Chromosome Breakage Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A type of chromosomal aberration characterized by an increased susceptibility to chromosomal breakage induced by treatment of cultured lymphocytes with agents such as chemical mutagens, irradiation, and alkylating agents. (Human Phenotype Ontology, HP_0003220)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D019457
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Genes

187 genes/proteins associated with the disease Chromosome Breakage from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
BRCA1 breast cancer 1, early onset 2.88009
H2AFX H2A histone family, member X 1.69993
BTG2 BTG family, member 2 1.63832
TP53 tumor protein p53 1.61014
PSRC1 proline/serine-rich coiled-coil 1 1.56337
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.5555
MAPK1 mitogen-activated protein kinase 1 1.54451
PHLDA3 pleckstrin homology-like domain, family A, member 3 1.54086
BORA bora, aurora kinase A activator 1.52566
PARP1 poly (ADP-ribose) polymerase 1 1.51305
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.4966
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.48556
BCL2L1 BCL2-like 1 1.48505
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.48068
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 1.46807
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 1.45273
GDF15 growth differentiation factor 15 1.44544
MAPK3 mitogen-activated protein kinase 3 1.4449
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.43239
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 1.42535
RUNX2 runt-related transcription factor 2 1.41119
LDHA lactate dehydrogenase A 1.41091
TRADD TNFRSF1A-associated via death domain 1.4098
BAX BCL2-associated X protein 1.40953
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 1.40677
TNF tumor necrosis factor 1.39591
TXNRD1 thioredoxin reductase 1 1.39282
DNMT1 DNA (cytosine-5-)-methyltransferase 1 1.38946
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.37958
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.37103
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.36533
CHEK1 checkpoint kinase 1 1.36161
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.35906
SOD1 superoxide dismutase 1, soluble 1.35849
FOS FBJ murine osteosarcoma viral oncogene homolog 1.35647
SESN1 sestrin 1 1.35618
COL1A2 collagen, type I, alpha 2 1.34459
GADD45A growth arrest and DNA-damage-inducible, alpha 1.33966
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.33731
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.33257
CKS2 CDC28 protein kinase regulatory subunit 2 1.3311
CCNB1 cyclin B1 1.32667
PCNA proliferating cell nuclear antigen 1.30881
CKB creatine kinase, brain 1.30269
CDC6 cell division cycle 6 1.29657
RRAS related RAS viral (r-ras) oncogene homolog 1.29194
CCNE2 cyclin E2 1.27845
CCND1 cyclin D1 1.27751
SOD2 superoxide dismutase 2, mitochondrial 1.27347
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.27039
MKNK2 MAP kinase interacting serine/threonine kinase 2 1.26947
DDB2 damage-specific DNA binding protein 2, 48kDa 1.26267
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 1.25619
CCNA2 cyclin A2 1.25463
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 1.254
BLM Bloom syndrome, RecQ helicase-like 1.25307
TP53INP1 tumor protein p53 inducible nuclear protein 1 1.25276
BCL2 B-cell CLL/lymphoma 2 1.24874
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 1.24718
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.24465
CCNG1 cyclin G1 1.2368
GADD45B growth arrest and DNA-damage-inducible, beta 1.2368
RRM2 ribonucleotide reductase M2 1.23074
SRXN1 sulfiredoxin 1 1.22948
AFP alpha-fetoprotein 1.22501
ATR ATR serine/threonine kinase 1.22016
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 1.21141
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.20881
TFF1 trefoil factor 1 1.20848
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.20196
IL6 interleukin 6 1.20163
NFE2L2 nuclear factor, erythroid 2-like 2 1.20097
UBL3 ubiquitin-like 3 1.19014
NRIP1 nuclear receptor interacting protein 1 1.1862
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.18521
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.18391
PRC1 protein regulator of cytokinesis 1 1.18391
TICAM1 toll-like receptor adaptor molecule 1 1.18359
COL1A1 collagen, type I, alpha 1 1.18093
VCAM1 vascular cell adhesion molecule 1 1.17926
MSH6 mutS homolog 6 1.17893
NQO1 NAD(P)H dehydrogenase, quinone 1 1.17893
KDM5A lysine (K)-specific demethylase 5A 1.17728
HMOX1 heme oxygenase 1 1.17662
RRM1 ribonucleotide reductase M1 1.17629
RB1 retinoblastoma 1 1.17563
TYMS thymidylate synthetase 1.17431
