COPD - Chronic obstructive pulmonary disease_Bronchial epithelium_GSE3320 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Diseases
Category transcriptomics
Type disease perturbation
Description disease perturbation identified as [disease]_[tissue]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE3320
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Genes

600 genes differentially expressed during COPD - Chronic obstructive pulmonary disease_Bronchial epithelium_GSE3320 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.

increased expression

Symbol Name Standardized Value
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 3.93374
FECH ferrochelatase 3.53191
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 3.37794
TALDO1 transaldolase 1 3.32552
NQO1 NAD(P)H dehydrogenase, quinone 1 3.1852
MBD4 methyl-CpG binding domain protein 4 3.12048
ACE2 angiotensin I converting enzyme 2 2.90681
GALNS galactosamine (N-acetyl)-6-sulfatase 2.90162
NAA60 N(alpha)-acetyltransferase 60, NatF catalytic subunit 2.89049
CSNK2A1 casein kinase 2, alpha 1 polypeptide 2.88351
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa 2.78796
GPX2 glutathione peroxidase 2 2.78144
NOLC1 nucleolar and coiled-body phosphoprotein 1 2.70188
SLC39A11 solute carrier family 39, member 11 2.69339
AKR1C2 aldo-keto reductase family 1, member C2 2.6049
TRIM21 tripartite motif containing 21 2.54722
FMOD fibromodulin 2.47484
SRRM1 serine/arginine repetitive matrix 1 2.46482
BRD4 bromodomain containing 4 2.44615
C1RL complement component 1, r subcomponent-like 2.4437
PHTF2 putative homeodomain transcription factor 2 2.4203
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4 2.40372
FTH1 ferritin, heavy polypeptide 1 2.3998
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2.36347
MPZL1 myelin protein zero-like 1 2.35371
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head) 2.31292
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 2.25223
ATG2A autophagy related 2A 2.24888
PRDX1 peroxiredoxin 1 2.24305
VDAC3 voltage-dependent anion channel 3 2.24266
PCGF2 polycomb group ring finger 2 2.23574
CETN1 centrin, EF-hand protein, 1 2.2292
DSTN destrin (actin depolymerizing factor) 2.2266
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 2.22645
SYT17 synaptotagmin XVII 2.20991
LDHB lactate dehydrogenase B 2.19573
BANP BTG3 associated nuclear protein 2.19172
TUBA1A tubulin, alpha 1a 2.18444
ZCCHC8 zinc finger, CCHC domain containing 8 2.17602
CD63 CD63 molecule 2.16191
LPIN2 lipin 2 2.15608
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 2.12367
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.12151
TMEM97 transmembrane protein 97 2.11885
NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae) 2.04485
PGAM1 phosphoglycerate mutase 1 (brain) 2.03463
CRMP1 collapsin response mediator protein 1 2.02842
HCCS holocytochrome c synthase 2.02433
LYST lysosomal trafficking regulator 2.01559
PVRIG poliovirus receptor related immunoglobulin domain containing 2.01453
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 2.00787
APOL6 apolipoprotein L, 6 2.0073
IRAK1 interleukin-1 receptor-associated kinase 1 2.00653
PDGFA platelet-derived growth factor alpha polypeptide 1.99658
PIGP phosphatidylinositol glycan anchor biosynthesis, class P 1.98671
SERTAD4 SERTA domain containing 4 1.98643
RNF39 ring finger protein 39 1.98258
DHRS3 dehydrogenase/reductase (SDR family) member 3 1.98158
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 1.97817
KPNB1 karyopherin (importin) beta 1 1.97402
SUMO4 small ubiquitin-like modifier 4 1.96948
GOSR1 golgi SNAP receptor complex member 1 1.96368
FAM45A family with sequence similarity 45, member A 1.96201
TUBA1B tubulin, alpha 1b 1.95391
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 1.95036
CREB3L2 cAMP responsive element binding protein 3-like 2 1.94492
RUSC1 RUN and SH3 domain containing 1 1.93582
