor of cytokine signaling 3
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SOD3 superoxide dismutase 3, extracellular
SPARCL1 SPARC-like 1 (hevin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SQLE squalene epoxidase
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
SSTR2 somatostatin receptor 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STXBP1 syntaxin binding protein 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TF transferrin
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TLR4 toll-like receptor 4
TM6SF2 transmembrane 6 superfamily member 2
TMPRSS6 transmembrane protease, serine 6
TNF tumor necrosis factor
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
UGCG UDP-glucose ceramide glucosyltransferase
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
VCAN versican
VLDLR very low density lipoprotein receptor
ZFP36 ZFP36 ring finger protein
ZGLP1 zinc finger, GATA-like protein 1
ZMPSTE24 zinc metallopeptidase STE24