Complement cascade Gene Set

Dataset Reactome Pathways
Category structural or functional annotations
Type pathway
Description Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway. (Gene Ontology, GO_0006956)
External Link http://www.reactome.org/PathwayBrowser/#/R-HSA-166658
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Genes

72 proteins participating in the Complement cascade pathway from the Reactome Pathways dataset.

Symbol Name
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C1QC complement component 1, q subcomponent, C chain
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C2 complement component 2
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
C4B complement component 4B (Chido blood group)
C4BPA complement component 4 binding protein, alpha
C4BPB complement component 4 binding protein, beta
C5 complement component 5
C6 complement component 6
C7 complement component 7
C8A complement component 8, alpha polypeptide
C8B complement component 8, beta polypeptide
C8G complement component 8, gamma polypeptide
C9 complement component 9
CD46 CD46 molecule, complement regulatory protein
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CFB complement factor B
CFD complement factor D (adipsin)
CFH complement factor H
CFHR3 complement factor H-related 3
CFI complement factor I
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRP C-reactive protein, pentraxin-related
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FCN3 ficolin (collagen/fibrinogen domain containing) 3
GZMM granzyme M (lymphocyte met-ase 1)
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGHG2 immunoglobulin heavy constant gamma 2 (G2m marker)
IGHG3 immunoglobulin heavy constant gamma 3 (G3m marker)
IGHG4 immunoglobulin heavy constant gamma 4 (G4m marker)
IGHV7-81 immunoglobulin heavy variable 7-81 (non-functional)
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLC1 immunoglobulin lambda constant 1 (Mcg marker)
IGLC2 immunoglobulin lambda constant 2 (Kern-Oz- marker)
IGLC3 immunoglobulin lambda constant 3 (Kern-Oz+ marker)
IGLC6 immunoglobulin lambda constant 6 (Kern+Oz- marker, gene/pseudogene)
IGLC7 immunoglobulin lambda constant 7
IGLV1-36 immunoglobulin lambda variable 1-36
IGLV1-40 immunoglobulin lambda variable 1-40
IGLV1-44 immunoglobulin lambda variable 1-44
IGLV10-54 immunoglobulin lambda variable 10-54
IGLV11-55 immunoglobulin lambda variable 11-55 (non-functional)
IGLV2-11 immunoglobulin lambda variable 2-11
IGLV2-18 immunoglobulin lambda variable 2-18
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV2-33 immunoglobulin lambda variable 2-33 (non-functional)
IGLV3-12 immunoglobulin lambda variable 3-12
IGLV3-16 immunoglobulin lambda variable 3-16
IGLV3-22 immunoglobulin lambda variable 3-22 (gene/pseudogene)
IGLV3-25 immunoglobulin lambda variable 3-25
IGLV3-27 immunoglobulin lambda variable 3-27
IGLV4-3 immunoglobulin lambda variable 4-3
IGLV4-60 immunoglobulin lambda variable 4-60
IGLV4-69 immunoglobulin lambda variable 4-69
IGLV5-37 immunoglobulin lambda variable 5-37
IGLV5-45 immunoglobulin lambda variable 5-45
IGLV7-43 immunoglobulin lambda variable 7-43
IGLV7-46 immunoglobulin lambda variable 7-46 (gene/pseudogene)
IGLV8-61 immunoglobulin lambda variable 8-61
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MASP2 mannan-binding lectin serine peptidase 2
MBL2 mannose-binding lectin (protein C) 2, soluble
PROS1 protein S (alpha)
VTN vitronectin