Chromosome Breakage Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A type of chromosomal aberration characterized by an increased susceptibility to chromosomal breakage induced by treatment of cultured lymphocytes with agents such as chemical mutagens, irradiation, and alkylating agents. (Human Phenotype Ontology, HP_0003220)
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Genes

21 genes associated with the Chromosome Breakage phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
BCR breakpoint cluster region
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BSPRY B-box and SPRY domain containing
CCL2 chemokine (C-C motif) ligand 2
FANCA Fanconi anemia, complementation group A
FANCC Fanconi anemia, complementation group C
FANCG Fanconi anemia, complementation group G
FH fumarate hydratase
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
MED12 mediator complex subunit 12
NBN nibrin
NSD1 nuclear receptor binding SET domain protein 1
OGG1 8-oxoguanine DNA glycosylase
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
TP53 tumor protein p53
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4