Cholesterol, HDL Gene Set

Dataset dbGAP Gene-Trait Associations
Category disease or phenotype associations
Type trait
Description disease cluster belonging to disease group metabolic (Genetic Association Database)
Similar Terms
Downloads & Tools

Genes

357 genes associated with the trait Cholesterol, HDL in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

Symbol Name Standardized Value
CETP cholesteryl ester transfer protein, plasma 2.195
ZPR1 ZPR1 zinc finger 1.88456
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 1.77521
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1.72657
PSKH1 protein serine kinase H1 1.72047
LIPC lipase, hepatic 1.71516
APOB apolipoprotein B 1.69034
DEFA3 defensin, alpha 3, neutrophil-specific 1.52295
LPL lipoprotein lipase 1.48786
FADS1 fatty acid desaturase 1 1.47689
AFF2 AF4/FMR2 family, member 2 1.47465
APOC1 apolipoprotein C-I 1.43786
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 1.43786
ATP10B ATPase, class V, type 10B 1.37992
KLF3-AS1 KLF3 antisense RNA 1 1.36094
GPC5 glypican 5 1.35159
F2 coagulation factor II (thrombin) 1.33123
NUTF2 nuclear transport factor 2 1.23835
HNF4A hepatocyte nuclear factor 4, alpha 1.23281
FAM117B family with sequence similarity 117, member B 1.22788
PTPRM protein tyrosine phosphatase, receptor type, M 1.19864
NRG3 neuregulin 3 1.19573
LINGO2 leucine rich repeat and Ig domain containing 2 1.19557
CCDC109B coiled-coil domain containing 109B 1.18716
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 1.18594
STARD3 StAR-related lipid transfer (START) domain containing 3 1.15755
ADGRL2 adhesion G protein-coupled receptor L2 1.15568
C15ORF41 chromosome 15 open reading frame 41 1.15116
TTC39B tetratricopeptide repeat domain 39B 1.12979
DLEU7 deleted in lymphocytic leukemia, 7 1.11546
CRAT carnitine O-acetyltransferase 1.11091
ZBTB20 zinc finger and BTB domain containing 20 1.10588
PDE4B phosphodiesterase 4B, cAMP-specific 1.06326
NXPH1 neurexophilin 1 1.02321
MYO16 myosin XVI 1.00147
CMIP c-Maf inducing protein 0.995026
DPP6 dipeptidyl-peptidase 6 0.980748
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.973098
ITPK1 inositol-tetrakisphosphate 1-kinase 0.963177
TRPS1 trichorhinophalangeal syndrome I 0.960111
OR4A46P olfactory receptor, family 4, subfamily A, member 46 pseudogene 0.960111
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.955241
FOXO3 forkhead box O3 0.952171
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0.951076
GRID2 glutamate receptor, ionotropic, delta 2 0.950865
MYO10 myosin X 0.949973
KCTD10 potassium channel tetramerization domain containing 10 0.944178
FBN1 fibrillin 1 0.941065
SORCS1 sortilin-related VPS10 domain containing receptor 1 0.93998
ANO4 anoctamin 4 0.932753
DNAH11 dynein, axonemal, heavy chain 11 0.928533
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 0.923038
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 0.922056
TRA T cell receptor alpha locus 0.921222
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 0.909595
COBLL1 cordon-bleu WH2 repeat protein-like 1 0.907793
ZNF664 zinc finger protein 664 0.907793
CALCR calcitonin receptor 0.897435
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) 0.897125
TMOD2 tropomodulin 2 (neuronal) 0.894523
TMOD3 tropomodulin 3 (ubiquitous) 0.890141
CERS6 ceramide synthase 6 0.870949
TBL2 transducin (beta)-like 2 0.862644
MICU2 mitochondrial calcium uptake 2 0.862309
MTUS2 microtubule associated tumor suppressor candidate 2 0.845094
DOCK6 dedicator of cytokinesis 6 0.820059
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.813229
PCIF1 PDX1 C-terminal inhibiting factor 1 0.807263
PTPRD protein tyrosine phosphatase, receptor type, D 0.804849
PGS1 phosphatidylglycerophosphate synthase 1 0.796965
CFAP69 cilia and flagella associated protein 69 0.784868
RFX8 RFX family member 8, lacking RFX DNA binding domain 0.779781
SBNO1 strawberry notch homolog 1 (Drosophila) 0.774665
GTDC1 glycosyltransferase-like domain containing 1 0.770777
ZNF568 zinc finger protein 568 0.770284
RAB11B RAB11B, member RAS oncogene family 0.763999
UBE2L3 ubiquitin-conjugating enzyme E2L 3 0.763999
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.757676
TENM2 teneurin transmembrane protein 2 0.756238
SGCZ sarcoglycan, zeta 0.747109
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.741903
HEATR1 HEAT repeat containing 1 0.741555
WWC3 WWC family member 3 0.741027
CMYA5 cardiomyopathy associated 5 0.740256
PLS3 plastin 3 0.739586
