Consciousness Disorders Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D003244
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Genes

311 genes/proteins associated with the disease Consciousness Disorders from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.09533
BCL2 B-cell CLL/lymphoma 2 2.06822
FOS FBJ murine osteosarcoma viral oncogene homolog 2.02557
MAPK1 mitogen-activated protein kinase 1 2.02487
TNF tumor necrosis factor 2.0139
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.972
JUN jun proto-oncogene 1.967
BDNF brain-derived neurotrophic factor 1.95903
BAX BCL2-associated X protein 1.95661
NPY neuropeptide Y 1.89796
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.88059
MAPK3 mitogen-activated protein kinase 3 1.86924
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.86689
BCL2L1 BCL2-like 1 1.8608
IL6 interleukin 6 1.85695
DDIT3 DNA-damage-inducible transcript 3 1.84941
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.84835
CAT catalase 1.84552
PRL prolactin 1.83503
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.82761
EGR1 early growth response 1 1.80153
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.79694
TAC1 tachykinin, precursor 1 1.77199
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.75063
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.71871
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.7181
SOD2 superoxide dismutase 2, mitochondrial 1.68358
PARP1 poly (ADP-ribose) polymerase 1 1.67868
POR P450 (cytochrome) oxidoreductase 1.67761
DRD2 dopamine receptor D2 1.65489
TP53 tumor protein p53 1.63989
FAS Fas cell surface death receptor 1.63227
HSPA8 heat shock 70kDa protein 8 1.63049
IL1B interleukin 1, beta 1.62335
GSTP1 glutathione S-transferase pi 1 1.61782
GSK3B glycogen synthase kinase 3 beta 1.61224
GADD45A growth arrest and DNA-damage-inducible, alpha 1.58865
TH tyrosine hydroxylase 1.58678
HSPB1 heat shock 27kDa protein 1 1.58444
MBP myelin basic protein 1.58184
CXCL10 chemokine (C-X-C motif) ligand 10 1.57947
ADORA1 adenosine A1 receptor 1.56484
HMOX1 heme oxygenase 1 1.56044
GSTM1 glutathione S-transferase mu 1 1.55673
GAL galanin/GMAP prepropeptide 1.54499
PENK proenkephalin 1.54062
CCL2 chemokine (C-C motif) ligand 2 1.54038
ARC activity-regulated cytoskeleton-associated protein 1.53941
BBC3 BCL2 binding component 3 1.53481
VEGFA vascular endothelial growth factor A 1.52865
POMC proopiomelanocortin 1.52667
CCND1 cyclin D1 1.52287
CRH corticotropin releasing hormone 1.51986
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.5118
BAK1 BCL2-antagonist/killer 1 1.50373
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.49762
UNG uracil-DNA glycosylase 1.49762
F3 coagulation factor III (thromboplastin, tissue factor) 1.49174
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.48633
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.48454
MAPK8 mitogen-activated protein kinase 8 1.47864
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.47012
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.46961
NOS2 nitric oxide synthase 2, inducible 1.4633
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.46015
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.46015
CTSL cathepsin L 1.45431
GFAP glial fibrillary acidic protein 1.45352
CXCL8 chemokine (C-X-C motif) ligand 8 1.44899
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.44763
FN1 fibronectin 1 1.44517
MAPK14 mitogen-activated protein kinase 14 1.44409
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.44139
IL2 interleukin 2 1.43347
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.42994
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.42967
ICAM1 intercellular adhesion molecule 1 1.42589
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 1.42535
JUNB jun B proto-oncogene 1.41146
BAD BCL2-associated agonist of cell death 1.40595
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.40486
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.40486
CFLAR CASP8 and FADD-like apoptosis regulator 1.40064
IFNG interferon, gamma 1.39591
FASLG Fas ligand (TNF superfamily, member 6) 1.39535
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.38641
DRD1 dopamine receptor D1 1.38441
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.38327
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.37103
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.3699
HSPA1A heat shock 70kDa protein 1A 1.3699
DRD4 dopamine receptor D4 1.35962
ADORA2A adenosine A2a receptor 1.35647
NR1I3 nuclear receptor subfamily 1, group I, member 3 1.34489
GRIA2 glutamate receptor, ionotropic, AMPA 2 1.34489
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.33761
IL10 interleukin 10 1.33583
FMO1 flavin containing monooxygenase 1 1.33375
REN renin 1.32786
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 1.32726
NOS1 nitric oxide synthase 1 (neuronal) 1.32607
TRPV1 transient receptor potential cation channel, subfamily V, member 1 1.32015
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.31897
