EGFR_drugactivation_19_GDS2146 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Kinase Perturbations
Category transcriptomics
Type kinase perturbation
Description kinase perturbation identified as [kinase gene symbol]_[perturbation]_[perturbation ID]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GDS2146
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Genes

600 genes differentially expressed following the EGFR_drugactivation_19_GDS2146 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

increased expression

Symbol Name Standardized Value
SAT1 spermidine/spermine N1-acetyltransferase 1 6.67509
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 3.49238
ELAC2 elaC ribonuclease Z 2 3.09438
PEX11B peroxisomal biogenesis factor 11 beta 2.74013
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) 2.39715
FAM188A family with sequence similarity 188, member A 2.3766
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.22948
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 2.22483
GYPC glycophorin C (Gerbich blood group) 2.21068
MYOF myoferlin 2.19914
PXN paxillin 2.08119
LRRC8B leucine rich repeat containing 8 family, member B 2.02683
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 2.00513
FKBP5 FK506 binding protein 5 1.90808
ERRFI1 ERBB receptor feedback inhibitor 1 1.85764
AKAP12 A kinase (PRKA) anchor protein 12 1.83667
PVR poliovirus receptor 1.8316
BCAR3 breast cancer anti-estrogen resistance 3 1.80231
LAMC1 laminin, gamma 1 (formerly LAMB2) 1.75714
RHOQ ras homolog family member Q 1.75417
SMIM3 small integral membrane protein 3 1.72775
KCTD5 potassium channel tetramerization domain containing 5 1.7136
CDK17 cyclin-dependent kinase 17 1.68841
ENPEP glutamyl aminopeptidase (aminopeptidase A) 1.66668
KLF13 Kruppel-like factor 13 1.64281
TGIF1 TGFB-induced factor homeobox 1 1.64217
SYMPK symplekin 1.61236
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 1.61115
CIRH1A cirrhosis, autosomal recessive 1A (cirhin) 1.58189
MAP2K3 mitogen-activated protein kinase kinase 3 1.52811
IL6ST interleukin 6 signal transducer 1.52088
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 1.5123
PRPS1 phosphoribosyl pyrophosphate synthetase 1 1.49376
FBL fibrillarin 1.4882
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 1.47365
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.42799
TRMT6 tRNA methyltransferase 6 1.4197
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 1.40796
PDPN podoplanin 1.40237
BYSL bystin-like 1.39104
CCNH cyclin H 1.38046
COQ10B coenzyme Q10 homolog B (S. cerevisiae) 1.37742
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 1.37622
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 1.36704
RNF138 ring finger protein 138, E3 ubiquitin protein ligase 1.3401
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 1.33848
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 1.31614
MLX MLX, MAX dimerization protein 1.31103
METRNL meteorin, glial cell differentiation regulator-like 1.29146
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 1.28635
CLIC1 chloride intracellular channel 1 1.27004
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) 1.26802
CD44 CD44 molecule (Indian blood group) 1.25899
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 1.25556
WNT2 wingless-type MMTV integration site family member 2 1.25526
RASAL2 RAS protein activator like 2 1.24454
SRFBP1 serum response factor binding protein 1 1.22877
SLC30A7 solute carrier family 30 (zinc transporter), member 7 1.22782
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.22533
KIFC3 kinesin family member C3 1.20873
STARD13 StAR-related lipid transfer (START) domain containing 13 1.20137
TMX1 thioredoxin-related transmembrane protein 1 1.20016
ACSL4 acyl-CoA synthetase long-chain family member 4 1.18532
MTAP methylthioadenosine phosphorylase 1.18356
BST1 bone marrow stromal cell antigen 1 1.18038