TRPM3 transient receptor potential cation channel, subfamily M, member 3 0.737128
DMD dystrophin 0.733531
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.730577
AFF3 AF4/FMR2 family, member 3 0.727128
MOB3B MOB kinase activator 3B 0.718495
LAMA2 laminin, alpha 2 0.717367
ANGPTL4 angiopoietin-like 4 0.711358
DPEP3 dipeptidase 3 0.711358
NR1H3 nuclear receptor subfamily 1, group H, member 3 0.696869
BORA bora, aurora kinase A activator 0.693299
EPHA6 EPH receptor A6 0.69067
USH2A Usher syndrome 2A (autosomal recessive, mild) 0.689888
TMEM163 transmembrane protein 163 0.688256
ARL15 ADP-ribosylation factor-like 15 0.685324
DSCAML1 Down syndrome cell adhesion molecule like 1 0.678427
RBMS3 RNA binding motif, single stranded interacting protein 3 0.675171
DTHD1 death domain containing 1 0.6682
MTUS1 microtubule associated tumor suppressor 1 0.664277
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.654926
WWOX WW domain containing oxidoreductase 0.651206
GNA12 guanine nucleotide binding protein (G protein) alpha 12 0.649832
SYT1 synaptotagmin I 0.649654
THSD7B thrombospondin, type I, domain containing 7B 0.649198
KRTAP3-2 keratin associated protein 3-2 0.648607
DPEP2 dipeptidase 2 0.64828
EIF3H eukaryotic translation initiation factor 3, subunit H 0.636407
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.631835
CCNY cyclin Y 0.629526
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.627875
CTIF CBP80/20-dependent translation initiation factor 0.62704
MEGF10 multiple EGF-like-domains 10 0.626502
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.616091
IL20RA interleukin 20 receptor, alpha 0.614644
GRIK2 glutamate receptor, ionotropic, kainate 2 0.609968
TTC21B tetratricopeptide repeat domain 21B 0.603726
MKL2 MKL/myocardin-like 2 0.598347
KLHL1 kelch-like family member 1 0.595426
MID1 midline 1 0.588887
PDE4D phosphodiesterase 4D, cAMP-specific 0.588511
SCFD1 sec1 family domain containing 1 0.587143
SHROOM4 shroom family member 4 0.580092
CNTN4 contactin 4 0.571559
APP amyloid beta (A4) precursor protein 0.568807
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 0.567219
FADS2 fatty acid desaturase 2 0.567219
ATF6 activating transcription factor 6 0.567206
CLEC1B C-type lectin domain family 1, member B 0.557236
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.555546
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.546288
PAWR PRKC, apoptosis, WT1, regulator 0.544055
OSTM1 osteopetrosis associated transmembrane protein 1 0.543586
DIAPH3 diaphanous-related formin 3 0.540686
TMEM258 transmembrane protein 258 0.539181
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.53419
RFX7 regulatory factor X, 7 0.510301
UNC5D unc-5 homolog D (C. elegans) 0.510066
SULT1D1P sulfotransferase family, cytosolic, 1D, member 1, pseudogene 0.506573
BTBD1 BTB (POZ) domain containing 1 0.505589
CFAP54 cilia and flagella associated 54 0.498713
SS18 synovial sarcoma translocation, chromosome 18 0.495298
KLHL13 kelch-like family member 13 0.491193
ZYG11B zyg-11 family member B, cell cycle regulator 0.486355
WDR81 WD repeat domain 81 0.481305
ZCCHC6 zinc finger, CCHC domain containing 6 0.480557
PARD3B par-3 family cell polarity regulator beta 0.480297
SSFA2 sperm specific antigen 2 0.478842
FSTL5 follistatin-like 5 0.477544
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) 0.476611
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.465766
SAMD4A sterile alpha motif domain containing 4A 0.462129
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.460248
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 0.454584
MCTP2 multiple C2 domains, transmembrane 2 0.453344
PDE10A phosphodiesterase 10A 0.44078
CLEC16A C-type lectin domain family 16, member A 0.422773
PCDH15 protocadherin-related 15 0.414244
ZNF236 zinc finger protein 236 0.41171
NUBPL nucleotide binding protein-like 0.410153
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.406869
PID1 phosphotyrosine interaction domain containing 1 0.405259
CCDC102B coiled-coil domain containing 102B 0.390523
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.388741
RNF121 ring finger protein 121 0.387607
AQP9 aquaporin 9 0.387353
NCOA7 nuclear receptor coactivator 7 0.379816
CSMD1 CUB and Sushi multiple domains 1 0.376428
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.375316
KIF26B kinesin family member 26B 0.367915
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 0.356676
MTRNR2L6 MT-RNR2-like 6 0.355822