STC2 stanniocalcin 2 1.16533
ESR2 estrogen receptor 2 (ER beta) 1.1607
CBS cystathionine-beta-synthase 1.1607
FAS Fas cell surface death receptor 1.15627
PRODH2 proline dehydrogenase (oxidase) 2 1.15526
LDHB lactate dehydrogenase B 1.15425
SESN2 sestrin 2 1.15256
CDKN2A cyclin-dependent kinase inhibitor 2A 1.14954
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.14919
PMP22 peripheral myelin protein 22 1.1485
JUN jun proto-oncogene 1.14816
BRCA2 breast cancer 2, early onset 1.14404
PTEN phosphatase and tensin homolog 1.14302
TOP2A topoisomerase (DNA) II alpha 170kDa 1.14302
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 1.13484
DDIT3 DNA-damage-inducible transcript 3 1.13484
UNG uracil-DNA glycosylase 1.13415
PLK2 polo-like kinase 2 1.13041
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 1.12872
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.12668
EGFR epidermal growth factor receptor 1.12288
TUBB4B tubulin, beta 4B class IVb 1.12288
MPZL1 myelin protein zero-like 1 1.11877
UBE2C ubiquitin-conjugating enzyme E2C 1.11606
LMNA lamin A/C 1.11431
FAM46A family with sequence similarity 46, member A 1.11396
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 1.10907
CCNE1 cyclin E1 1.10562
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 1.10388
TK1 thymidine kinase 1, soluble 1.10388
TIPIN TIMELESS interacting protein 1.10211
ANGPTL2 angiopoietin-like 2 1.10175
AEN apoptosis enhancing nuclease 1.09471
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 1.09262
IGFBP5 insulin-like growth factor binding protein 5 1.09226
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.09047
HIST1H4C histone cluster 1, H4c 1.08726
LGALS3 lectin, galactoside-binding, soluble, 3 1.08584
COL2A1 collagen, type II, alpha 1 1.08442
VAT1 vesicle amine transport 1 1.08301
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 1.07947
FANCG Fanconi anemia, complementation group G 1.07911
RGS2 regulator of G-protein signaling 2 1.07804
GSTP1 glutathione S-transferase pi 1 1.07589
RAD51 RAD51 recombinase 1.07482
NET1 neuroepithelial cell transforming 1 1.07234
MET MET proto-oncogene, receptor tyrosine kinase 1.07199
BBC3 BCL2 binding component 3 1.07093
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.07093
CDK1 cyclin-dependent kinase 1 1.06917
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 1.06844
TGFA transforming growth factor, alpha 1.06588
DCT dopachrome tautomerase 1.06552
HPRT1 hypoxanthine phosphoribosyltransferase 1 1.0608
CHAF1B chromatin assembly factor 1, subunit B (p60) 1.059
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 1.0561
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 1.05461
ERCC5 excision repair cross-complementation group 5 1.05015
COL3A1 collagen, type III, alpha 1 1.05015
PCSK5 proprotein convertase subtilisin/kexin type 5 1.04978
CHEK2 checkpoint kinase 2 1.04941
ANG angiogenin, ribonuclease, RNase A family, 5 1.04941
MYLIP myosin regulatory light chain interacting protein 1.04684
PNRC1 proline-rich nuclear receptor coactivator 1 1.04611
SMC2 structural maintenance of chromosomes 2 1.04314
CAT catalase 1.04088
H1F0 H1 histone family, member 0 1.04088
PA2G4 proliferation-associated 2G4, 38kDa 1.04051
PLSCR1 phospholipid scramblase 1 1.03976
BTG3 BTG family, member 3 1.03827
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 1.03715
PPARG peroxisome proliferator-activated receptor gamma 1.03641
E2F1 E2F transcription factor 1 1.03419
TMEM156 transmembrane protein 156 1.03308
TRIB3 tribbles pseudokinase 3 1.03271
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.03197
TGFB1 transforming growth factor, beta 1 1.03159
KRAS Kirsten rat sarcoma viral oncogene homolog 1.03159
TMEM126A transmembrane protein 126A 1.03159
SPAG5 sperm associated antigen 5 1.03122
MGMT O-6-methylguanine-DNA methyltransferase 1.03046
FBXO5 F-box protein 5 1.02971
ANLN anillin, actin binding protein 1.02858
CD63 CD63 molecule 1.02858
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 1.02858
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 1.02634
SMOX spermine oxidase 1.02336
MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 1.02299
CD44 CD44 molecule (Indian blood group) 1.02262
IGF1R insulin-like growth factor 1 receptor 1.02188
S100P S100 calcium binding protein P 1.02188
DDIT4 DNA-damage-inducible transcript 4 1.02151
TEK TEK tyrosine kinase, endothelial 1.01814
ZMAT3 zinc finger, matrin-type 3 1.01739
SQSTM1 sequestosome 1 1.01625
CYCS cytochrome c, somatic 1.01512
RFC3 replication factor C (activator 1) 3, 38kDa 1.01324
CXCL12 chemokine (C-X-C motif) ligand 12 1.01286
APP amyloid beta (A4) precursor protein 1.01062
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 1.01025