Cholesterol biosynthesis Gene Set

Dataset Reactome Pathways
Category structural or functional annotations
Type pathway
Description The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. (Gene Ontology, GO_0006695)
External Link http://www.reactome.org/PathwayBrowser/#/R-HSA-191273
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Genes

22 proteins participating in the Cholesterol biosynthesis pathway from the Reactome Pathways dataset.

Symbol Name
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GGPS1 geranylgeranyl diphosphate synthase 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IDI1 isopentenyl-diphosphate delta isomerase 1
IDI2 isopentenyl-diphosphate delta isomerase 2
LBR lamin B receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MSMO1 methylsterol monooxygenase 1
MVD mevalonate (diphospho) decarboxylase
MVK mevalonate kinase
NSDHL NAD(P) dependent steroid dehydrogenase-like
PMVK phosphomevalonate kinase
SC5D sterol-C5-desaturase
SQLE squalene epoxidase
TM7SF2 transmembrane 7 superfamily member 2