Dementia Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior. (Human Disease Ontology, DOID_1307)
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Genes

170 genes associated with the Dementia phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACAT1 acetyl-CoA acetyltransferase 1
ACAT2 acetyl-CoA acetyltransferase 2
ACE angiotensin I converting enzyme
AGER advanced glycosylation end product-specific receptor
AHR aryl hydrocarbon receptor
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APCS amyloid P component, serum
APOA1 apolipoprotein A-I
APOB apolipoprotein B
APOC1 apolipoprotein C-I
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
ASTN2 astrotactin 2
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
BACE1 beta-site APP-cleaving enzyme 1
BCHE butyrylcholinesterase
BDNF brain-derived neurotrophic factor
BIN1 bridging integrator 1
C9ORF72 chromosome 9 open reading frame 72
CCL2 chemokine (C-C motif) ligand 2
CCL8 chemokine (C-C motif) ligand 8
CD2AP CD2-associated protein
CD33 CD33 molecule
CDK1 cyclin-dependent kinase 1
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CETP cholesteryl ester transfer protein, plasma
CHMP2B charged multivesicular body protein 2B
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
CHRM2 cholinergic receptor, muscarinic 2
CLU clusterin
COMT catechol-O-methyltransferase
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRP C-reactive protein, pentraxin-related
CTSD cathepsin D
CXCL8 chemokine (C-X-C motif) ligand 8
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DCTN1 dynactin 1
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1
DPP4 dipeptidyl-peptidase 4
DRD4 dopamine receptor D4
DRP2 dystrophin related protein 2
EPHA1 EPH receptor A1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FBXW8 F-box and WD repeat domain containing 8
FMR1 fragile X mental retardation 1
FOLR1 folate receptor 1 (adult)
FUS FUS RNA binding protein
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GBA glucosidase, beta, acid
GCKR glucokinase (hexokinase 4) regulator
GRN granulin
GSK3B glycogen synthase kinase 3 beta
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HFE hemochromatosis
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB3 major histocompatibility complex, class II, DR beta 3
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HLA-DRB5 major histocompatibility complex, class II, DR beta 5
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HRK harakiri, BCL2 interacting protein
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSPA1A heat shock 70kDa protein 1A
IGF1R insulin-like growth factor 1 receptor
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
LCAT lecithin-cholesterol acyltransferase
LDLR low density lipoprotein receptor
LIPC lipase, hepatic
LIPG lipase, endothelial
LMNA lamin A/C
LPL lipoprotein lipase
LRP1 low density lipoprotein receptor-related protein 1
LRP2 low density lipoprotein receptor-related protein 2
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LRRC16A leucine rich repeat containing 16A
LRRK2 leucine-rich repeat kinase 2
MAOA monoamine oxidase A
MAPT microtubule-associated protein tau
MASP2 mannan-binding lectin serine peptidase 2
MLXIPL MLX interacting protein-like
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MSRB3 methionine sulfoxide reductase B3
MT-ND2 MTND2
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
ND1
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH3 notch 3
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR1I3 nuclear receptor subfamily 1, group I, member 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NT3 3'-nucleotidase
PARK7 parkinson protein 7
PCSK9 proprotein convertase subtilisin/kexin type 9
PDZK1 PDZ domain containing 1
PICALM phosphatidylinositol binding clathrin assembly protein
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLTP phospholipid transfer protein
PON1 paraoxonase 1
POR P450 (cytochrome) oxidoreductase
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PRNP prion protein
PSEN1 presenilin 1
PSEN2 presenilin 2
PSRC1 proline/serine-rich coiled-coil 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
REST RE1-silencing transcription factor
RUNX1 runt-related transcription factor 1
S100B S100 calcium binding protein B
SAA1 serum amyloid A1
SCARB1 scavenger receptor class B, member 1
SERPINA13P serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 13, pseudogene
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A9 solute carrier family 16, member 9
SLC17A1 solute carrier family 17 (organic anion transporter), member 1
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC7A4 solute carrier family 7, member 4
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD1 superoxide dismutase 1, soluble
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SORT1 sortilin 1
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
STH saitohin
TARDBP TAR DNA binding protein
TFAM transcription factor A, mitochondrial
TGFB1 transforming growth factor, beta 1
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TOM1L2 target of myb1-like 2 (chicken)
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TYMS thymidylate synthetase
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCP valosin containing protein
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VIMP VCP-interacting membrane selenoprotein
VLDLR very low density lipoprotein receptor
WIF1 WNT inhibitory factor 1