Diabetes Complications Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D048909
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Genes

139 genes/proteins associated with the disease Diabetes Complications from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
HP haptoglobin 2.88009
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 2.88009
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2.88009
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.76888
CAT catalase 1.76424
MAPK3 mitogen-activated protein kinase 3 1.75003
TGFB1 transforming growth factor, beta 1 1.74341
IL1B interleukin 1, beta 1.6906
MMP2 matrix metallopeptidase 2 1.66253
MAPK1 mitogen-activated protein kinase 1 1.66253
TNF tumor necrosis factor 1.65358
CAV1 caveolin 1, caveolae protein, 22kDa 1.60921
NOS2 nitric oxide synthase 2, inducible 1.58724
MPO myeloperoxidase 1.58607
INS insulin 1.57806
MMP9 matrix metallopeptidase 9 1.57735
IL6 interleukin 6 1.57474
NOS3 nitric oxide synthase 3 (endothelial cell) 1.56459
GSR glutathione reductase 1.55059
SOD2 superoxide dismutase 2, mitochondrial 1.52212
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 1.49915
BAX BCL2-associated X protein 1.49482
EDN1 endothelin 1 1.48531
ALB albumin 1.474
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.47115
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.46935
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.46015
LEP leptin 1.44681
TLR4 toll-like receptor 4 1.42293
HMOX1 heme oxygenase 1 1.41119
CYBA cytochrome b-245, alpha polypeptide 1.40953
ADIPOQ adiponectin, C1Q and collagen domain containing 1.40429
AGER advanced glycosylation end product-specific receptor 1.3998
IRS1 insulin receptor substrate 1 1.39591
IFNG interferon, gamma 1.3931
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.38185
SPHK1 sphingosine kinase 1 1.37874
MAPK9 mitogen-activated protein kinase 9 1.37789
EP300 E1A binding protein p300 1.37132
S100B S100 calcium binding protein B 1.35934
DDIT3 DNA-damage-inducible transcript 3 1.35877
ACE angiotensin I converting enzyme 1.35299
BCL2 B-cell CLL/lymphoma 2 1.34926
GPX1 glutathione peroxidase 1 1.34256
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.33909
VEGFA vascular endothelial growth factor A 1.32339
PRKCA protein kinase C, alpha 1.31476
INSR insulin receptor 1.31387
CRP C-reactive protein, pentraxin-related 1.3085
ALAD aminolevulinate dehydratase 1.30208
SOD1 superoxide dismutase 1, soluble 1.29657
XDH xanthine dehydrogenase 1.28734
ICAM1 intercellular adhesion molecule 1 1.28149
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.28027
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.2744
APP amyloid beta (A4) precursor protein 1.27224
NFE2L2 nuclear factor, erythroid 2-like 2 1.26947
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.26576
CYBB cytochrome b-245, beta polypeptide 1.26576
HSPB1 heat shock 27kDa protein 1 1.26113
TXN thioredoxin 1.25745
LHB luteinizing hormone beta polypeptide 1.25682
CCL2 chemokine (C-C motif) ligand 2 1.25682
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 1.24433
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.23806
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.23616
PPARA peroxisome proliferator-activated receptor alpha 1.2352
IL12B interleukin 12B 1.23106
ATF4 activating transcription factor 4 1.22145
AHR aryl hydrocarbon receptor 1.21631
CREB1 cAMP responsive element binding protein 1 1.21435
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 1.20427
ERN1 endoplasmic reticulum to nucleus signaling 1 1.20328
PRKCD protein kinase C, delta 1.19999
MAP3K5 mitogen-activated protein kinase kinase kinase 5 1.19868
PARP1 poly (ADP-ribose) polymerase 1 1.19509
NOS1 nitric oxide synthase 1 (neuronal) 1.18915
KDR kinase insert domain receptor 1.18259
SIRT1 sirtuin 1 1.18159
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.18026
BCL2L1 BCL2-like 1 1.17761
IL10 interleukin 10 1.16967
B2M beta-2-microglobulin 1.16866
NOX4 NADPH oxidase 4 1.16866
NGF nerve growth factor (beta polypeptide) 1.16633
CTGF connective tissue growth factor 1.16137
MMP1 matrix metallopeptidase 1 1.16137
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.15695
PLAT plasminogen activator, tissue 1.1556
IL5 interleukin 5 1.15526
FOS FBJ murine osteosarcoma viral oncogene homolog 1.15022
SOD3 superoxide dismutase 3, extracellular 1.14713
CXCL8 chemokine (C-X-C motif) ligand 8 1.13862
G6PC glucose-6-phosphatase, catalytic subunit 1.13793
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.13758
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.13449
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.13381
FAS Fas cell surface death receptor 1.13279
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 1.13245
NQO1 NAD(P)H dehydrogenase, quinone 1 1.12391
PPARG peroxisome proliferator-activated receptor gamma 1.12357
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.12254
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.12254
SMAD3 SMAD family member 3 1.11707
RHOA ras homolog family member A 1.11536
IGF1 insulin-like growth factor 1 (somatomedin C) 1.11501
FTH1 ferritin, heavy polypeptide 1 1.10699
SMAD4 SMAD family member 4 1.09892
FN1 fibronectin 1 1.09047
TP53 tumor protein p53 1.08904
JUN jun proto-oncogene 1.08904
AGTR1 angiotensin II receptor, type 1 1.08762
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.08655
NCF1 neutrophil cytosolic factor 1 1.08196
MAPK8 mitogen-activated protein kinase 8 1.07947
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.07911
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 1.07911
POU5F1 POU class 5 homeobox 1 1.07911
XBP1 X-box binding protein 1 1.07625
ESR1 estrogen receptor 1 1.06333
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.05972
GSK3B glycogen synthase kinase 3 beta 1.05972
MMP3 matrix metallopeptidase 3 1.05757
NTS neurotensin 1.05648
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.05648
CXCL2 chemokine (C-X-C motif) ligand 2 1.05423
SPP1 secreted phosphoprotein 1 1.05237
COL1A2 collagen, type I, alpha 2 1.052
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 1.05126
MME membrane metallo-endopeptidase 1.04868
ATF6 activating transcription factor 6 1.04647
GFAP glial fibrillary acidic protein 1.04389
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 1.04276
REN renin 1.03901
NCF2 neutrophil cytosolic factor 2 1.03271
MT2A metallothionein 2A 1.03197
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.02596
HSF1 heat shock transcription factor 1 1.01512
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.01324