EGFR_drugactivation_30_GDS4361 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Kinase Perturbations
Category transcriptomics
Type kinase perturbation
Description kinase perturbation identified as [kinase gene symbol]_[perturbation]_[perturbation ID]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GDS4361
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Genes

600 genes differentially expressed following the EGFR_drugactivation_30_GDS4361 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

increased expression

Symbol Name Standardized Value
KDSR 3-ketodihydrosphingosine reductase 4.7694
RACGAP1 Rac GTPase activating protein 1 3.92565
PRKDC protein kinase, DNA-activated, catalytic polypeptide 3.91411
LMBR1 limb development membrane protein 1 3.73075
FANCI Fanconi anemia, complementation group I 3.57626
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 3.52917
ZMYND8 zinc finger, MYND-type containing 8 3.45718
HJURP Holliday junction recognition protein 3.40561
PBDC1 polysaccharide biosynthesis domain containing 1 3.30512
FOXO1 forkhead box O1 3.17579
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 3.05276
PRPF4 pre-mRNA processing factor 4 2.93734
YARS tyrosyl-tRNA synthetase 2.93075
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 2.92612
WDR76 WD repeat domain 76 2.91035
SSBP1 single-stranded DNA binding protein 1, mitochondrial 2.90983
SLCO2A1 solute carrier organic anion transporter family, member 2A1 2.86801
FLNB filamin B, beta 2.86286
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2.82816
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 2.76149
LPIN1 lipin 1 2.74782
MASTL microtubule associated serine/threonine kinase-like 2.72672
ABLIM3 actin binding LIM protein family, member 3 2.71851
ITGB5 integrin, beta 5 2.69261
UNC5B unc-5 homolog B (C. elegans) 2.66776
PYGB phosphorylase, glycogen; brain 2.63778
THSD4 thrombospondin, type I, domain containing 4 2.58971
KRT6A keratin 6A, type II 2.57276
PAX8 paired box 8 2.56057
KIF2C kinesin family member 2C 2.55476
NAV2 neuron navigator 2 2.55367
HIRIP3 HIRA interacting protein 3 2.53785
UBE2D2 ubiquitin-conjugating enzyme E2D 2 2.5341
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 2.52992
TFCP2L1 transcription factor CP2-like 1 2.51585
PHGDH phosphoglycerate dehydrogenase 2.50371
SQLE squalene epoxidase 2.50254
MARS methionyl-tRNA synthetase 2.49726
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 2.48718
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 2.47988
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 2.4324
HARS histidyl-tRNA synthetase 2.39636
CDCP1 CUB domain containing protein 1 2.30664
DIAPH3 diaphanous-related formin 3 2.28716
S100A10 S100 calcium binding protein A10 2.26884
DUSP7 dual specificity phosphatase 7 2.25009
TUBB4B tubulin, beta 4B class IVb 2.22772
OPN1SW opsin 1 (cone pigments), short-wave-sensitive 2.20339
ANXA5 annexin A5 2.19888
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 2.19537
BOP1 block of proliferation 1 2.18556
RAP1GAP2 RAP1 GTPase activating protein 2 2.17919
TMEM194A transmembrane protein 194A 2.17852
IARS isoleucyl-tRNA synthetase 2.16514
UBE2L3 ubiquitin-conjugating enzyme E2L 3 2.14308
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) 2.14081
NCAPD2 non-SMC condensin I complex, subunit D2 2.13432
ITGA6 integrin, alpha 6 2.13315
ERBB2 erb-b2 receptor tyrosine kinase 2 2.13232
TGM6 transglutaminase 6 2.12889
SDC4 syndecan 4 2.12255
ANAPC5 anaphase promoting complex subunit 5 2.1044
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.10401
ZPR1 ZPR1 zinc finger 2.09829
KRT6B keratin 6B, type II 2.09029
ARF1 ADP-ribosylation factor 1 2.07766
