Fatigue Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A subjective feeling of tiredness characterized by a lack of energy and motivation. (Human Phenotype Ontology, HP_0012378)
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Genes

69 genes associated with the Fatigue phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACE angiotensin I converting enzyme
ADA adenosine deaminase
ADK adenosine kinase
ADORA1 adenosine A1 receptor
ADORA2A adenosine A2a receptor
AHCY adenosylhomocysteinase
ANKK1 ankyrin repeat and kinase domain containing 1
APOE apolipoprotein E
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
COMT catechol-O-methyltransferase
CRP C-reactive protein, pentraxin-related
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DRD4 dopamine receptor D4
EGFR epidermal growth factor receptor
FAAH fatty acid amide hydrolase
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FLT4 fms-related tyrosine kinase 4
HFE hemochromatosis
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HRAS Harvey rat sarcoma viral oncogene homolog
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IFNG interferon, gamma
IL10 interleukin 10
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
IL6R interleukin 6 receptor
KRAS Kirsten rat sarcoma viral oncogene homolog
MAOA monoamine oxidase A
MET MET proto-oncogene, receptor tyrosine kinase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NT5C1B 5'-nucleotidase, cytosolic IB
NT5E 5'-nucleotidase, ecto (CD73)
PER3 period circadian clock 3
PKN1 protein kinase N1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC25A40 solute carrier family 25, member 40
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC29A4 solute carrier family 29 (equilibrative nucleoside transporter), member 4
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLCO1C1 solute carrier organic anion transporter family, member 1C1
TNF tumor necrosis factor
TSHR thyroid stimulating hormone receptor
TYMS thymidylate synthetase
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1