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 0.355654
PAQR5 progestin and adipoQ receptor family member V 0.354325
ZNF780B zinc finger protein 780B 0.343737
EDN3 endothelin 3 0.341937
LPIN2 lipin 2 0.341507
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 0.33862
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.33862
ATP8B4 ATPase, class I, type 8B, member 4 0.336285
SH3RF1 SH3 domain containing ring finger 1 0.328057
KYNU kynureninase 0.327111
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 0.323533
SLC7A14 solute carrier family 7, member 14 0.32177
POTEA POTE ankyrin domain family, member A 0.319584
WDR3 WD repeat domain 3 0.317803
SPAG17 sperm associated antigen 17 0.317803
C20ORF196 chromosome 20 open reading frame 196 0.314625
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.314016
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 0.308572
CLNK cytokine-dependent hematopoietic cell linker 0.304672
PDE1A phosphodiesterase 1A, calmodulin-dependent 0.292811
PEBP4 phosphatidylethanolamine-binding protein 4 0.287508
TBR1 T-box, brain, 1 0.285313
ZNF492 zinc finger protein 492 0.284091
ZNF257 zinc finger protein 257 0.284091
COL27A1 collagen, type XXVII, alpha 1 0.282049
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 0.276957
DLC1 DLC1 Rho GTPase activating protein 0.272181
FBXL17 F-box and leucine-rich repeat protein 17 0.258427
TRAPPC8 trafficking protein particle complex 8 0.255773
HNMT histamine N-methyltransferase 0.25266
XKR9 XK, Kell blood group complex subunit-related family, member 9 0.240181
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 0.240181
PCSK7 proprotein convertase subtilisin/kexin type 7 0.238651
EPHA3 EPH receptor A3 0.235075
SCN3B sodium channel, voltage gated, type III beta subunit 0.234698
NEGR1 neuronal growth regulator 1 0.233562
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.231969
FAM184A family with sequence similarity 184, member A 0.228621
PARK2 parkin RBR E3 ubiquitin protein ligase 0.22688
SNX25 sorting nexin 25 0.226013
RHOF ras homolog family member F (in filopodia) 0.223863
TMEM120B transmembrane protein 120B 0.223863
USP34 ubiquitin specific peptidase 34 0.223854
ACAT2 acetyl-CoA acetyltransferase 2 0.219576
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.215348
MAML2 mastermind-like 2 (Drosophila) 0.212835
INVS inversin 0.207186
ERBB4 erb-b2 receptor tyrosine kinase 4 0.204026
RNF157 ring finger protein 157 0.199365
KLHL29 kelch-like family member 29 0.198893
TMEM106B transmembrane protein 106B 0.197493
CLCN3 chloride channel, voltage-sensitive 3 0.196047
DNAH5 dynein, axonemal, heavy chain 5 0.189587
CHI3L2 chitinase 3-like 2 0.186386
NINL ninein-like 0.185627
NRXN1 neurexin 1 0.184116
GEMIN5 gem (nuclear organelle) associated protein 5 0.184116
DUOX1 dual oxidase 1 0.182776
PALLD palladin, cytoskeletal associated protein 0.182762
SLIT2 slit homolog 2 (Drosophila) 0.182711
KDSR 3-ketodihydrosphingosine reductase 0.180402
AUNIP aurora kinase A and ninein interacting protein 0.176429
POU1F1 POU class 1 homeobox 1 0.175799
GRID1 glutamate receptor, ionotropic, delta 1 0.173152
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7 0.171107
ZNF57 zinc finger protein 57 0.169502
CLUL1 clusterin-like 1 (retinal) 0.167555
ATRN attractin 0.166547
CASS4 Cas scaffolding protein family member 4 0.165958
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 0.16254
RORA RAR-related orphan receptor A 0.157593
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.157159
KLK14 kallikrein-related peptidase 14 0.153684
DLG2 discs, large homolog 2 (Drosophila) 0.153375
FLT1 fms-related tyrosine kinase 1 0.152188
HCRTR2 hypocretin (orexin) receptor 2 0.151647
NPAS3 neuronal PAS domain protein 3 0.15136
PLSCR4 phospholipid scramblase 4 0.151107
PCSK2 proprotein convertase subtilisin/kexin type 2 0.150885
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.150568
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.150568
RTN4 reticulon 4 0.147349
C1ORF110 chromosome 1 open reading frame 110 0.14642
PAPD4 PAP associated domain containing 4 0.146282
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 0.145218
UTP15 UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae) 0.145218
MSRA methionine sulfoxide reductase A 0.144124
MTFR1L mitochondrial fission regulator 1-like 0.143297
TEX10 testis expressed 10 0.142098
PTCHD4 patched domain containing 4 0.141518
MED12L mediator complex subunit 12-like 0.139944