SLC35B4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 2.07528
MSN moesin 2.05512
BCL2L1 BCL2-like 1 2.05022
GEN1 GEN1 Holliday junction 5' flap endonuclease 2.04064
SACS sacsin molecular chaperone 2.03744
FKBP4 FK506 binding protein 4, 59kDa 2.03582
CAPN2 calpain 2, (m/II) large subunit 2.0254
TICRR TOPBP1-interacting checkpoint and replication regulator 2.01059
CKS2 CDC28 protein kinase regulatory subunit 2 1.99006
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 1.98474
FAM111A family with sequence similarity 111, member A 1.98469
RNF113B ring finger protein 113B 1.9706
PLK1 polo-like kinase 1 1.96852
ODC1 ornithine decarboxylase 1 1.95887
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast) 1.93819
IPO5 importin 5 1.93712
LAMC2 laminin, gamma 2 1.9364
RRP1 ribosomal RNA processing 1 1.93292
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 1.92864
DSG3 desmoglein 3 1.9237
ZBTB10 zinc finger and BTB domain containing 10 1.91772
HIST1H1C histone cluster 1, H1c 1.91069
SND1 staphylococcal nuclease and tudor domain containing 1 1.91018
HEATR1 HEAT repeat containing 1 1.90688
NPM3 nucleophosmin/nucleoplasmin 3 1.90491
RPL36A ribosomal protein L36a 1.89066
DDIT4 DNA-damage-inducible transcript 4 1.88954
LARP1 La ribonucleoprotein domain family, member 1 1.8823
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 1.87954
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 1.878
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 1.85674
MCM8 minichromosome maintenance complex component 8 1.85512
KARS lysyl-tRNA synthetase 1.85102
LIN54 lin-54 DREAM MuvB core complex component 1.84865
PVR poliovirus receptor 1.8474
WDR74 WD repeat domain 74 1.8466
PRPF19 pre-mRNA processing factor 19 1.84514
MMGT1 membrane magnesium transporter 1 1.84126
THRAP3 thyroid hormone receptor associated protein 3 1.83852
PARP1 poly (ADP-ribose) polymerase 1 1.83751
NOL10 nucleolar protein 10 1.83371
RFC2 replication factor C (activator 1) 2, 40kDa 1.83185
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 1.83159
CIT citron rho-interacting serine/threonine kinase 1.82577
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 1.82577
CCT8 chaperonin containing TCP1, subunit 8 (theta) 1.81657
SEH1L SEH1-like (S. cerevisiae) 1.81641
RAD51 RAD51 recombinase 1.81576
RSAD2 radical S-adenosyl methionine domain containing 2 1.79649
STX2 syntaxin 2 1.78067
CLCN6 chloride channel, voltage-sensitive 6 1.78025
HSPA9 heat shock 70kDa protein 9 (mortalin) 1.76658
ETV5 ets variant 5 1.76149
DEK DEK proto-oncogene 1.74981
SMC1A structural maintenance of chromosomes 1A 1.74399
MCM2 minichromosome maintenance complex component 2 1.73845
TOP2A topoisomerase (DNA) II alpha 170kDa 1.73763
CCDC15 coiled-coil domain containing 15 1.73657
GLRX3 glutaredoxin 3 1.7334
SNRPA small nuclear ribonucleoprotein polypeptide A 1.72557
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 1.72487
SFXN1 sideroflexin 1 1.72356
TARS threonyl-tRNA synthetase 1.71331
TPM3 tropomyosin 3 1.71143
DPYSL2 dihydropyrimidinase-like 2 1.71067
CCNF cyclin F 1.71008
PRKCA protein kinase C, alpha 1.70807
TCEA1 transcription elongation factor A (SII), 1 1.70302
KIF21B kinesin family member 21B 1.7022
MED24 mediator complex subunit 24 1.70005
ILKAP integrin-linked kinase-associated serine/threonine phosphatase 1.69553
RAD51C RAD51 paralog C 1.68595
WBP11 WW domain binding protein 11 1.68352
C6ORF10 chromosome 6 open reading frame 10 1.68254
BLMH bleomycin hydrolase 1.67485
EIF3B eukaryotic translation initiation factor 3, subunit B 1.67231
OSBPL6 oxysterol binding protein-like 6 1.667
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 1.66106
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.65701
