Chorea Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A movement disease characterized by brief, semi-directed, irregular movements that not repetitive or rhythmic, but appear to flow from one muscle to the next. (Human Disease Ontology, DOID_12859)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D002819
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Genes

125 genes/proteins associated with the disease Chorea from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
NKX2-1 NK2 homeobox 1 2.88009
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 2.88009
PRL prolactin 2.40654
DRD2 dopamine receptor D2 2.23534
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 2.16225
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 2.13782
FOS FBJ murine osteosarcoma viral oncogene homolog 2.0739
BDNF brain-derived neurotrophic factor 2.03078
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.02905
DRD1 dopamine receptor D1 2.01186
CAT catalase 1.96086
BCL2 B-cell CLL/lymphoma 2 1.89845
BAX BCL2-associated X protein 1.89763
TH tyrosine hydroxylase 1.88671
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.82831
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.80548
MAPK1 mitogen-activated protein kinase 1 1.78587
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.78207
PENK proenkephalin 1.73858
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.7185
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.69082
MAPK3 mitogen-activated protein kinase 3 1.67483
ARC activity-regulated cytoskeleton-associated protein 1.66835
EGR1 early growth response 1 1.6621
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 1.64797
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.64235
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.62357
HRH1 histamine receptor H1 1.60035
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.56117
TAC1 tachykinin, precursor 1 1.5555
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.5382
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.53699
DRD3 dopamine receptor D3 1.49508
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.46858
JUN jun proto-oncogene 1.44572
CDK5 cyclin-dependent kinase 5 1.43946
TNF tumor necrosis factor 1.43837
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.42616
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 1.42508
CRH corticotropin releasing hormone 1.4076
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.40092
INS insulin 1.39869
NPY neuropeptide Y 1.39366
GRIA2 glutamate receptor, ionotropic, AMPA 2 1.39338
OPRM1 opioid receptor, mu 1 1.39198
SOD1 superoxide dismutase 1, soluble 1.381
GSTP1 glutathione S-transferase pi 1 1.37246
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 1.36619
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 1.36361
NOS2 nitric oxide synthase 2, inducible 1.35705
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.35647
RGS4 regulator of G-protein signaling 4 1.32667
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 1.31716
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.31416
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 1.30208
HMOX1 heme oxygenase 1 1.29103
INHBE inhibin, beta E 1.29041
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.28088
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 1.27626
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.27286
GRM1 glutamate receptor, metabotropic 1 1.27224
DRD4 dopamine receptor D4 1.26825
DUSP1 dual specificity phosphatase 1 1.25369
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.24496
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.23552
MAPK8 mitogen-activated protein kinase 8 1.22853
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 1.22664
IFNG interferon, gamma 1.22274
IL6 interleukin 6 1.22274
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 1.21337
AVP arginine vasopressin 1.21173
NCAN neurocan 1.20427
RGS2 regulator of G-protein signaling 2 1.18751
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 1.18751
PRKCE protein kinase C, epsilon 1.18554
FSHB follicle stimulating hormone, beta polypeptide 1.18059
CCND1 cyclin D1 1.17034
JUNB jun B proto-oncogene 1.17034
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.1607
FOSL2 FOS-like antigen 2 1.16001
CALM2 calmodulin 2 (phosphorylase kinase, delta) 1.1485
PDYN prodynorphin 1.14336
CNR1 cannabinoid receptor 1 (brain) 1.13621
ACHE acetylcholinesterase (Yt blood group) 1.13518
NUPR1 nuclear protein, transcriptional regulator, 1 1.13449
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 1.13007
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.12185
LHB luteinizing hormone beta polypeptide 1.11877
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.11741
PDE4B phosphodiesterase 4B, cAMP-specific 1.11707
TP53 tumor protein p53 1.11639
ADORA2A adenosine A2a receptor 1.11466
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 1.10388
C10ORF10 chromosome 10 open reading frame 10 1.10388
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.10211
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.09998
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 1.09646
CCL2 chemokine (C-C motif) ligand 2 1.09332
TAGLN transgelin 1.08619
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.08231
HOMER1 homer scaffolding protein 1 1.0784
RELN reelin 1.0784
FNDC4 fibronectin type III domain containing 4 1.07804
IL10 interleukin 10 1.07732
AANAT aralkylamine N-acetyltransferase 1.07589
IL2 interleukin 2 1.07553
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.07447
COMT catechol-O-methyltransferase 1.07057
SOD2 superoxide dismutase 2, mitochondrial 1.06698
CREB1 cAMP responsive element binding protein 1 1.06698
GRIK2 glutamate receptor, ionotropic, kainate 2 1.06552
MPO myeloperoxidase 1.06261
RGS9 regulator of G-protein signaling 9 1.06008
EGR3 early growth response 3 1.05828
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.05126
GSK3B glycogen synthase kinase 3 beta 1.04757
MAOB monoamine oxidase B 1.04684
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.04501
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 1.04389
IL18 interleukin 18 1.04051
FABP1 fatty acid binding protein 1, liver 1.03084
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 1.02708
GAL galanin/GMAP prepropeptide 1.02708
NTS neurotensin 1.0241
NTF3 neurotrophin 3 1.0189