Cellular Senescence Gene Set

Dataset Reactome Pathways
Category structural or functional annotations
Type pathway
Description A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest. (Gene Ontology, GO_0090398)
External Link http://www.reactome.org/PathwayBrowser/#/R-HSA-2559583
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Genes

158 proteins participating in the Cellular Senescence pathway from the Reactome Pathways dataset.

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
AGO1 argonaute RISC catalytic component 1
AGO3 argonaute RISC catalytic component 3
AGO4 argonaute RISC catalytic component 4
ANAPC1 anaphase promoting complex subunit 1
ANAPC10 anaphase promoting complex subunit 10
ANAPC11 anaphase promoting complex subunit 11
ANAPC2 anaphase promoting complex subunit 2
ANAPC4 anaphase promoting complex subunit 4
ANAPC5 anaphase promoting complex subunit 5
ANAPC7 anaphase promoting complex subunit 7
ASF1A anti-silencing function 1A histone chaperone
ATM ATM serine/threonine kinase
BMI1 BMI1 proto-oncogene, polycomb ring finger
CABIN1 calcineurin binding protein 1
CBX2 chromobox homolog 2
CBX4 chromobox homolog 4
CBX6 chromobox homolog 6
CBX8 chromobox homolog 8
CCNA1 cyclin A1
CCNA2 cyclin A2
CCNE1 cyclin E1
CCNE2 cyclin E2
CDC16 cell division cycle 16
CDC23 cell division cycle 23
CDC26 cell division cycle 26
CDC27 cell division cycle 27
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CXCL8 chemokine (C-X-C motif) ligand 8
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
E2F3 E2F transcription factor 3
EED embryonic ectoderm development
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EHMT2 euchromatic histone-lysine N-methyltransferase 2
EP400 E1A binding protein p400
ERF Ets2 repressor factor
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FOS FBJ murine osteosarcoma viral oncogene homolog
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
H1F0 H1 histone family, member 0
H2AFB1 H2A histone family, member B1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
H2BFS H2B histone family, member S (pseudogene)
H3F3A H3 histone, family 3A
HIRA histone cell cycle regulator
HIST1H1A histone cluster 1, H1a
HIST1H1B histone cluster 1, H1b
HIST1H1C histone cluster 1, H1c
HIST1H1D histone cluster 1, H1d
HIST1H1E histone cluster 1, H1e
HIST1H2AB histone cluster 1, H2ab
HIST1H2AC histone cluster 1, H2ac
HIST1H2AD histone cluster 1, H2ad
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BA histone cluster 1, H2ba
HIST1H2BB histone cluster 1, H2bb
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BH histone cluster 1, H2bh
HIST1H2BJ histone cluster 1, H2bj
HIST1H2BK histone cluster 1, H2bk
HIST1H2BL histone cluster 1, H2bl
HIST1H2BM histone cluster 1, H2bm
HIST1H2BN histone cluster 1, H2bn
HIST1H2BO histone cluster 1, H2bo
HIST1H3A histone cluster 1, H3a
HIST1H4A histone cluster 1, H4a
HIST2H2AA3 histone cluster 2, H2aa3
HIST2H2AC histone cluster 2, H2ac
HIST2H2BE histone cluster 2, H2be
HIST2H3A histone cluster 2, H3a
HIST3H2BB histone cluster 3, H2bb
HIST3H3 histone cluster 3, H3
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFNB1 interferon, beta 1, fibroblast
IGFBP7 insulin-like growth factor binding protein 7
IL1A interleukin 1, alpha
IL6 interleukin 6
JUN jun proto-oncogene
KDM6B lysine (K)-specific demethylase 6B
LMNB1 lamin B1
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K6 mitogen-activated protein kinase kinase 6
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK11 mitogen-activated protein kinase 11
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MINK1 misshapen-like kinase 1
MIR24-1 microRNA 24-1
MIR24-2 microRNA 24-2
MOV10 Mov10 RISC complex RNA helicase
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
NBN nibrin
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
PHC1 polyhomeotic homolog 1 (Drosophila)
PHC2 polyhomeotic homolog 2 (Drosophila)
PHC3 polyhomeotic homolog 3 (Drosophila)
POT1 protection of telomeres 1
RAD50 RAD50 homolog (S. cerevisiae)
RB1 retinoblastoma 1
RBBP4 retinoblastoma binding protein 4
RBBP7 retinoblastoma binding protein 7
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RING1 ring finger protein 1
RNF2 ring finger protein 2
RPS27A ribosomal protein S27a
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SP1 Sp1 transcription factor
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TERF2 telomeric repeat binding factor 2
TERF2IP telomeric repeat binding factor 2, interacting protein
TFDP1 transcription factor Dp-1
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TNIK TRAF2 and NCK interacting kinase
TNRC6A trinucleotide repeat containing 6A
TNRC6B trinucleotide repeat containing 6B
TNRC6C trinucleotide repeat containing 6C
TP53 tumor protein p53
TXN thioredoxin
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBE2C ubiquitin-conjugating enzyme E2C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBN1 ubinuclein 1