EGR2 early growth response 2 1.31656
INS insulin 1.31566
CALCA calcitonin-related polypeptide alpha 1.30881
CES2 carboxylesterase 2 1.30819
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.30819
GSTT1 glutathione S-transferase theta 1 1.30574
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.3039
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.29657
MMP9 matrix metallopeptidase 9 1.29657
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 1.29626
PRKCE protein kinase C, epsilon 1.2941
TLR4 toll-like receptor 4 1.28364
RGS4 regulator of G-protein signaling 4 1.28333
PPARG peroxisome proliferator-activated receptor gamma 1.28272
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.28241
NPPA natriuretic peptide A 1.27813
TGFB1 transforming growth factor, beta 1 1.27657
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.27502
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.27316
MAP2 microtubule-associated protein 2 1.27193
MCL1 myeloid cell leukemia 1 1.27162
KRT8 keratin 8, type II 1.26763
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 1.26083
COL3A1 collagen, type III, alpha 1 1.26052
DUSP1 dual specificity phosphatase 1 1.26021
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.25899
OPRM1 opioid receptor, mu 1 1.25713
CNR1 cannabinoid receptor 1 (brain) 1.24843
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.24528
LHB luteinizing hormone beta polypeptide 1.24433
PDYN prodynorphin 1.24275
CX3CL1 chemokine (C-X3-C motif) ligand 1 1.24275
BID BH3 interacting domain death agonist 1.23584
APP amyloid beta (A4) precursor protein 1.2352
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.2352
DHCR24 24-dehydrocholesterol reductase 1.23042
VLDLR very low density lipoprotein receptor 1.23042
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 1.23011
MMP3 matrix metallopeptidase 3 1.22048
HMBS hydroxymethylbilane synthase 1.21919
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.21599
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 1.21435
ATF3 activating transcription factor 3 1.21402
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.21271
PRKCD protein kinase C, delta 1.20978
ZNF207 zinc finger protein 207 1.20719
HRH1 histamine receptor H1 1.20687
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.20526
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.19999
CREB1 cAMP responsive element binding protein 1 1.19639
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.19345
SRM spermidine synthase 1.19279
PRLR prolactin receptor 1.19146
OXT oxytocin/neurophysin I prepropeptide 1.19113
CCL5 chemokine (C-C motif) ligand 5 1.19113
ALB albumin 1.18783
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1.18587
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 1.18059
NOS3 nitric oxide synthase 3 (endothelial cell) 1.18026
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 1.17926
IL4 interleukin 4 1.1786
AVP arginine vasopressin 1.1786
NQO1 NAD(P)H dehydrogenase, quinone 1 1.17827
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.17662
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 1.17563
IGFBP5 insulin-like growth factor binding protein 5 1.17464
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 1.17333
PCBP1 poly(rC) binding protein 1 1.173
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.17235
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.17202
RELN reelin 1.16933
LYN LYN proto-oncogene, Src family tyrosine kinase 1.16269
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.16104
ATF5 activating transcription factor 5 1.15967
PLAT plasminogen activator, tissue 1.15967
IL18 interleukin 18 1.15967
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 1.15661
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 1.15357
PRKCB protein kinase C, beta 1.1529
VIM vimentin 1.15055
LPIN1 lipin 1 1.15022
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.14919
GPX2 glutathione peroxidase 2 1.14919
FGF2 fibroblast growth factor 2 (basic) 1.14919
THBS1 thrombospondin 1 1.14713
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 1.1437
BCL6B B-cell CLL/lymphoma 6, member B 1.14336
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 1.14132
DUSP6 dual specificity phosphatase 6 1.13963
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 1.13793
NPPB natriuretic peptide B 1.13793
COL1A1 collagen, type I, alpha 1 1.13655
MAP2K2 mitogen-activated protein kinase kinase 2 1.13621
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.13518
VCAM1 vascular cell adhesion molecule 1 1.13484
ODC1 ornithine decarboxylase 1 1.13381
SELL selectin L 1.13279
ADA adenosine deaminase 1.13245
COL18A1 collagen, type XVIII, alpha 1 1.13245
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.13245
RB1 retinoblastoma 1 1.13007
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.1294
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 1.12703
NME1 NME/NM23 nucleoside diphosphate kinase 1 1.11877
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 1.11741