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 1.64012
NCL nucleolin 1.63731
MKI67 marker of proliferation Ki-67 1.6322
TGFBI transforming growth factor, beta-induced, 68kDa 1.62772
RUVBL2 RuvB-like AAA ATPase 2 1.62447
SART3 squamous cell carcinoma antigen recognized by T cells 3 1.62165
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor 1.62106
CKS1B CDC28 protein kinase regulatory subunit 1B 1.61948
NARS asparaginyl-tRNA synthetase 1.6176
HNRNPCL2 heterogeneous nuclear ribonucleoprotein C-like 2 1.6171
HIST1H3B histone cluster 1, H3b 1.61705
TTK TTK protein kinase 1.61321
LBR lamin B receptor 1.61027
PDCD11 programmed cell death 11 1.61003
BNC1 basonuclin 1 1.6084
PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1 1.60773
AHCY adenosylhomocysteinase 1.60747
ERLIN1 ER lipid raft associated 1 1.60683
RPS13 ribosomal protein S13 1.60665
C21ORF59 chromosome 21 open reading frame 59 1.60576
KRT18 keratin 18, type I 1.59964
CDC45 cell division cycle 45 1.59338
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 1.59318
AATF apoptosis antagonizing transcription factor 1.59303
SCNN1G sodium channel, non voltage gated 1 gamma subunit 1.59084
RPL9 ribosomal protein L9 1.58517
NSDHL NAD(P) dependent steroid dehydrogenase-like 1.57917
PON2 paraoxonase 2 1.5759
TCOF1 Treacher Collins-Franceschetti syndrome 1 1.57315
FUOM fucose mutarotase 1.57188
RFWD3 ring finger and WD repeat domain 3 1.57069
RRM1 ribonucleotide reductase M1 1.56919
PRC1 protein regulator of cytokinesis 1 1.56226
PRDX6 peroxiredoxin 6 1.56169
POLR1C polymerase (RNA) I polypeptide C, 30kDa 1.55872
ECT2 epithelial cell transforming 2 1.55846
PFKP phosphofructokinase, platelet 1.55722
CDKN3 cyclin-dependent kinase inhibitor 3 1.55228
SULF2 sulfatase 2 1.54903
TRMT6 tRNA methyltransferase 6 1.54652
SYN3 synapsin III 1.54636
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 1.54245
ADSL adenylosuccinate lyase 1.53974
KCMF1 potassium channel modulatory factor 1 1.53532
RAN RAN, member RAS oncogene family 1.52814
MYEOV myeloma overexpressed 1.52779
ANLN anillin, actin binding protein 1.52711
CCNA1 cyclin A1 1.51576
UBE2I ubiquitin-conjugating enzyme E2I 1.5115
ATAD2 ATPase family, AAA domain containing 2 1.51013
ATAD5 ATPase family, AAA domain containing 5 1.50421
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 1.50177
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 1.49773
NUP153 nucleoporin 153kDa 1.49682
TBC1D31 TBC1 domain family, member 31 1.49518
HMOX2 heme oxygenase 2 1.49427
ZCCHC7 zinc finger, CCHC domain containing 7 1.49378
MYO19 myosin XIX 1.49068
CDCA2 cell division cycle associated 2 1.48902
SLC43A3 solute carrier family 43, member 3 1.48334
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 1.4824
TACC2 transforming, acidic coiled-coil containing protein 2 1.48228
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 1.48141
EIF3A eukaryotic translation initiation factor 3, subunit A 1.47997
FAF1 Fas (TNFRSF6) associated factor 1 1.47358
CENPU centromere protein U 1.46917
MAP4 microtubule-associated protein 4 1.46831
NOP14 NOP14 nucleolar protein 1.46459
PLK4 polo-like kinase 4 1.46243
SPTBN1 spectrin, beta, non-erythrocytic 1 1.46163
DOCK9 dedicator of cytokinesis 9 1.45984
CORO1C coronin, actin binding protein, 1C 1.45969
EMC1 ER membrane protein complex subunit 1 1.45896
GOT1 glutamic-oxaloacetic transaminase 1, soluble 1.45347
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 1.45265
FNDC9 fibronectin type III domain containing 9 1.45036
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) 1.44648
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 1.44383
CSE1L CSE1 chromosome segregation 1-like (yeast) 1.43805