APH1B APH1B gamma secretase subunit 1.9349
AKR1C1 aldo-keto reductase family 1, member C1 1.92716
UFC1 ubiquitin-fold modifier conjugating enzyme 1 1.92466
RBL2 retinoblastoma-like 2 1.90347
GCLC glutamate-cysteine ligase, catalytic subunit 1.89503
TOB2 transducer of ERBB2, 2 1.89083
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated 1.88901
C19ORF54 chromosome 19 open reading frame 54 1.88668
LEF1 lymphoid enhancer-binding factor 1 1.88503
ACTG1 actin gamma 1 1.88428
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 1.8836
ZNF710 zinc finger protein 710 1.88014
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 1.87523
CIB1 calcium and integrin binding 1 (calmyrin) 1.87329
CCDC6 coiled-coil domain containing 6 1.87309
DPF3 D4, zinc and double PHD fingers, family 3 1.86286
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12 1.84474
C6ORF62 chromosome 6 open reading frame 62 1.84235
ZNF25 zinc finger protein 25 1.83937
ITM2B integral membrane protein 2B 1.83624
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 1.82036
SEPT6 septin 6 1.81845
BCL2L13 BCL2-like 13 (apoptosis facilitator) 1.81407
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 1.80017
PIR pirin (iron-binding nuclear protein) 1.79648
PRR4 proline rich 4 (lacrimal) 1.79541
ZNF593 zinc finger protein 593 1.79278
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 1.79071
DNASE1L1 deoxyribonuclease I-like 1 1.78491
JARID2 jumonji, AT rich interactive domain 2 1.78414
RIT1 Ras-like without CAAX 1 1.77984
AP2B1 adaptor-related protein complex 2, beta 1 subunit 1.779
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 1.7703
RRAGC Ras-related GTP binding C 1.76309
HDGF hepatoma-derived growth factor 1.76128
SCAMP2 secretory carrier membrane protein 2 1.75646
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 1.74935
RPL17 ribosomal protein L17 1.7493
CLN5 ceroid-lipofuscinosis, neuronal 5 1.74819
APH1A APH1A gamma secretase subunit 1.74169
LYN LYN proto-oncogene, Src family tyrosine kinase 1.74069
ZSCAN4 zinc finger and SCAN domain containing 4 1.73538
FKSG49 FKSG49 1.72176
MRPS7 mitochondrial ribosomal protein S7 1.7178
NSFL1C NSFL1 (p97) cofactor (p47) 1.71173
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 1.70894
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 1.7075
C8B complement component 8, beta polypeptide 1.70627
NOP16 NOP16 nucleolar protein 1.69378
CBR3 carbonyl reductase 3 1.69252
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 1.68566
FBXW11 F-box and WD repeat domain containing 11 1.68326
PEX11B peroxisomal biogenesis factor 11 beta 1.68239
TGFA transforming growth factor, alpha 1.6809
MYOF myoferlin 1.67091
MYO9A myosin IXA 1.66826
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic 1.66736
KPNA4 karyopherin alpha 4 (importin alpha 3) 1.66493
TRIM66 tripartite motif containing 66 1.65065
CES3 carboxylesterase 3 1.6505
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 1.64894
R3HDM2 R3H domain containing 2 1.64882
GSTA4 glutathione S-transferase alpha 4 1.64287
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 1.62974
PPIEL peptidylprolyl isomerase E-like pseudogene 1.62294
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 1.61913
P3H1 prolyl 3-hydroxylase 1 1.61643
PBX3 pre-B-cell leukemia homeobox 3 1.61367
USO1 USO1 vesicle transport factor 1.61365
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 1.61138
SEC11A SEC11 homolog A (S. cerevisiae) 1.61138
CHMP3 charged multivesicular body protein 3 1.61086
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 1.61074
PGK1 phosphoglycerate kinase 1 1.60782
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 1.6056
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 1.60558
LAMA4 laminin, alpha 4 1.59463
STAT5A signal transducer and activator of transcription 5A 1.5936
TIMP3 TIMP metallopeptidase inhibitor 3 1.58637
RBM28 RNA binding motif protein 28 1.58183