P2RY12 purinergic receptor P2Y, G-protein coupled, 12 0.139944
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.137336
MBP myelin basic protein 0.13423
RMDN2 regulator of microtubule dynamics 2 0.133383
KCNH5 potassium channel, voltage gated eag related subfamily H, member 5 0.1332
KDM4D lysine (K)-specific demethylase 4D 0.132173
MROH7 maestro heat-like repeat family member 7 0.13115
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 0.129111
IQSEC3 IQ motif and Sec7 domain 3 0.129111
ECT2L epithelial cell transforming 2 like 0.128991
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.128603
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.125475
PABPC1L poly(A) binding protein, cytoplasmic 1-like 0.124639
EPHA7 EPH receptor A7 0.124063
WDSUB1 WD repeat, sterile alpha motif and U-box domain containing 1 0.121529
MECOM MDS1 and EVI1 complex locus 0.121483
GPC6 glypican 6 0.119477
LOXL2 lysyl oxidase-like 2 0.118107
NSUN4 NOP2/Sun domain family, member 4 0.115408
LAMP3 lysosomal-associated membrane protein 3 0.114903
RAB3C RAB3C, member RAS oncogene family 0.114555
C7 complement component 7 0.114398
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.110852
LRRC16A leucine rich repeat containing 16A 0.109388
CHCHD6 coiled-coil-helix-coiled-coil-helix domain containing 6 0.109388
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.108395
PLCB4 phospholipase C, beta 4 0.106416
CA12 carbonic anhydrase XII 0.104855
TBCA tubulin folding cofactor A 0.104447
LHFP lipoma HMGIC fusion partner 0.103957
EXOC6 exocyst complex component 6 0.103827
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 0.101028
XPO1 exportin 1 0.099572
PCDH9 protocadherin 9 0.099279
TGFBR3 transforming growth factor, beta receptor III 0.099089
ASIC2 acid sensing (proton gated) ion channel 2 0.098803
GPR158 G protein-coupled receptor 158 0.098605
TEP1 telomerase-associated protein 1 0.098605
COMMD1 copper metabolism (Murr1) domain containing 1 0.098605
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 0.098123
INTS12 integrator complex subunit 12 0.097159
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 0.094982
FMN2 formin 2 0.094285
OMA1 OMA1 zinc metallopeptidase 0.094285
RXRG retinoid X receptor, gamma 0.092482
SORCS3 sortilin-related VPS10 domain containing receptor 3 0.091464
CWC15 CWC15 spliceosome-associated protein 0.089852
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.086808
RASGRP4 RAS guanyl releasing protein 4 0.086642
TMEM2 transmembrane protein 2 0.085512
ALK anaplastic lymphoma receptor tyrosine kinase 0.083872
COL19A1 collagen, type XIX, alpha 1 0.082353
GINS1 GINS complex subunit 1 (Psf1 homolog) 0.082205
LSAMP limbic system-associated membrane protein 0.08199
MYO1D myosin ID 0.08165
SPRN shadow of prion protein homolog (zebrafish) 0.079099
NUTM1 NUT midline carcinoma, family member 1 0.078676
ERP44 endoplasmic reticulum protein 44 0.078019
KIRREL3 kin of IRRE like 3 (Drosophila) 0.07634
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 0.075726
HPCAL1 hippocalcin-like 1 0.074523
ARHGAP25 Rho GTPase activating protein 25 0.074097
ROR1 receptor tyrosine kinase-like orphan receptor 1 0.073635
ARHGAP42 Rho GTPase activating protein 42 0.073635
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.072603
HOPX HOP homeobox 0.07246
TACC2 transforming, acidic coiled-coil containing protein 2 0.07197
NPHP4 nephronophthisis 4 0.070314
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 0.069901
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.068318
HTT huntingtin 0.068238
CSMD3 CUB and Sushi multiple domains 3 0.066457
RUNX2 runt-related transcription factor 2 0.065651
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.065651
CDC123 cell division cycle 123 0.065319
NUP93 nucleoporin 93kDa 0.065107
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.064739
ATXN7L1 ataxin 7-like 1 0.064656
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 0.063995
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 0.063664
RMST rhabdomyosarcoma 2 associated transcript (non-protein coding) 0.063335
SIK3 SIK family kinase 3 0.063081
ATP11AUN ATP11A upstream neighbor 0.063005
KIAA0355 KIAA0355 0.061106
GRM7 glutamate receptor, metabotropic 7 0.059075
EGFR epidermal growth factor receptor 0.058962
TBL1X transducin (beta)-like 1X-linked 0.05875
GPR139 G protein-coupled receptor 139 0.058586
HHAT hedgehog acyltransferase 0.058395
IPO8 importin 8 0.058331
NTNG1 netrin G1 0.0581