CFAP97 cilia and flagella associated protein 97 1.43791
PFAS phosphoribosylformylglycinamidine synthase 1.43757
TUBA1C tubulin, alpha 1c 1.4318
GARS glycyl-tRNA synthetase 1.42902
PITHD1 PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1 1.42348
KAT7 K(lysine) acetyltransferase 7 1.41829
HIP1 huntingtin interacting protein 1 1.41804
NUP35 nucleoporin 35kDa 1.41606
AREG amphiregulin 1.41513
LPL lipoprotein lipase 1.41421
UBR4 ubiquitin protein ligase E3 component n-recognin 4 1.41295
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta 1.40884
NRN1L neuritin 1-like 1.4058
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.40289
DBF4B DBF4 zinc finger B 1.40036
HPCAL1 hippocalcin-like 1 1.39808
MED14 mediator complex subunit 14 1.39721
TTLL12 tubulin tyrosine ligase-like family member 12 1.39546
C6ORF52 chromosome 6 open reading frame 52 1.39514
HELLS helicase, lymphoid-specific 1.39391
POLR1E polymerase (RNA) I polypeptide E, 53kDa 1.39351
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.39006
SNRPC small nuclear ribonucleoprotein polypeptide C 1.38757
TSC22D3 TSC22 domain family, member 3 1.38616
GNG5 guanine nucleotide binding protein (G protein), gamma 5 1.38576
TEX10 testis expressed 10 1.38497
COASY CoA synthase 1.38443
KPNB1 karyopherin (importin) beta 1 1.38391
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21 1.38063
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 1.38054
TRAPPC10 trafficking protein particle complex 10 1.3758
E2F7 E2F transcription factor 7 1.37109
NF2 neurofibromin 2 (merlin) 1.36976
NCAPG2 non-SMC condensin II complex, subunit G2 1.36233
AGO2 argonaute RISC catalytic component 2 1.3613
RAD18 RAD18 E3 ubiquitin protein ligase 1.35754
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 1.3566
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 1.35476
RPS27A ribosomal protein S27a 1.35401
YBX1 Y box binding protein 1 1.3524
PAQR8 progestin and adipoQ receptor family member VIII 1.35237
IPO7 importin 7 1.34838
NUP188 nucleoporin 188kDa 1.34744
EMP3 epithelial membrane protein 3 1.34139
CENPA centromere protein A 1.33814
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 1.33796
KHSRP KH-type splicing regulatory protein 1.33534
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 1.33351
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 1.33116
HN1 hematological and neurological expressed 1 1.32717
ELP3 elongator acetyltransferase complex subunit 3 1.32488
PSIP1 PC4 and SFRS1 interacting protein 1 1.32431
TUBB tubulin, beta class I 1.3231
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 1.32296
RNASEH2A ribonuclease H2, subunit A 1.32284
KNTC1 kinetochore associated 1 1.32109
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 1.31641
FDPS farnesyl diphosphate synthase 1.31238
SORD sorbitol dehydrogenase 1.31214
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) 1.31049
CCNA2 cyclin A2 1.31043
CASC5 cancer susceptibility candidate 5 1.30821
PES1 pescadillo ribosomal biogenesis factor 1 1.30053
ZCCHC9 zinc finger, CCHC domain containing 9 1.29931
NAP1L2 nucleosome assembly protein 1-like 2 1.29857
HSPH1 heat shock 105kDa/110kDa protein 1 1.29788
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 1.29635
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.29448
LRPPRC leucine-rich pentatricopeptide repeat containing 1.28777
SGTB small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta 1.28636
RPL39L ribosomal protein L39-like 1.28619
HACD1 3-hydroxyacyl-CoA dehydratase 1 1.28347
HIST1H3C histone cluster 1, H3c 1.28162
GMDS GDP-mannose 4,6-dehydratase 1.27739
NSMCE1 non-SMC element 1 homolog (S. cerevisiae) 1.27708
