DMS 454 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: carcinoma, small cell (Cell Line Ontology, CLO_0002798)
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247 genes mutated in the DMS 454 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ACIN1 apoptotic chromatin condensation inducer 1
ADCY2 adenylate cyclase 2 (brain)
ALG9 ALG9, alpha-1,2-mannosyltransferase
AMER3 APC membrane recruitment protein 3
ANK2 ankyrin 2, neuronal
ANKRD12 ankyrin repeat domain 12
ANKRD45 ankyrin repeat domain 45
ANO8 anoctamin 8
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGAP21 Rho GTPase activating protein 21
ARID5B AT rich interactive domain 5B (MRF1-like)
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ASB16-AS1 ASB16 antisense RNA 1
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP13A3 ATPase type 13A3
ATR ATR serine/threonine kinase
BAG6 BCL2-associated athanogene 6
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL6 B-cell CLL/lymphoma 6
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
BHMT betaine--homocysteine S-methyltransferase
BIVM-ERCC5 BIVM-ERCC5 readthrough
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C1ORF159 chromosome 1 open reading frame 159
CBFB core-binding factor, beta subunit
CCDC108 coiled-coil domain containing 108
CCDC124 coiled-coil domain containing 124
CCDC15 coiled-coil domain containing 15
CCNA2 cyclin A2
CCNH cyclin H
CDH7 cadherin 7, type 2
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEP63 centrosomal protein 63kDa
CFAP61 cilia and flagella associated protein 61
CHRM3 cholinergic receptor, muscarinic 3
CIT citron rho-interacting serine/threonine kinase
CLOCK clock circadian regulator
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CNOT3 CCR4-NOT transcription complex, subunit 3
CNR1 cannabinoid receptor 1 (brain)
CRCP CGRP receptor component
CSMD2 CUB and Sushi multiple domains 2
CTTNBP2NL CTTNBP2 N-terminal like
DBF4 DBF4 zinc finger
DENND5B DENN/MADD domain containing 5B
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
DMD dystrophin
DNHD1 dynein heavy chain domain 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOCK7 dedicator of cytokinesis 7
DPF2 D4, zinc and double PHD fingers family 2
DPY19L3 dpy-19-like 3 (C. elegans)
DSC3 desmocollin 3
DUS1L dihydrouridine synthase 1-like (S. cerevisiae)
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EAF2 ELL associated factor 2
ECE2 endothelin converting enzyme 2
EGFR epidermal growth factor receptor
ELAVL3 ELAV like neuron-specific RNA binding protein 3
ENTHD2 ENTH domain containing 2
EPRS glutamyl-prolyl-tRNA synthetase
ERCC5 excision repair cross-complementation group 5
ERICH1 glutamate-rich 1
ETV3 ets variant 3
EVC2 Ellis van Creveld syndrome 2
F11R F11 receptor
F5 coagulation factor V (proaccelerin, labile factor)
FAM162B family with sequence similarity 162, member B
FAM171A1 family with sequence similarity 171, member A1
FAM195B family with sequence similarity 195, member B
FAM83E family with sequence similarity 83, member E
FAM96B family with sequence similarity 96, member B
FDXR ferredoxin reductase
FEM1C fem-1 homolog c (C. elegans)
FERMT1 fermitin family member 1
FOXD1 forkhead box D1
FRMPD1 FERM and PDZ domain containing 1
FSTL4 follistatin-like 4
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GFI1 growth factor independent 1 transcription repressor
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GMNN geminin, DNA replication inhibitor
GPATCH2 G patch domain containing 2
GPATCH8 G patch domain containing 8
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2
GREB1L growth regulation by estrogen in breast cancer-like
GRPR gastrin-releasing peptide receptor
HCFC1 host cell factor C1
HELB helicase (DNA) B
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2
HOXA4 homeobox A4
HTT huntingtin
HYDIN HYDIN, axonemal central pair apparatus protein
IHH indian hedgehog
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
IREB2 iron-responsive element binding protein 2
KAT6A K(lysine) acetyltransferase 6A
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4
KCTD12 potassium channel tetramerization domain containing 12
KDM1B lysine (K)-specific demethylase 1B
KEAP1 kelch-like ECH-associated protein 1
KIAA0355 KIAA0355
KIAA0556 KIAA0556
KIF21A kinesin family member 21A
KLHL26 kelch-like family member 26
KLHL32 kelch-like family member 32
LAMC1 laminin, gamma 1 (formerly LAMB2)
LDHB lactate dehydrogenase B
LENG8 leukocyte receptor cluster (LRC) member 8
LONP2 lon peptidase 2, peroxisomal
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MDN1 MDN1, midasin homolog (yeast)
MED25 mediator complex subunit 25
MUC4 mucin 4, cell surface associated
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
MYO7A myosin VIIA