ADCY6 adenylate cyclase 6 1.11741
GLRB glycine receptor, beta 1.11501
SOCS3 suppressor of cytokine signaling 3 1.1136
CCK cholecystokinin 1.11116
CAPN2 calpain 2, (m/II) large subunit 1.11081
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.10838
NUPR1 nuclear protein, transcriptional regulator, 1 1.10838
SGK1 serum/glucocorticoid regulated kinase 1 1.10838
IGFBP4 insulin-like growth factor binding protein 4 1.10803
ATF6 activating transcription factor 6 1.10803
EGR4 early growth response 4 1.10769
MMP13 matrix metallopeptidase 13 1.10699
IL1A interleukin 1, alpha 1.10211
ERBB2 erb-b2 receptor tyrosine kinase 2 1.10175
GSTA2 glutathione S-transferase alpha 2 1.10069
GATA3 GATA binding protein 3 1.10033
INHBE inhibin, beta E 1.09786
GSTM3 glutathione S-transferase mu 3 (brain) 1.09716
NFE2L2 nuclear factor, erythroid 2-like 2 1.09646
PER2 period circadian clock 2 1.09541
PHGDH phosphoglycerate dehydrogenase 1.09506
PKLR pyruvate kinase, liver and RBC 1.09506
EXOG endo/exonuclease (5'-3'), endonuclease G-like 1.09366
EDN1 endothelin 1 1.09297
PMP22 peripheral myelin protein 22 1.09297
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.09226
CDK2 cyclin-dependent kinase 2 1.0919
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 1.09047
NPR1 natriuretic peptide receptor 1 1.0894
EFHD1 EF-hand domain family, member D1 1.08904
GAP43 growth associated protein 43 1.08797
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.08726
MPO myeloperoxidase 1.0869
GBP1 guanylate binding protein 1, interferon-inducible 1.08513
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 1.08478
TMEM125 transmembrane protein 125 1.08301
CTSD cathepsin D 1.08126
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 1.07696
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 1.0766
SDS serine dehydratase 1.07625
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.07589
NCAN neurocan 1.07482
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 1.07376
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 1.0734
S100A4 S100 calcium binding protein A4 1.06917
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.06881
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 1.06844
GPX1 glutathione peroxidase 1 1.06808
GATA5 GATA binding protein 5 1.06479
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 1.06442
EGFR epidermal growth factor receptor 1.06297
MMP2 matrix metallopeptidase 2 1.06116
DLAT dihydrolipoamide S-acetyltransferase 1.06008
ALDOA aldolase A, fructose-bisphosphate 1.05972
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.059
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) 1.05757
FBXL3 F-box and leucine-rich repeat protein 3 1.05573
DPF1 D4, zinc and double PHD fingers family 1 1.05535
IGFBP3 insulin-like growth factor binding protein 3 1.05461
MSMO1 methylsterol monooxygenase 1 1.05312
NRP1 neuropilin 1 1.05312
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 1.052
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 1.05126
COMT catechol-O-methyltransferase 1.05015
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1.05015
LEP leptin 1.04941
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.04904
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.04904
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae) 1.04465
RAMP1 receptor (G protein-coupled) activity modifying protein 1 1.04465
TIMP1 TIMP metallopeptidase inhibitor 1 1.04352
F2R coagulation factor II (thrombin) receptor 1.04014
REPIN1 replication initiator 1 1.03901
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 1.03789
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.03752
GRM1 glutamate receptor, metabotropic 1 1.03752
BIRC5 baculoviral IAP repeat containing 5 1.03752
OLFML3 olfactomedin-like 3 1.03715
FMO2 flavin containing monooxygenase 2 (non-functional) 1.03715
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.03604
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.0353
MAP2K1 mitogen-activated protein kinase kinase 1 1.03493
NGF nerve growth factor (beta polypeptide) 1.03493
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.03382
OAT ornithine aminotransferase 1.03382
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.03345
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 1.03197
BMP4 bone morphogenetic protein 4 1.03197
ALAD aminolevulinate dehydratase 1.03197
FNDC3A fibronectin type III domain containing 3A 1.03122
CRHR1 corticotropin releasing hormone receptor 1 1.03084
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.03009
CTGF connective tissue growth factor 1.02933
CCKBR cholecystokinin B receptor 1.02746
SNAP25 synaptosomal-associated protein, 25kDa 1.02708
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 1.02559
C10ORF10 chromosome 10 open reading frame 10 1.02336
RND2 Rho family GTPase 2 1.02336
H2AFX H2A histone family, member X 1.02299
S100A9 S100 calcium binding protein A9 1.02188
CALB1 calbindin 1, 28kDa 1.01966
APOE apolipoprotein E 1.0189
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 1.01025