RNF219 ring finger protein 219 1.1623
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 1.13718
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 1.13203
STRAP serine/threonine kinase receptor associated protein 1.12814
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 1.10386
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 1.09975
PFKP phosphofructokinase, platelet 1.09408
CTTNBP2NL CTTNBP2 N-terminal like 1.09401
MCFD2 multiple coagulation factor deficiency 2 1.09163
PNPT1 polyribonucleotide nucleotidyltransferase 1 1.08353
RPF2 ribosome production factor 2 homolog (S. cerevisiae) 1.07408
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) 1.07176
TNC tenascin C 1.07099
AXL AXL receptor tyrosine kinase 1.07086
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.05577
PFDN4 prefoldin subunit 4 1.05242
MCL1 myeloid cell leukemia 1 1.04761
RABEP1 rabaptin, RAB GTPase binding effector protein 1 1.04634
ETF1 eukaryotic translation termination factor 1 1.03363
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 1.03293
RPS24 ribosomal protein S24 1.03196
MAP1B microtubule-associated protein 1B 1.02758
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 1.02727
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 1.02705
TMA16 translation machinery associated 16 homolog (S. cerevisiae) 1.02681
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 1.02157
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 1.01227
NR2C2AP nuclear receptor 2C2-associated protein 1.01084
POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa 1.00222
CFLAR CASP8 and FADD-like apoptosis regulator 0.991394
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 0.98613
TJP2 tight junction protein 2 0.974796
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 0.961647
NIP7 NIP7, nucleolar pre-rRNA processing protein 0.956444
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 0.949395
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 0.925221
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.921746
ERCC1 excision repair cross-complementation group 1 0.905098
FHL3 four and a half LIM domains 3 0.901646
TTLL12 tubulin tyrosine ligase-like family member 12 0.891678
MRPS18B mitochondrial ribosomal protein S18B 0.889743
SNRPF small nuclear ribonucleoprotein polypeptide F 0.887748
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 0.885458
PCGF3 polycomb group ring finger 3 0.885055
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 0.884177
LITAF lipopolysaccharide-induced TNF factor 0.881418
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.871669
PRR5 proline rich 5 (renal) 0.868901
EIF3D eukaryotic translation initiation factor 3, subunit D 0.865228
PGAM1 phosphoglycerate mutase 1 (brain) 0.864955
NAMPT nicotinamide phosphoribosyltransferase 0.863502
UBE4B ubiquitination factor E4B 0.859026
CERS2 ceramide synthase 2 0.858148
MAN1C1 mannosidase, alpha, class 1C, member 1 0.856362
LGALS3 lectin, galactoside-binding, soluble, 3 0.853033
BAIAP2 BAI1-associated protein 2 0.845666
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.845167
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) 0.84514
JUN jun proto-oncogene 0.843972
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.841193
EVA1C eva-1 homolog C (C. elegans) 0.840634
AREG amphiregulin 0.840007
SGK1 serum/glucocorticoid regulated kinase 1 0.8381
ADIPOR2 adiponectin receptor 2 0.834701
CSK c-src tyrosine kinase 0.831615
HSPH1 heat shock 105kDa/110kDa protein 1 0.823148
SLC39A13 solute carrier family 39 (zinc transporter), member 13 0.821785
DOK5 docking protein 5 0.821231
TGM1 transglutaminase 1 0.821132
JAGN1 jagunal homolog 1 (Drosophila) 0.819561
MITF microphthalmia-associated transcription factor 0.816873
MEDAG mesenteric estrogen-dependent adipogenesis 0.810158
WBSCR22 Williams Beuren syndrome chromosome region 22 0.799886
UGDH UDP-glucose 6-dehydrogenase 0.796256
SPAG9 sperm associated antigen 9 0.795551
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa 0.794159
DUSP14 dual specificity phosphatase 14 0.792435
HIGD1A HIG1 hypoxia inducible domain family, member 1A 0.788391
COPS5 COP9 signalosome subunit 5 0.787296
SENP5 SUMO1/sentrin specific peptidase 5 0.785672
PCDH18 protocadherin 18 0.772876
SLTM SAFB-like, transcription modulator 0.772517
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.766802
MTMR10 myotubularin related protein 10 0.763742
FTSJ3 FtsJ homolog 3 (E. coli) 0.762942
USPL1 ubiquitin specific peptidase like 1 0.759193
SERTAD1 SERTA domain containing 1 0.758146
WDR77 WD repeat domain 77 0.75468
SCHIP1 schwannomin interacting protein 1 0.754502
ESM1 endothelial cell-specific molecule 1 0.753177
ELMOD1 ELMO/CED-12 domain containing 1 0.750295
ARL4C ADP-ribosylation factor-like 4C 0.74732
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.745601
HIP1 huntingtin interacting protein 1 0.742928
ZNF639 zinc finger protein 639 0.734634
NMD3 NMD3 ribosome export adaptor 0.734383
IFRD1 interferon-related developmental regulator 1 0.729005
TXNRD1 thioredoxin reductase 1 0.726701
EIF1AD eukaryotic translation initiation factor 1A domain containing 0.726474
RALB v-ral simian leukemia viral oncogene homolog B 0.725501
DNMBP dynamin binding protein 0.725419
NOP56 NOP56 ribonucleoprotein 0.722691
VCL vinculin 0.719914
GSPT1 G1 to S phase transition 1 0.717707
SLC39A6 solute carrier family 39 (zinc transporter), member 6 0.717056
MAPK6 mitogen-activated protein kinase 6 0.714075
NFE2L2 nuclear factor, erythroid 2-like 2 0.709394
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1 0.708059
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.707999
SCAF11 SR-related CTD-associated factor 11 0.707681
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 0.700091
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.696765
FEM1C fem-1 homolog c (C. elegans) 0.695386
EPN2 epsin 2 0.695219
SOAT1 sterol O-acyltransferase 1 0.694216
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.692932
NUP62 nucleoporin 62kDa 0.692439
ELOVL1 ELOVL fatty acid elongase 1 0.692043
PRMT1 protein arginine methyltransferase 1 0.691256
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.690096
GLRX glutaredoxin (thioltransferase) 0.686213
GFM1 G elongation factor, mitochondrial 1 0.684555
FDPS farnesyl diphosphate synthase 0.682333
LDHA lactate dehydrogenase A 0.680761
AMD1 adenosylmethionine decarboxylase 1 0.680491
SOX11 SRY (sex determining region Y)-box 11 0.680298
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.680207
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.678157
THOC6 THO complex 6 0.675691
ENO1 enolase 1, (alpha) 0.675544
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.674476
ARF3 ADP-ribosylation factor 3 0.673026
EIF3G eukaryotic translation initiation factor 3, subunit G 0.671725
GPATCH4 G patch domain containing 4 0.670623
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) 0.668816
AGPAT6 1-acylglycerol-3-phosphate O-acyltransferase 6 0.668794
WDR43 WD repeat domain 43 0.667825
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.667667
TRIB2 tribbles pseudokinase 2 0.665199
TTC9 tetratricopeptide repeat domain 9 0.664479
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast) 0.663881
RRP7A ribosomal RNA processing 7 homolog A (S. cerevisiae) 0.66385
SOCS5 suppressor of cytokine signaling 5 0.663293
GXYLT1 glucoside xylosyltransferase 1 0.661336
ODC1 ornithine decarboxylase 1 0.659847
KRAS Kirsten rat sarcoma viral oncogene homolog 0.656221
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.65292
RFK riboflavin kinase 0.651566
RIPK3 receptor-interacting serine-threonine kinase 3 0.650288
SCAF4 SR-related CTD-associated factor 4 0.64839
PES1 pescadillo ribosomal biogenesis factor 1 0.645509
FAM104A family with sequence similarity 104, member A 0.644731
ETV3 ets variant 3 0.643272
EBNA1BP2 EBNA1 binding protein 2 0.642934
CSPG4 chondroitin sulfate proteoglycan 4 0.642035
CCT8 chaperonin containing TCP1, subunit 8 (theta) 0.638554
FJX1 four jointed box 1 (Drosophila) 0.636713
MRPL17 mitochondrial ribosomal protein L17 0.632365
CCDC137 coiled-coil domain containing 137 0.627753
TLK2 tousled-like kinase 2 0.626015
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 0.623936
METTL16 methyltransferase like 16 0.621891
ADGRG1 adhesion G protein-coupled receptor G1 0.620452
CXCL16 chemokine (C-X-C motif) ligand 16 0.619847
MYO1E myosin IE 0.616347
EIF4E2 eukaryotic translation initiation factor 4E family member 2 0.613976
KLF6 Kruppel-like factor 6 0.613605
BHLHE40 basic helix-loop-helix family, member e40 0.610207
FAM133B family with sequence similarity 133, member B 0.609454
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21 0.609363
STAMBPL1 STAM binding protein-like 1 0.60852
SRSF1 serine/arginine-rich splicing factor 1 0.607394
PAMR1 peptidase domain containing associated with muscle regeneration 1 0.606423
JARID2 jumonji, AT rich interactive domain 2 0.603285
BZW2 basic leucine zipper and W2 domains 2 0.60273
ENOPH1 enolase-phosphatase 1 0.600253
MRPL19 mitochondrial ribosomal protein L19 0.599704
RIPK2 receptor-interacting serine-threonine kinase 2 0.59844
NAV2 neuron navigator 2 0.598152
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.597937
UGCG UDP-glucose ceramide glucosyltransferase 0.597398
SLC31A2 solute carrier family 31 (copper transporter), member 2 0.5964
PROCR protein C receptor, endothelial 0.594041
FST follistatin 0.592445
HBEGF heparin-binding EGF-like growth factor 0.591724
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) 0.58946
NOP9 NOP9 nucleolar protein 0.586418
USP36 ubiquitin specific peptidase 36 0.583829
TRIP12 thyroid hormone receptor interactor 12 0.583481
CUL2 cullin 2 0.580611
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 0.57882
TMEM185B transmembrane protein 185B 0.577937
DLG1 discs, large homolog 1 (Drosophila) 0.577714
SHMT1 serine hydroxymethyltransferase 1 (soluble) 0.574182
ACSL1 acyl-CoA synthetase long-chain family member 1 0.573525
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 0.573453
MPHOSPH6 M-phase phosphoprotein 6 0.572914
EMC6 ER membrane protein complex subunit 6 0.571594
HK2 hexokinase 2 0.569218
SPIRE1 spire-type actin nucleation factor 1 0.567201
NUP205 nucleoporin 205kDa 0.564609
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.562495
FLRT3 fibronectin leucine rich transmembrane protein 3 0.561866
ZNHIT2 zinc finger, HIT-type containing 2 0.561714
DNAAF5 dynein, axonemal, assembly factor 5 0.561513
EXOSC2 exosome component 2 0.561501
IER3 immediate early response 3 0.561127
SLBP stem-loop binding protein 0.559197
SDC1 syndecan 1 0.559111
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae) 0.558822
VDAC2 voltage-dependent anion channel 2 0.558433
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.555348
CIB1 calcium and integrin binding 1 (calmyrin) 0.554647
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.551858
TOP1 topoisomerase (DNA) I 0.547774
MICU3 mitochondrial calcium uptake family, member 3 0.547044
ANKRD49 ankyrin repeat domain 49 0.546426
MRPS2 mitochondrial ribosomal protein S2 0.54544
IQGAP1 IQ motif containing GTPase activating protein 1 0.544474
ARF6 ADP-ribosylation factor 6 0.54338
ARG1 arginase 1 0.542163
GABPB1 GA binding protein transcription factor, beta subunit 1 0.541877
RBM17 RNA binding motif protein 17 0.541836
ACOT9 acyl-CoA thioesterase 9 0.539599
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 0.53915
LTV1 LTV1 ribosome biogenesis factor 0.53872
OGFRL1 opioid growth factor receptor-like 1 0.538386
THOC1 THO complex 1 0.538381
E2F5 E2F transcription factor 5, p130-binding 0.537121
MYBBP1A MYB binding protein (P160) 1a 0.535697
KPNB1 karyopherin (importin) beta 1 0.535014
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.533158
SYS1 Sys1 golgi trafficking protein 0.531217
ANKRD28 ankyrin repeat domain 28 0.530236
RUVBL1 RuvB-like AAA ATPase 1 0.52582

decreased expression

Symbol Name Standardized Value
ZFAND6 zinc finger, AN1-type domain 6 -2.84085
XDH xanthine dehydrogenase -2.43906
CIR1 corepressor interacting with RBPJ, 1 -2.41367
CEP19 centrosomal protein 19kDa -2.40369
ETFDH electron-transferring-flavoprotein dehydrogenase -2.37993
BOC BOC cell adhesion associated, oncogene regulated -2.21145
FAM117B family with sequence similarity 117, member B -2.07107
SLMAP sarcolemma associated protein -2.01395
MRPS33 mitochondrial ribosomal protein S33 -1.86858
FILIP1L filamin A interacting protein 1-like -1.85539
DENND4A DENN/MADD domain containing 4A -1.80625
RILPL2 Rab interacting lysosomal protein-like 2 -1.80004
ZNF579 zinc finger protein 579 -1.77427
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -1.7157
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -1.68461
ZRANB3 zinc finger, RAN-binding domain containing 3 -1.67722
GRHPR glyoxylate reductase/hydroxypyruvate reductase -1.67667
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -1.61681
LMO4 LIM domain only 4 -1.59674
NGLY1 N-glycanase 1 -1.58479
ZFYVE21 zinc finger, FYVE domain containing 21 -1.48777
TBCCD1 TBCC domain containing 1 -1.48646
COMMD9 COMM domain containing 9 -1.46858
FAM63A family with sequence similarity 63, member A -1.45648
MXRA8 matrix-remodelling associated 8 -1.43194
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B -1.41297
XRCC6BP1 XRCC6 binding protein 1 -1.4074
ELMO2 engulfment and cell motility 2 -1.40735
COASY CoA synthase -1.37855
PHF8 PHD finger protein 8 -1.37012
RAB11FIP1 RAB11 family interacting protein 1 (class I) -1.34726
ACOX3 acyl-CoA oxidase 3, pristanoyl -1.33842
H1F0 H1 histone family, member 0 -1.33565
TMX2 thioredoxin-related transmembrane protein 2 -1.32394
TSPAN3 tetraspanin 3 -1.31995
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) -1.31483
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -1.30777
TMUB2 transmembrane and ubiquitin-like domain containing 2 -1.29657
RNF26 ring finger protein 26 -1.28773
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -1.25863
PARVA parvin, alpha -1.25348
FGFR3 fibroblast growth factor receptor 3 -1.25154
FZD8 frizzled class receptor 8 -1.23958
NONO non-POU domain containing, octamer-binding -1.21253
TMEM136 transmembrane protein 136 -1.20596
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -1.20277
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 -1.20127
EIF4B eukaryotic translation initiation factor 4B -1.18446
GLT8D1 glycosyltransferase 8 domain containing 1 -1.1834
EVI5 ecotropic viral integration site 5 -1.17701
LMCD1 LIM and cysteine-rich domains 1 -1.17614
GGCX gamma-glutamyl carboxylase -1.17202
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) -1.15231
IVD isovaleryl-CoA dehydrogenase -1.14804
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) -1.14404
EXOC3 exocyst complex component 3 -1.13318
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -1.12471
TNIP1 TNFAIP3 interacting protein 1 -1.12289
RBM39 RNA binding motif protein 39 -1.11945
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -1.11274
VPS26B vacuolar protein sorting 26 homolog B (S. pombe) -1.10752
VCAM1 vascular cell adhesion molecule 1 -1.10499
RAB12 RAB12, member RAS oncogene family -1.09458
BNC2 basonuclin 2 -1.09135
TXNIP thioredoxin interacting protein -1.08934
FCHSD2 FCH and double SH3 domains 2 -1.0842
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -1.08156
VKORC1 vitamin K epoxide reductase complex, subunit 1 -1.06788
SH3D19 SH3 domain containing 19 -1.03957
ANAPC2 anaphase promoting complex subunit 2 -1.03716
DGCR2 DiGeorge syndrome critical region gene 2 -1.02489
SKAP2 src kinase associated phosphoprotein 2 -1.02482
HDDC3 HD domain containing 3 -1.01918
PCNX pecanex homolog (Drosophila) -1.0174
CCDC90B coiled-coil domain containing 90B -1.00919
MAGED1 melanoma antigen family D1 -1.0011
CDO1 cysteine dioxygenase type 1 -1.00107
COG6 component of oligomeric golgi complex 6 -0.998214
DOLK dolichol kinase -0.997565
PON2 paraoxonase 2 -0.997057
SLC22A18 solute carrier family 22, member 18 -0.99054
NTPCR nucleoside-triphosphatase, cancer-related -0.989195
HEXB hexosaminidase B (beta polypeptide) -0.986764
FBXL8 F-box and leucine-rich repeat protein 8 -0.982129
RBL2 retinoblastoma-like 2 -0.981522
INPP5K inositol polyphosphate-5-phosphatase K -0.980414
MBD5 methyl-CpG binding domain protein 5 -0.977256
TRIM2 tripartite motif containing 2 -0.969903
CXCL12 chemokine (C-X-C motif) ligand 12 -0.962407
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 -0.960539
USP39 ubiquitin specific peptidase 39 -0.959371
ANGPT2 angiopoietin 2 -0.956811
SLC35A5 solute carrier family 35, member A5 -0.956631
NEK7 NIMA-related kinase 7 -0.952365
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 -0.946472
RAD21 RAD21 homolog (S. pombe) -0.941773
BMP4 bone morphogenetic protein 4 -0.937673
ZNF266 zinc finger protein 266 -0.935668
SELENBP1 selenium binding protein 1 -0.935122
SRI sorcin -0.92893
GLTSCR2 glioma tumor suppressor candidate region gene 2 -0.927538
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 -0.924501
CCNG2 cyclin G2 -0.921812
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4 -0.917411
TCF4 transcription factor 4 -0.909144
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 -0.90733
SRPX2 sushi-repeat containing protein, X-linked 2 -0.902886
SUMF2 sulfatase modifying factor 2 -0.900781
MKRN2 makorin ring finger protein 2 -0.89611
ISCU iron-sulfur cluster assembly enzyme -0.893612
JKAMP JNK1/MAPK8-associated membrane protein -0.890015
TTC28 tetratricopeptide repeat domain 28 -0.889388
CCNG1 cyclin G1 -0.883182
CEP120 centrosomal protein 120kDa -0.882833
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.880688
ULK1 unc-51 like autophagy activating kinase 1 -0.880468
RAB30 RAB30, member RAS oncogene family -0.879412
CNTROB centrobin, centrosomal BRCA2 interacting protein -0.87338
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.873359
TECR trans-2,3-enoyl-CoA reductase -0.867966
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.860232
ESD esterase D -0.859248
SERINC3 serine incorporator 3 -0.855259
EDEM2 ER degradation enhancer, mannosidase alpha-like 2 -0.84946
LRRC57 leucine rich repeat containing 57 -0.849112
POGLUT1 protein O-glucosyltransferase 1 -0.847591
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.830944
EHBP1 EH domain binding protein 1 -0.828454
KIAA0430 KIAA0430 -0.825885
TTC13 tetratricopeptide repeat domain 13 -0.825607
COPG1 coatomer protein complex, subunit gamma 1 -0.82353
DPYSL2 dihydropyrimidinase-like 2 -0.820855
RAB2B RAB2B, member RAS oncogene family -0.816456
ADD3 adducin 3 (gamma) -0.815836
EDN1 endothelin 1 -0.815684
PRPS2 phosphoribosyl pyrophosphate synthetase 2 -0.808932
MXI1 MAX interactor 1, dimerization protein -0.806922
LPL lipoprotein lipase -0.805466
AGTR1 angiotensin II receptor, type 1 -0.804065
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 -0.80406
FAM198B family with sequence similarity 198, member B -0.801887
CD47 CD47 molecule -0.798398
SYNJ2BP synaptojanin 2 binding protein -0.797477
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 -0.796829
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.795243
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) -0.792851
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -0.791331
HES6 hes family bHLH transcription factor 6 -0.790871
ACAD11 acyl-CoA dehydrogenase family, member 11 -0.790256
TCEAL1 transcription elongation factor A (SII)-like 1 -0.789881
WWC2 WW and C2 domain containing 2 -0.789265
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.787783
RRM1 ribonucleotide reductase M1 -0.787242
FBXL4 F-box and leucine-rich repeat protein 4 -0.783814
DIRC2 disrupted in renal carcinoma 2 -0.781422
CDK19 cyclin-dependent kinase 19 -0.781034
SMAD1 SMAD family member 1 -0.777017
GADD45B growth arrest and DNA-damage-inducible, beta -0.773382
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.770661
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) -0.766665
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase -0.765336
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D -0.765271
INO80B INO80 complex subunit B -0.763978
RMI1 RecQ mediated genome instability 1 -0.760058
HIGD2A HIG1 hypoxia inducible domain family, member 2A -0.758438
SAMD14 sterile alpha motif domain containing 14 -0.757281
POLE4 polymerase (DNA-directed), epsilon 4, accessory subunit -0.754664
CNPY2 canopy FGF signaling regulator 2 -0.751845
PPOX protoporphyrinogen oxidase -0.751416
LEPROT leptin receptor overlapping transcript -0.750919
EBF1 early B-cell factor 1 -0.742509
NRP1 neuropilin 1 -0.740304
LATS2 large tumor suppressor kinase 2 -0.738517
TMEM45A transmembrane protein 45A -0.735935
MSL3 male-specific lethal 3 homolog (Drosophila) -0.734681
SCARA5 scavenger receptor class A, member 5 -0.734574
RNF14 ring finger protein 14 -0.734389
SMIM20 small integral membrane protein 20 -0.733167
VLDLR very low density lipoprotein receptor -0.732329
XPO1 exportin 1 -0.72678
APOO apolipoprotein O -0.726773
HMGB2 high mobility group box 2 -0.726572
RAB13 RAB13, member RAS oncogene family -0.723743
IFT172 intraflagellar transport 172 -0.720268
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 -0.715318
DERA deoxyribose-phosphate aldolase (putative) -0.71457
FAM3A family with sequence similarity 3, member A -0.714215
TPP1 tripeptidyl peptidase I -0.710535
CLIC3 chloride intracellular channel 3 -0.710346
TSPAN6 tetraspanin 6 -0.709834
LAPTM4B lysosomal protein transmembrane 4 beta -0.709237
SNX1 sorting nexin 1 -0.708579
KIF22 kinesin family member 22 -0.707776
METTL20 methyltransferase like 20 -0.704989
SERTAD4 SERTA domain containing 4 -0.704213
PI4KB phosphatidylinositol 4-kinase, catalytic, beta -0.70279
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.701741
VPS25 vacuolar protein sorting 25 homolog (S. cerevisiae) -0.699574
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 -0.698204
NCAPH2 non-SMC condensin II complex, subunit H2 -0.697712
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) -0.695708
PHYH phytanoyl-CoA 2-hydroxylase -0.69535
CYB561D2 cytochrome b561 family, member D2 -0.693772
HP1BP3 heterochromatin protein 1, binding protein 3 -0.692796
KLHL24 kelch-like family member 24 -0.692691
OXR1 oxidation resistance 1 -0.689245
NTNG1 netrin G1 -0.688597
CMTM3 CKLF-like MARVEL transmembrane domain containing 3 -0.688562
LONP2 lon peptidase 2, peroxisomal -0.684931
TNRC6C trinucleotide repeat containing 6C -0.682527
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 -0.680676
WDFY3 WD repeat and FYVE domain containing 3 -0.677464
PMVK phosphomevalonate kinase -0.675643
TSPYL4 TSPY-like 4 -0.673821
KDELC2 KDEL (Lys-Asp-Glu-Leu) containing 2 -0.673028
CCS copper chaperone for superoxide dismutase -0.672473
RCN3 reticulocalbin 3, EF-hand calcium binding domain -0.67195
MKRN1 makorin ring finger protein 1 -0.670423
PARP9 poly (ADP-ribose) polymerase family, member 9 -0.664184
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.660183
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) -0.657397
NCAPD3 non-SMC condensin II complex, subunit D3 -0.656805
COG1 component of oligomeric golgi complex 1 -0.656316
MFSD1 major facilitator superfamily domain containing 1 -0.655967
TC2N tandem C2 domains, nuclear -0.655696
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -0.654705
PAWR PRKC, apoptosis, WT1, regulator -0.654037
AGA aspartylglucosaminidase -0.654002
NICN1 nicolin 1 -0.653097
UBLCP1 ubiquitin-like domain containing CTD phosphatase 1 -0.650022
PXMP4 peroxisomal membrane protein 4, 24kDa -0.648476
PLD2 phospholipase D2 -0.648339
TMEM88 transmembrane protein 88 -0.648264
IRF9 interferon regulatory factor 9 -0.647683
MOB2 MOB kinase activator 2 -0.647352
PDLIM2 PDZ and LIM domain 2 (mystique) -0.646386
TTC23 tetratricopeptide repeat domain 23 -0.646219
GRB14 growth factor receptor-bound protein 14 -0.64609
ECH1 enoyl CoA hydratase 1, peroxisomal -0.645584
MAT2B methionine adenosyltransferase II, beta -0.644974
PROSER1 proline and serine rich 1 -0.643766
TNRC6A trinucleotide repeat containing 6A -0.640032
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.637192
RB1CC1 RB1-inducible coiled-coil 1 -0.634585
LXN latexin -0.634093
GALK2 galactokinase 2 -0.63407
TM9SF2 transmembrane 9 superfamily member 2 -0.631483
GAK cyclin G associated kinase -0.630125
FAHD2B fumarylacetoacetate hydrolase domain containing 2B -0.630039
CYTL1 cytokine-like 1 -0.628373
GEMIN2 gem (nuclear organelle) associated protein 2 -0.628353
TM9SF4 transmembrane 9 superfamily protein member 4 -0.627689
TXNDC15 thioredoxin domain containing 15 -0.626912
RNPC3 RNA-binding region (RNP1, RRM) containing 3 -0.626707
L3HYPDH L-3-hydroxyproline dehydratase (trans-) -0.626447
ALCAM activated leukocyte cell adhesion molecule -0.625332
BBX bobby sox homolog (Drosophila) -0.623807
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -0.623515
FANCL Fanconi anemia, complementation group L -0.622655
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase -0.621818
KCTD2 potassium channel tetramerization domain containing 2 -0.621435
TRIM32 tripartite motif containing 32 -0.62001
TBC1D14 TBC1 domain family, member 14 -0.618873
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae) -0.616683
KANK2 KN motif and ankyrin repeat domains 2 -0.616599
RECQL RecQ helicase-like -0.615465
NR1D2 nuclear receptor subfamily 1, group D, member 2 -0.614818
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 -0.614329
PTPRA protein tyrosine phosphatase, receptor type, A -0.613479
ERCC5 excision repair cross-complementation group 5 -0.611966
PNKD paroxysmal nonkinesigenic dyskinesia -0.61152
TMEM159 transmembrane protein 159 -0.611152
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.609215
KCTD9 potassium channel tetramerization domain containing 9 -0.609072
EMC2 ER membrane protein complex subunit 2 -0.607828
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa -0.602608
ANXA4 annexin A4 -0.601009
CALHM2 calcium homeostasis modulator 2 -0.600642
TMEM204 transmembrane protein 204 -0.598873
LDHB lactate dehydrogenase B -0.596115
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -0.594989
OSTF1 osteoclast stimulating factor 1 -0.594176
RCAN2 regulator of calcineurin 2 -0.593908
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) -0.593481
ZNF22 zinc finger protein 22 -0.58962
JAK1 Janus kinase 1 -0.58877
TMEM218 transmembrane protein 218 -0.586002
CHMP5 charged multivesicular body protein 5 -0.58572
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.585358
RFC2 replication factor C (activator 1) 2, 40kDa -0.584888
MPPE1 metallophosphoesterase 1 -0.584384
AMACR alpha-methylacyl-CoA racemase -0.583444
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -0.581214
SF3B5 splicing factor 3b, subunit 5, 10kDa -0.580497
AFAP1L2 actin filament associated protein 1-like 2 -0.580485
SARAF store-operated calcium entry-associated regulatory factor -0.580336
TXNDC16 thioredoxin domain containing 16 -0.577147
TSC22D3 TSC22 domain family, member 3 -0.576528
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) -0.57643
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 -0.57538