MYO7B myosin VIIB
MYO9B myosin IXB
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1
NAP1L4 nucleosome assembly protein 1-like 4
NAT10 N-acetyltransferase 10 (GCN5-related)
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa
NES nestin
NIPBL Nipped-B homolog (Drosophila)
NKX1-2 NK1 homeobox 2
NOTCH2 notch 2
NOX4 NADPH oxidase 4
NPC1L1 NPC1-like 1
NRXN1 neurexin 1
NSD1 nuclear receptor binding SET domain protein 1
NUP210 nucleoporin 210kDa
NUP85 nucleoporin 85kDa
OCA2 oculocutaneous albinism II
ODF2 outer dense fiber of sperm tails 2
OPRL1 opiate receptor-like 1
OPTN optineurin
OR10G2 olfactory receptor, family 10, subfamily G, member 2
ORC1 origin recognition complex, subunit 1
OSBP oxysterol binding protein
OXCT1 3-oxoacid CoA transferase 1
PCDHB6 protocadherin beta 6
PCDHGA7 protocadherin gamma subfamily A, 7
PDIA4 protein disulfide isomerase family A, member 4
PFKL phosphofructokinase, liver
PI4KB phosphatidylinositol 4-kinase, catalytic, beta
PIEZO2 piezo-type mechanosensitive ion channel component 2
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1
PLCG1 phospholipase C, gamma 1
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
PLXNB1 plexin B1
PNPLA7 patatin-like phospholipase domain containing 7
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLQ polymerase (DNA directed), theta
POU6F2 POU class 6 homeobox 2
PPP1R9B protein phosphatase 1, regulatory subunit 9B
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRKCSH protein kinase C substrate 80K-H
PRTFDC1 phosphoribosyl transferase domain containing 1
PTPN9 protein tyrosine phosphatase, non-receptor type 9
QSOX2 quiescin Q6 sulfhydryl oxidase 2
RABL6 RAB, member RAS oncogene family-like 6
RAD50 RAD50 homolog (S. cerevisiae)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RFX7 regulatory factor X, 7
RIMS2 regulating synaptic membrane exocytosis 2
RLF rearranged L-myc fusion
RNF169 ring finger protein 169
RNF20 ring finger protein 20, E3 ubiquitin protein ligase
RUSC1 RUN and SH3 domain containing 1
RYR2 ryanodine receptor 2 (cardiac)
SAMD9L sterile alpha motif domain containing 9-like
SCFD1 sec1 family domain containing 1
SCN2A sodium channel, voltage gated, type II alpha subunit
SDE2 SDE2 telomere maintenance homolog (S. pombe)
SENP7 SUMO1/sentrin specific peptidase 7
SEPHS2 selenophosphate synthetase 2
SEPT8 septin 8
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SIK3 SIK family kinase 3
SLC35E2 solute carrier family 35, member E2
SLC38A6 solute carrier family 38, member 6
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLITRK5 SLIT and NTRK-like family, member 5
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SON SON DNA binding protein
SOS2 son of sevenless homolog 2 (Drosophila)
SP1 Sp1 transcription factor
SPATA13 spermatogenesis associated 13
SPG20 spastic paraplegia 20 (Troyer syndrome)
SRRM5 serine/arginine repetitive matrix 5
ST18 suppression of tumorigenicity 18, zinc finger
STRN striatin, calmodulin binding protein
SYNE3 spectrin repeat containing, nuclear envelope family member 3
TBC1D7 TBC1 domain family, member 7
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TDRD1 tudor domain containing 1
TENM1 teneurin transmembrane protein 1
TENM3 teneurin transmembrane protein 3
THAP9 THAP domain containing 9
TMCO3 transmembrane and coiled-coil domains 3
TMEM185A transmembrane protein 185A
TMEM219 transmembrane protein 219
TMEM63B transmembrane protein 63B
TNPO2 transportin 2
TP53 tumor protein p53
TRAPPC9 trafficking protein particle complex 9
TREML4 triggering receptor expressed on myeloid cells-like 4
TRIP11 thyroid hormone receptor interactor 11
TRMT10C tRNA methyltransferase 10 homolog C (S. cerevisiae)
TSHZ1 teashirt zinc finger homeobox 1
TSNARE1 t-SNARE domain containing 1
TTC37 tetratricopeptide repeat domain 37
TTC9 tetratricopeptide repeat domain 9
TTYH2 tweety family member 2
UNC79 unc-79 homolog (C. elegans)
UQCRH ubiquinol-cytochrome c reductase hinge protein
USP31 ubiquitin specific peptidase 31
VASH2 vasohibin 2
VPS33B vacuolar protein sorting 33 homolog B (yeast)
WDR26 WD repeat domain 26
WNK1 WNK lysine deficient protein kinase 1
XPO6 exportin 6
ZBTB26 zinc finger and BTB domain containing 26
ZDHHC11 zinc finger, DHHC-type containing 11
ZKSCAN8 zinc finger with KRAB and SCAN domains 8
ZNF266 zinc finger protein 266
ZNF268 zinc finger protein 268
ZNF420 zinc finger protein 420
ZNF510 zinc finger protein 510
ZNF530 zinc finger protein 530
ZNF564 zinc finger protein 564
ZNF579 zinc finger protein 579
ZNF616 zinc finger protein 616
ZNF749 zinc finger protein 749
ZNF771 zinc finger protein 771
ZNF827 zinc finger protein 827
ZNF850 zinc finger protein 850
ZSCAN18 zinc finger and SCAN domain containing 18
ZSCAN26 zinc finger and SCAN domain containing 26