FOXM1 forkhead box M1 1.27576

decreased expression

Symbol Name Standardized Value
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 -3.9892
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 -3.95464
ADM2 adrenomedullin 2 -3.53151
INPPL1 inositol polyphosphate phosphatase-like 1 -3.45673
AKAP8L A kinase (PRKA) anchor protein 8-like -3.36707
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 -3.20421
ZNF501 zinc finger protein 501 -3.17493
PLXNB1 plexin B1 -3.16
BHLHE41 basic helix-loop-helix family, member e41 -3.11412
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -3.10451
FAAH2 fatty acid amide hydrolase 2 -2.97022
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.87177
RIPK4 receptor-interacting serine-threonine kinase 4 -2.86901
TTC19 tetratricopeptide repeat domain 19 -2.85501
BAG1 BCL2-associated athanogene -2.80824
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -2.71994
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.71294
EXOC7 exocyst complex component 7 -2.69328
C3 complement component 3 -2.66535
NUCB1 nucleobindin 1 -2.61439
LEPROTL1 leptin receptor overlapping transcript-like 1 -2.60549
PSAP prosaposin -2.54955
SASH1 SAM and SH3 domain containing 1 -2.51668
PC pyruvate carboxylase -2.48424
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 -2.48296
PXDC1 PX domain containing 1 -2.48293
TNS3 tensin 3 -2.47529
CLDN7 claudin 7 -2.47014
MARK2 MAP/microtubule affinity-regulating kinase 2 -2.44126
ADCY3 adenylate cyclase 3 -2.43787
TSPAN31 tetraspanin 31 -2.43163
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F -2.42534
C5ORF24 chromosome 5 open reading frame 24 -2.41558
GSR glutathione reductase -2.39023
LY6G5C lymphocyte antigen 6 complex, locus G5C -2.37002
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -2.36898
TIGD2 tigger transposable element derived 2 -2.35073
PBX1 pre-B-cell leukemia homeobox 1 -2.28944
PMEPA1 prostate transmembrane protein, androgen induced 1 -2.27254
CYTH2 cytohesin 2 -2.25617
SQSTM1 sequestosome 1 -2.24485
GLIPR1L2 GLI pathogenesis-related 1 like 2 -2.23046
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 -2.22943
LYPD3 LY6/PLAUR domain containing 3 -2.22283
ZFAND5 zinc finger, AN1-type domain 5 -2.22128
ERV3-1 endogenous retrovirus group 3, member 1 -2.2124
LIF leukemia inhibitory factor -2.21141
SUMF2 sulfatase modifying factor 2 -2.20527
GLCCI1 glucocorticoid induced 1 -2.19421
OTUD5 OTU deubiquitinase 5 -2.19022
CLDN1 claudin 1 -2.18555
PER2 period circadian clock 2 -2.1666
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -2.15575
LAPTM4A lysosomal protein transmembrane 4 alpha -2.1233
COL5A2 collagen, type V, alpha 2 -2.11777
PPAP2B phosphatidic acid phosphatase type 2B -2.10538
DHRS3 dehydrogenase/reductase (SDR family) member 3 -2.10527
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -2.09738
CALR calreticulin -2.09142
IER2 immediate early response 2 -2.08593
RHOQ ras homolog family member Q -2.0839
ZNFX1 zinc finger, NFX1-type containing 1 -2.07607
TCF25 transcription factor 25 (basic helix-loop-helix) -2.0526
TAS1R1 taste receptor, type 1, member 1 -2.03793
GLUL glutamate-ammonia ligase -2.0246
CCNL2 cyclin L2 -2.0245
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase -2.02137
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -2.01937
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase -2.00968
SIK1 salt-inducible kinase 1 -2.00827
IQSEC1 IQ motif and Sec7 domain 1 -2.00707
ARHGAP35 Rho GTPase activating protein 35 -1.98547
NECAP2 NECAP endocytosis associated 2 -1.97994
WBP1 WW domain binding protein 1 -1.97809
IGBP1 immunoglobulin (CD79A) binding protein 1 -1.97592
PRKCD protein kinase C, delta -1.9735