SKP1 S-phase kinase-associated protein 1 1.58166
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 1.57724
KLK12 kallikrein-related peptidase 12 1.57478
WIPF2 WAS/WASL interacting protein family, member 2 1.5746
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.57285
HSPB2 heat shock 27kDa protein 2 1.57114
TXN thioredoxin 1.57025
WDR55 WD repeat domain 55 1.57018
NUP205 nucleoporin 205kDa 1.56497
HMGXB4 HMG box domain containing 4 1.56316
IFNAR2 interferon (alpha, beta and omega) receptor 2 1.55979
HIPK2 homeodomain interacting protein kinase 2 1.55885
CHMP4A charged multivesicular body protein 4A 1.55519
BASP1 brain abundant, membrane attached signal protein 1 1.55506
NIT2 nitrilase family, member 2 1.55417
S100A13 S100 calcium binding protein A13 1.55401
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 1.55329
IFNAR1 interferon (alpha, beta and omega) receptor 1 1.55185
SIRT7 sirtuin 7 1.54469
ADI1 acireductone dioxygenase 1 1.54255
TM9SF3 transmembrane 9 superfamily member 3 1.54098
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 1.53949
BTBD9 BTB (POZ) domain containing 9 1.53894
IDS iduronate 2-sulfatase 1.53773
SMAP1 small ArfGAP 1 1.53493
IPO9 importin 9 1.53448
TMEM50A transmembrane protein 50A 1.53186
MKRN1 makorin ring finger protein 1 1.52791
ZNF239 zinc finger protein 239 1.52593
CXADR coxsackie virus and adenovirus receptor 1.52529
ZNF207 zinc finger protein 207 1.52221
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 1.51781
CCND3 cyclin D3 1.51297
ITCH itchy E3 ubiquitin protein ligase 1.51264
DCPS decapping enzyme, scavenger 1.51084
APOM apolipoprotein M 1.50763
GJC2 gap junction protein, gamma 2, 47kDa 1.50302
TUBA1C tubulin, alpha 1c 1.50251
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 1.49853
DIAPH1 diaphanous-related formin 1 1.49645
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 1.49638
CBR1 carbonyl reductase 1 1.49237
TXNL1 thioredoxin-like 1 1.49186
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 1.48785
C11ORF48 1.48662
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit 1.48597
SLC25A40 solute carrier family 25, member 40 1.48559
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 1.48449
JRK Jrk homolog (mouse) 1.48039
MTCH2 mitochondrial carrier 2 1.47988
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent 1.47926
NR1D1 nuclear receptor subfamily 1, group D, member 1 1.47664
CAMLG calcium modulating ligand 1.47473
C16ORF45 chromosome 16 open reading frame 45 1.47334
LMO2 LIM domain only 2 (rhombotin-like 1) 1.47178
AGTPBP1 ATP/GTP binding protein 1 1.47092
MAEA macrophage erythroblast attacher 1.46517
NOV nephroblastoma overexpressed 1.46358
MITF microphthalmia-associated transcription factor 1.46007
VCL vinculin 1.45946
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 1.45879
SCYL2 SCY1-like 2 (S. cerevisiae) 1.45786
DENND2D DENN/MADD domain containing 2D 1.45642
TGFBRAP1 transforming growth factor, beta receptor associated protein 1 1.45628
DLG5 discs, large homolog 5 (Drosophila) 1.45597
GSTA3 glutathione S-transferase alpha 3 1.44973
ALAS1 5'-aminolevulinate synthase 1 1.44785
KCNK3 potassium channel, two pore domain subfamily K, member 3 1.44528
GORASP2 golgi reassembly stacking protein 2, 55kDa 1.44356
ZWINT ZW10 interacting kinetochore protein 1.44301
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 1.44223
NCOA4 nuclear receptor coactivator 4 1.44198
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) 1.44149
BRD2 bromodomain containing 2 1.44068
EMP2 epithelial membrane protein 2 1.44059
DTNA dystrobrevin, alpha 1.44021
GLI2 GLI family zinc finger 2 1.44015
TYMS thymidylate synthetase 1.43557
RABGAP1L RAB GTPase activating protein 1-like 1.43539
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 1.43451
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 1.43098
GYG1 glycogenin 1 1.43073
CASP10 caspase 10, apoptosis-related cysteine peptidase 1.42775
