EGF_PTP1B_KO vs wt_MEF (Mouse) [18515860] Gene Set

Dataset SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Gene Perturbations
Category proteomics
Type gene perturbation
Description gene perturbation identified as [gene perturbation]_[cell line] ([organism]) [[publication PMID]] (SILAC Phosphoproteomics)
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Genes

62 proteins differentially phosphorylated following the EGF_PTP1B_KO vs wt_MEF (Mouse) [18515860] gene perturbation from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Gene Perturbations dataset.

increased phosphorylation

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
ANKRD13A ankyrin repeat domain 13A
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ARHGAP12 Rho GTPase activating protein 12
ARHGAP35 Rho GTPase activating protein 35
ARHGAP5 Rho GTPase activating protein 5
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CTNND1 catenin (cadherin-associated protein), delta 1
CTTN cortactin
CYLD cylindromatosis (turban tumor syndrome)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDR2 discoidin domain receptor tyrosine kinase 2
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
EGFR epidermal growth factor receptor
EPHA4 EPH receptor A4
EPHB3 EPH receptor B3
EPN2 epsin 2
EPS15 epidermal growth factor receptor pathway substrate 15
ERBB2 erb-b2 receptor tyrosine kinase 2
FER fer (fps/fes related) tyrosine kinase
FGFR1 fibroblast growth factor receptor 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB2 GRB2-associated binding protein 2
GAREM GRB2 associated, regulator of MAPK1
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GJA1 gap junction protein, alpha 1, 43kDa
HCK HCK proto-oncogene, Src family tyrosine kinase
INPPL1 inositol polyphosphate phosphatase-like 1
ITSN2 intersectin 2
KIRREL kin of IRRE like (Drosophila)
LPP LIM domain containing preferred translocation partner in lipoma
MAPK14 mitogen-activated protein kinase 14
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PARD3 par-3 family cell polarity regulator
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PEAK1 pseudopodium-enriched atypical kinase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLCG1 phospholipase C, gamma 1
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
PXN paxillin
RIN1 Ras and Rab interactor 1
SH3PXD2A SH3 and PX domains 2A
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
ST5 suppression of tumorigenicity 5
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STAT5B signal transducer and activator of transcription 5B
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TJP1 tight junction protein 1
TNK2 tyrosine kinase, non-receptor, 2
TNS1 tensin 1
VAV3 vav 3 guanine nucleotide exchange factor
ZDHHC8 zinc finger, DHHC-type containing 8

decreased phosphorylation

Symbol Name
AXL AXL receptor tyrosine kinase
EPHB2 EPH receptor B2
EPHB4 EPH receptor B4
GAB1 GRB2-associated binding protein 1
IFITM3 interferon induced transmembrane protein 3
PDGFA platelet-derived growth factor alpha polypeptide
TNS2 tensin 2