HSPA1A heat shock 70kDa protein 1A -1.9305
NFE2L2 nuclear factor, erythroid 2-like 2 -1.9265
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -1.92374
CTSD cathepsin D -1.91921
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -1.91261
CHMP3 charged multivesicular body protein 3 -1.90697
ARID5B AT rich interactive domain 5B (MRF1-like) -1.90476
TOM1 target of myb1 (chicken) -1.90069
C1ORF116 chromosome 1 open reading frame 116 -1.90004
MOAP1 modulator of apoptosis 1 -1.89684
BHLHE40 basic helix-loop-helix family, member e40 -1.89577
YPEL3 yippee-like 3 (Drosophila) -1.88594
JUNB jun B proto-oncogene -1.87837
EXT1 exostosin glycosyltransferase 1 -1.87574
LYPLA2 lysophospholipase II -1.87035
PTTG1IP pituitary tumor-transforming 1 interacting protein -1.84562
FERMT2 fermitin family member 2 -1.84542
SMOC1 SPARC related modular calcium binding 1 -1.84527
BTLA B and T lymphocyte associated -1.8419
DOCK8 dedicator of cytokinesis 8 -1.83323
UST uronyl-2-sulfotransferase -1.83012
RHOBTB3 Rho-related BTB domain containing 3 -1.82728
GDI1 GDP dissociation inhibitor 1 -1.81798
BTG1 B-cell translocation gene 1, anti-proliferative -1.81626
KCNG4 potassium channel, voltage gated modifier subfamily G, member 4 -1.81023
EIF3H eukaryotic translation initiation factor 3, subunit H -1.81022
JUN jun proto-oncogene -1.80692
CREBBP CREB binding protein -1.80331
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -1.79741
SCRN1 secernin 1 -1.79257
SNX30 sorting nexin family member 30 -1.7762
RAB11FIP1 RAB11 family interacting protein 1 (class I) -1.77414
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -1.77354
GRHL2 grainyhead-like 2 (Drosophila) -1.75594
CASP10 caspase 10, apoptosis-related cysteine peptidase -1.75401
PTPRF protein tyrosine phosphatase, receptor type, F -1.74643
NTN4 netrin 4 -1.74594
SNAI1 snail family zinc finger 1 -1.74312
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4 -1.74175
GABARAP GABA(A) receptor-associated protein -1.73991
ATP10A ATPase, class V, type 10A -1.72859
ADD1 adducin 1 (alpha) -1.72801
SCD stearoyl-CoA desaturase (delta-9-desaturase) -1.72657
ETV6 ets variant 6 -1.72565
CFAP52 cilia and flagella associated protein 52 -1.72289
PLK2 polo-like kinase 2 -1.7198
SLC39A9 solute carrier family 39, member 9 -1.7146
PLA2G16 phospholipase A2, group XVI -1.71138
SEPHS2 selenophosphate synthetase 2 -1.70845
GSTK1 glutathione S-transferase kappa 1 -1.70162
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -1.70121
ZSWIM6 zinc finger, SWIM-type containing 6 -1.69187
MSLN mesothelin -1.68912
LXN latexin -1.6824
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -1.67528
PROM2 prominin 2 -1.67003
CHGA chromogranin A -1.66512
GAS6 growth arrest-specific 6 -1.66082
L1CAM L1 cell adhesion molecule -1.65715
IGFBP3 insulin-like growth factor binding protein 3 -1.65074
HLA-G major histocompatibility complex, class I, G -1.64569
PGAP3 post-GPI attachment to proteins 3 -1.64496
IL4R interleukin 4 receptor -1.64475
ANKFY1 ankyrin repeat and FYVE domain containing 1 -1.64467
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 -1.64255
PCDHA3 protocadherin alpha 3 -1.64244
REEP5 receptor accessory protein 5 -1.64141
ITPK1 inositol-tetrakisphosphate 1-kinase -1.6387
MYD88 myeloid differentiation primary response 88 -1.63436
RIN2 Ras and Rab interactor 2 -1.62809
FZD6 frizzled class receptor 6 -1.6221
ZFP36L1 ZFP36 ring finger protein-like 1 -1.61877
NPTN neuroplastin -1.6184
ZNF740 zinc finger protein 740 -1.61541
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 -1.60844
CLSTN1 calsyntenin 1 -1.60565
FOS FBJ murine osteosarcoma viral oncogene homolog -1.58711
NRXN1 neurexin 1 -1.58665
EFNA5 ephrin-A5 -1.58007
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 -1.57071
TTC39C tetratricopeptide repeat domain 39C -1.56777
SMAD2 SMAD family member 2 -1.56293
LTBP1 latent transforming growth factor beta binding protein 1 -1.55876
MUC16 mucin 16, cell surface associated -1.55209
SH3PXD2A SH3 and PX domains 2A -1.54886
WIPI1 WD repeat domain, phosphoinositide interacting 1 -1.54675
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -1.53682
SNX19 sorting nexin 19 -1.53196
IFT122 intraflagellar transport 122 -1.53017
RHOD ras homolog family member D -1.53006
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -1.5242
SCPEP1 serine carboxypeptidase 1 -1.52214
SECISBP2 SECIS binding protein 2 -1.52163
SOD2 superoxide dismutase 2, mitochondrial -1.51563
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon -1.50643
UBXN6 UBX domain protein 6 -1.50145
IGF1R insulin-like growth factor 1 receptor -1.49917
FMO4 flavin containing monooxygenase 4 -1.49831
ESYT2 extended synaptotagmin-like protein 2 -1.4983
AGR2 anterior gradient 2 -1.48178
SLC10A7 solute carrier family 10, member 7 -1.48046
GRN granulin -1.47618
OR2M2 olfactory receptor, family 2, subfamily M, member 2 -1.47472
RHOV ras homolog family member V -1.46471
CTSA cathepsin A -1.46406
PCGF3 polycomb group ring finger 3 -1.45989
CHMP1B charged multivesicular body protein 1B -1.45823
RNF121 ring finger protein 121 -1.45814
HLA-F major histocompatibility complex, class I, F -1.45805
RALGDS ral guanine nucleotide dissociation stimulator -1.45683
ACSF2 acyl-CoA synthetase family member 2 -1.45525
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) -1.45323
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -1.44608
HEXIM1 hexamethylene bis-acetamide inducible 1 -1.44491
ST14 suppression of tumorigenicity 14 (colon carcinoma) -1.44184
EVI2A ecotropic viral integration site 2A -1.44091
ECHDC1 ethylmalonyl-CoA decarboxylase 1 -1.44069
FAM8A1 family with sequence similarity 8, member A1 -1.43759
ACSL5 acyl-CoA synthetase long-chain family member 5 -1.43438
FAM217A family with sequence similarity 217, member A -1.42979
CLPTM1 cleft lip and palate associated transmembrane protein 1 -1.42915
SLITRK6 SLIT and NTRK-like family, member 6 -1.42856
C19ORF53 chromosome 19 open reading frame 53 -1.42281
CHMP1A charged multivesicular body protein 1A -1.4221
PPP1R15A protein phosphatase 1, regulatory subunit 15A -1.42123
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -1.41701
WDR1 WD repeat domain 1 -1.41493
LGALS3 lectin, galactoside-binding, soluble, 3 -1.41343
RC3H1 ring finger and CCCH-type domains 1 -1.41315
ZNF608 zinc finger protein 608 -1.40724
NREP neuronal regeneration related protein -1.40619
RAB11FIP4 RAB11 family interacting protein 4 (class II) -1.40591
HLA-B major histocompatibility complex, class I, B -1.4058
PHYH phytanoyl-CoA 2-hydroxylase -1.40413
AMOTL2 angiomotin like 2 -1.39787
CLINT1 clathrin interactor 1 -1.39752
ZNF263 zinc finger protein 263 -1.39598
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -1.39421
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -1.3895
PLAU plasminogen activator, urokinase -1.38855
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) -1.38624
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae) -1.38621
MARCKS myristoylated alanine-rich protein kinase C substrate -1.38501
EDN1 endothelin 1 -1.38163
KDM3B lysine (K)-specific demethylase 3B -1.38084
FBXO32 F-box protein 32 -1.38021
CCDC171 coiled-coil domain containing 171 -1.37901
SEPP1 selenoprotein P, plasma, 1 -1.37858
SPTAN1 spectrin, alpha, non-erythrocytic 1 -1.37798
AZGP1 alpha-2-glycoprotein 1, zinc-binding -1.37787
PGRMC2 progesterone receptor membrane component 2 -1.36275
GBP2 guanylate binding protein 2, interferon-inducible -1.36063
SAT1 spermidine/spermine N1-acetyltransferase 1 -1.35871
FYTTD1 forty-two-three domain containing 1 -1.35571
NOL4L nucleolar protein 4-like -1.35449
MYH10 myosin, heavy chain 10, non-muscle -1.35247
SLC35E2 solute carrier family 35, member E2 -1.34969
LDLR low density lipoprotein receptor -1.34713
NEIL1 nei endonuclease VIII-like 1 (E. coli) -1.33914
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 -1.33854
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -1.33716
SLPI secretory leukocyte peptidase inhibitor -1.33404
ARSD arylsulfatase D -1.33301
JAK1 Janus kinase 1 -1.3329
MFSD1 major facilitator superfamily domain containing 1 -1.33132
ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 -1.33103
PTPRU protein tyrosine phosphatase, receptor type, U -1.3285
LRRC16A leucine rich repeat containing 16A -1.32846
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -1.32736
CCDC6 coiled-coil domain containing 6 -1.32558
RDH10 retinol dehydrogenase 10 (all-trans) -1.31889
PTK7 protein tyrosine kinase 7 (inactive) -1.3165
ACP2 acid phosphatase 2, lysosomal -1.31242
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2 -1.31211
SLC38A7 solute carrier family 38, member 7 -1.31036
KIFC3 kinesin family member C3 -1.30892
DCBLD1 discoidin, CUB and LCCL domain containing 1 -1.30839
CA13 carbonic anhydrase XIII -1.3076
MOCOS molybdenum cofactor sulfurase -1.30474
GM2A GM2 ganglioside activator -1.30311
HLA-A major histocompatibility complex, class I, A -1.30123
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 -1.29771
CHP1 calcineurin-like EF-hand protein 1 -1.29696
ABHD4 abhydrolase domain containing 4 -1.29633
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 -1.29616
GOLPH3 golgi phosphoprotein 3 (coat-protein) -1.29526
PSPC1 paraspeckle component 1 -1.28857
NCOA1 nuclear receptor coactivator 1 -1.28855
TP63 tumor protein p63 -1.28566
CTGF connective tissue growth factor -1.28457
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -1.28406
PTPRM protein tyrosine phosphatase, receptor type, M -1.28378
PKI55 DKFZp434H1419 -1.28356
MRFAP1 Morf4 family associated protein 1 -1.27871
WFDC2 WAP four-disulfide core domain 2 -1.27854
MMP7 matrix metallopeptidase 7 -1.27604
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) -1.27514
OSBPL2 oxysterol binding protein-like 2 -1.27442
PRICKLE1 prickle homolog 1 (Drosophila) -1.27279
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -1.27139
UBB ubiquitin B -1.26917
CRIP2 cysteine-rich protein 2 -1.26851
DHPS deoxyhypusine synthase -1.2674
PPP1R3B protein phosphatase 1, regulatory subunit 3B -1.26585
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin -1.26564
BICC1 BicC family RNA binding protein 1 -1.26435
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 -1.26376
ACO1 aconitase 1, soluble -1.26352
MTFR1L mitochondrial fission regulator 1-like -1.26223
CYBRD1 cytochrome b reductase 1 -1.25815
USP46 ubiquitin specific peptidase 46 -1.25697
ACADVL acyl-CoA dehydrogenase, very long chain -1.25559
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -1.25239
LATS2 large tumor suppressor kinase 2 -1.25228
EPHA2 EPH receptor A2 -1.24994
ACTB actin, beta -1.24915
LAMP1 lysosomal-associated membrane protein 1 -1.24158
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 -1.23737
COL12A1 collagen, type XII, alpha 1 -1.23708
MED13L mediator complex subunit 13-like -1.23432
FZD7 frizzled class receptor 7 -1.23273
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 -1.23215
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 -1.23077
SAR1A secretion associated, Ras related GTPase 1A -1.22943