FGF signaling pathway Gene Set

Dataset PANTHER Pathways
Category structural or functional annotations
Type pathway
Description The family of fibroblast growth factors (FGF) comprises 22 ligands classified into seven phylogenetic subfamilies and three groups by mode of action: the intracellular intracrine and the extracellular paracrine or canonical and endocrine or hormone-like groups. The paracrine subfamilies signal via the fibroblast growth factor receptors (FGFR), receptor tyrosine kinases (RTK). The endocrine subfamily is FGFR-dependent but the affinity towards the receptors is low and relies on Klotho family of transmembrane proteins. The intracrine subfamily is FGFR-independent. Overall, the pathway plays important roles during embryonic and postnatal development, neuromodulation, mineral metabolism and homeostasis. Deregulation of the pathway has been associated with neoplastic and metabolic diseases. (Pathway Ontology, PW_0000328)
External Link http://www.pantherdb.org/pathway/pathDetail.do?clsAccession=P00021
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Genes

100 proteins participating in the FGF signaling pathway pathway from the PANTHER Pathways dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
FGF1 fibroblast growth factor 1 (acidic)
FGF10 fibroblast growth factor 10
FGF11 fibroblast growth factor 11
FGF12 fibroblast growth factor 12
FGF13 fibroblast growth factor 13
FGF14 fibroblast growth factor 14
FGF17 fibroblast growth factor 17
FGF18 fibroblast growth factor 18
FGF20 fibroblast growth factor 20
FGF22 fibroblast growth factor 22
FGF3 fibroblast growth factor 3
FGF4 fibroblast growth factor 4
FGF5 fibroblast growth factor 5
FGF6 fibroblast growth factor 6
FGF7 fibroblast growth factor 7
FGF8 fibroblast growth factor 8 (androgen-induced)
FGF9 fibroblast growth factor 9
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FRS2 fibroblast growth factor receptor substrate 2
GRAP GRB2-related adaptor protein
HRAS Harvey rat sarcoma viral oncogene homolog
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K6 mitogen-activated protein kinase kinase 6
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK11 mitogen-activated protein kinase 11
MAPK12 mitogen-activated protein kinase 12
MAPK13 mitogen-activated protein kinase 13
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PEBP1 phosphatidylethanolamine binding protein 1
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma
PPP2R2D protein phosphatase 2, regulatory subunit B, delta
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCG protein kinase C, gamma
PRKCH protein kinase C, eta
PRKCI protein kinase C, iota
PRKCQ protein kinase C, theta
PRKCZ protein kinase C, zeta
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RASA2 RAS p21 protein activator 2
RASA4 RAS p21 protein activator 4
RASA4B RAS p21 protein activator 4B
SFN stratifin
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY3 sprouty homolog 3 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta