Drug Overdose Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D062787
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Genes

254 genes/proteins associated with the disease Drug Overdose from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
AVP arginine vasopressin 2.88009
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.88009
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.44677
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.44126
CAT catalase 2.41142
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.40778
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 2.37773
TNF tumor necrosis factor 2.3216
FOS FBJ murine osteosarcoma viral oncogene homolog 2.28826
BCL2 B-cell CLL/lymphoma 2 2.28606
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.17886
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 2.17807
MAPK3 mitogen-activated protein kinase 3 2.17108
NOS2 nitric oxide synthase 2, inducible 2.16768
BAX BCL2-associated X protein 2.16728
MAPK1 mitogen-activated protein kinase 1 2.16235
IL1B interleukin 1, beta 2.16131
IL6 interleukin 6 2.12784
REN renin 2.09857
PRL prolactin 2.05307
DRD2 dopamine receptor D2 2.04643
SOD2 superoxide dismutase 2, mitochondrial 2.0445
BDNF brain-derived neurotrophic factor 2.02627
CCL2 chemokine (C-C motif) ligand 2 1.93338
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.91586
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.91468
CREB1 cAMP responsive element binding protein 1 1.90984
GSK3B glycogen synthase kinase 3 beta 1.89011
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.88392
CXCL8 chemokine (C-X-C motif) ligand 8 1.87858
SOD1 superoxide dismutase 1, soluble 1.87109
IFNG interferon, gamma 1.87093
JUN jun proto-oncogene 1.86689
TP53 tumor protein p53 1.86358
IL2 interleukin 2 1.85904
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 1.85695
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.85677
TGFB1 transforming growth factor, beta 1 1.85098
INS insulin 1.84888
POMC proopiomelanocortin 1.84269
APP amyloid beta (A4) precursor protein 1.81976
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.81111
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.80661
IL10 interleukin 10 1.80605
GSTP1 glutathione S-transferase pi 1 1.8051
HMOX1 heme oxygenase 1 1.75875
NOS3 nitric oxide synthase 3 (endothelial cell) 1.7548
FAS Fas cell surface death receptor 1.74119
NPPA natriuretic peptide A 1.73758
MAPK8 mitogen-activated protein kinase 8 1.73332
HRH1 histamine receptor H1 1.73231
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.71524
NPY neuropeptide Y 1.71132
DRD1 dopamine receptor D1 1.70719
VEGFA vascular endothelial growth factor A 1.69576
ACHE acetylcholinesterase (Yt blood group) 1.67804
PARP1 poly (ADP-ribose) polymerase 1 1.67569
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.66857
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.66425
FN1 fibronectin 1 1.65996
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.65996
FASLG Fas ligand (TNF superfamily, member 6) 1.65731
EDN1 endothelin 1 1.65687
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.64303
TAC1 tachykinin, precursor 1 1.62601
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.62401
IL4 interleukin 4 1.61713
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 1.61342
LEP leptin 1.61224
EGR1 early growth response 1 1.60198
IL1A interleukin 1, alpha 1.59544
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 1.59172
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.57281
ADRB1 adrenoceptor beta 1 1.56632
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.56141
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.55946
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.55846
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.55648
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.55599
BCL2L1 BCL2-like 1 1.55329
CRH corticotropin releasing hormone 1.54986
NOS1 nitric oxide synthase 1 (neuronal) 1.54986
TH tyrosine hydroxylase 1.54451
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.53651
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.53209
MAPK9 mitogen-activated protein kinase 9 1.52187
F3 coagulation factor III (thromboplastin, tissue factor) 1.51506
ADRA2A adrenoceptor alpha 2A 1.5103
MPO myeloperoxidase 1.49941
IGF1 insulin-like growth factor 1 (somatomedin C) 1.49711
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.49407
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.49071
SREBF1 sterol regulatory element binding transcription factor 1 1.48068
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.48017
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.47374
GFAP glial fibrillary acidic protein 1.46754
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.46727
NPPB natriuretic peptide B 1.45989
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.45723
ICAM1 intercellular adhesion molecule 1 1.45484
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.45141
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.44382
TIMP1 TIMP metallopeptidase inhibitor 1 1.44084
OPRM1 opioid receptor, mu 1 1.43482
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.43048
NGF nerve growth factor (beta polypeptide) 1.42508
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 1.4098
MAPK14 mitogen-activated protein kinase 14 1.40787
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.40623
ADRA1D adrenoceptor alpha 1D 1.40148
S100A9 S100 calcium binding protein A9 1.3998
FGF2 fibroblast growth factor 2 (basic) 1.39619
CES2 carboxylesterase 2 1.39479
GPX1 glutathione peroxidase 1 1.38412
GSTM1 glutathione S-transferase mu 1 1.381
CCL5 chemokine (C-C motif) ligand 5 1.38015
STAR steroidogenic acute regulatory protein 1.37504
PENK proenkephalin 1.37475
S100A8 S100 calcium binding protein A8 1.37475
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.36161
LHB luteinizing hormone beta polypeptide 1.35473
ADRB2 adrenoceptor beta 2, surface 1.35242
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.34897
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.34459
GCG glucagon 1.34372
CCL3 chemokine (C-C motif) ligand 3 1.3382
CALCA calcitonin-related polypeptide alpha 1.33791
JUNB jun B proto-oncogene 1.31686
PLAT plasminogen activator, tissue 1.31178
TAGLN transgelin 1.31
VCAM1 vascular cell adhesion molecule 1 1.30758
TLR4 toll-like receptor 4 1.30666
EGFR epidermal growth factor receptor 1.30208
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 1.29936
MCL1 myeloid cell leukemia 1 1.29133
CYP3A cytochrome P450, family 3, subfamily A 1.29072
DUSP1 dual specificity phosphatase 1 1.27689
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.27132
PRKCE protein kinase C, epsilon 1.26638
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 1.26638
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.26175
SPP1 secreted phosphoprotein 1 1.26021
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.25899
ACTA2 actin, alpha 2, smooth muscle, aorta 1.24905
COMT catechol-O-methyltransferase 1.24307
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.24307
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.23962
OPRK1 opioid receptor, kappa 1 1.23392
DDIT3 DNA-damage-inducible transcript 3 1.23328
PPARA peroxisome proliferator-activated receptor alpha 1.23011
DRD3 dopamine receptor D3 1.21951
MAOA monoamine oxidase A 1.21631
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.21567
CD151 CD151 molecule (Raph blood group) 1.21435
SELE selectin E 1.21206
MMP2 matrix metallopeptidase 2 1.21141
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.20687
G6PD glucose-6-phosphate dehydrogenase 1.20622
APOE apolipoprotein E 1.20295
INSR insulin receptor 1.19999
GJA1 gap junction protein, alpha 1, 43kDa 1.19966
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.19933
CYCS cytochrome c, somatic 1.19802
VIM vimentin 1.19639
CLU clusterin 1.19639
PRLR prolactin receptor 1.19445
OXT oxytocin/neurophysin I prepropeptide 1.19445
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.19445
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.19312
MAPT microtubule-associated protein tau 1.19312
GNAS GNAS complex locus 1.18915
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 1.18685
CTSL cathepsin L 1.18652
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 1.18391
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.18126
CD44 CD44 molecule (Indian blood group) 1.18093
SST somatostatin 1.18059
CCND1 cyclin D1 1.18026
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.17728
TUBB tubulin, beta class I 1.17366
NR0B2 nuclear receptor subfamily 0, group B, member 2 1.17366
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.17101
FOSL1 FOS-like antigen 1 1.17101
G6PC glucose-6-phosphatase, catalytic subunit 1.17101
ALB albumin 1.16766
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.16733
CP ceruloplasmin (ferroxidase) 1.1617
PRKCD protein kinase C, delta 1.1617
LPL lipoprotein lipase 1.16137
PDGFB platelet-derived growth factor beta polypeptide 1.15627
PPARG peroxisome proliferator-activated receptor gamma 1.15425
ADRA1A adrenoceptor alpha 1A 1.15357
F2 coagulation factor II (thrombin) 1.15189
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 1.15156
FOSL2 FOS-like antigen 2 1.15022
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.14919
PTK2B protein tyrosine kinase 2 beta 1.14713
PRKCB protein kinase C, beta 1.14678
MAOB monoamine oxidase B 1.14678
GADD45A growth arrest and DNA-damage-inducible, alpha 1.14268
EPO erythropoietin 1.142
THBS1 thrombospondin 1 1.13963
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.13895
JAK2 Janus kinase 2 1.13279
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.13041
FABP1 fatty acid binding protein 1, liver 1.12805
PRKCA protein kinase C, alpha 1.12495
CHRM5 cholinergic receptor, muscarinic 5 1.12391
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.12357
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.12288
MYH7 myosin, heavy chain 7, cardiac muscle, beta 1.12219
CDK2 cyclin-dependent kinase 2 1.12117
AOC1 amine oxidase, copper containing 1 1.12048
COL1A1 collagen, type I, alpha 1 1.1198
ADRA1B adrenoceptor alpha 1B 1.11945
IL12B interleukin 12B 1.11707
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 1.10631
EDNRB endothelin receptor type B 1.10631
S100A4 S100 calcium binding protein A4 1.10493
AVPR1A arginine vasopressin receptor 1A 1.10388
H2AFX H2A histone family, member X 1.09927
VIP vasoactive intestinal peptide 1.09611
NUPR1 nuclear protein, transcriptional regulator, 1 1.09119
CDK1 cyclin-dependent kinase 1 1.08833
SREBF2 sterol regulatory element binding transcription factor 2 1.08442
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 1.08231
MGMT O-6-methylguanine-DNA methyltransferase 1.07696
ATM ATM serine/threonine kinase 1.07093
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 1.06917
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 1.06917
CD14 CD14 molecule 1.06698
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 1.06406
ADRA2C adrenoceptor alpha 2C 1.06297
BMP4 bone morphogenetic protein 4 1.059
LBP lipopolysaccharide binding protein 1.05461
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.05274
ADORA1 adenosine A1 receptor 1.05126
HSPB1 heat shock 27kDa protein 1 1.05126
IGFBP5 insulin-like growth factor binding protein 5 1.04868
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 1.04427
TEX261 testis expressed 261 1.03976
MYL9 myosin, light chain 9, regulatory 1.03752
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.03308
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 1.02708
MT1A metallothionein 1A 1.02708
NTF3 neurotrophin 3 1.0241
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.02225
ADRB3 adrenoceptor beta 3 1.02077
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.01966
INHA inhibin, alpha 1.01587
BBC3 BCL2 binding component 3 1.01512
EPHX2 epoxide hydrolase 2, cytoplasmic 1.01512
SCT secretin 1.01137
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.01025