YIPF1 Yip1 domain family, member 1 1.42389
BAALC brain and acute leukemia, cytoplasmic 1.4235
HIST1H2BK histone cluster 1, H2bk 1.419
HSPA1A heat shock 70kDa protein 1A 1.41774
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 1.41407
PMS2P1 postmeiotic segregation increased 2 pseudogene 1 1.41152
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34 1.40689
GPX3 glutathione peroxidase 3 1.40444
SLC35F2 solute carrier family 35, member F2 1.40334
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 1.40311
TRIM38 tripartite motif containing 38 1.40182
DUSP3 dual specificity phosphatase 3 1.39985
CXXC4 CXXC finger protein 4 1.3984
POLR2F polymerase (RNA) II (DNA directed) polypeptide F 1.39613
MFSD5 major facilitator superfamily domain containing 5 1.3933
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.39177
TMEM41B transmembrane protein 41B 1.3913
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 1.39077
SEC61G Sec61 gamma subunit 1.38984
AKR1C3 aldo-keto reductase family 1, member C3 1.38635
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene 1.38598
LMO4 LIM domain only 4 1.38577
UNK unkempt family zinc finger 1.38478
REPIN1 replication initiator 1 1.38455
FKBP1A FK506 binding protein 1A, 12kDa 1.38297
PID1 phosphotyrosine interaction domain containing 1 1.38002
TSPAN1 tetraspanin 1 1.37769
VCP valosin containing protein 1.37567
WBP1L WW domain binding protein 1-like 1.37408
TMEM187 transmembrane protein 187 1.37279
CNPPD1 cyclin Pas1/PHO80 domain containing 1 1.37135
CDC42SE1 CDC42 small effector 1 1.36814
FASTKD3 FAST kinase domains 3 1.36698
ARL2BP ADP-ribosylation factor-like 2 binding protein 1.36258
SAE1 SUMO1 activating enzyme subunit 1 1.36246
MEA1 male-enhanced antigen 1 1.36246
TMCC1 transmembrane and coiled-coil domain family 1 1.36226
ADCY9 adenylate cyclase 9 1.36176
APTX aprataxin 1.36114
PDCD6IP programmed cell death 6 interacting protein 1.35697
USP9X ubiquitin specific peptidase 9, X-linked 1.35674
LECT2 leukocyte cell-derived chemotaxin 2 1.35418
CA4 carbonic anhydrase IV 1.35332
PSPC1 paraspeckle component 1 1.35145
TULP3 tubby like protein 3 1.35132
SSBP1 single-stranded DNA binding protein 1, mitochondrial 1.34859
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 1.34316
AP4S1 adaptor-related protein complex 4, sigma 1 subunit 1.34185
SSH1 slingshot protein phosphatase 1 1.3407
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 1.34027
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) 1.34021
BABAM1 BRISC and BRCA1 A complex member 1 1.33703
MYO15A myosin XVA 1.33659
COX4I1 cytochrome c oxidase subunit IV isoform 1 1.33514
WDR4 WD repeat domain 4 1.33105
TPBG trophoblast glycoprotein 1.3282
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 1.32794
IRAK3 interleukin-1 receptor-associated kinase 3 1.32759
KLRG1 killer cell lectin-like receptor subfamily G, member 1 1.32554
LOC100506699 uncharacterized LOC100506699 1.3247
PDE8B phosphodiesterase 8B 1.3238
METTL22 methyltransferase like 22 1.32057
PRRC2B proline-rich coiled-coil 2B 1.32037
POLR1C polymerase (RNA) I polypeptide C, 30kDa 1.31903
EPHB1 EPH receptor B1 1.3174
FANCG Fanconi anemia, complementation group G 1.31718
HSPA12A heat shock 70kDa protein 12A 1.31131
RRP1B ribosomal RNA processing 1B 1.30935
ADNP2 ADNP homeobox 2 1.30934
SNX11 sorting nexin 11 1.30614

decreased expression

Symbol Name Standardized Value
MIOS missing oocyte, meiosis regulator, homolog (Drosophila) -4.34834
PHF21A PHD finger protein 21A -3.6903
PRY PTPN13-like, Y-linked -3.23258
RLF rearranged L-myc fusion -3.22211
NUP98 nucleoporin 98kDa -3.1944
RIPK4 receptor-interacting serine-threonine kinase 4 -3.17744
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 -3.17014
PPP1R8 protein phosphatase 1, regulatory subunit 8 -3.09935
FOXA1 forkhead box A1 -3.09201
PFKM phosphofructokinase, muscle -2.95833
FMR1 fragile X mental retardation 1 -2.87838
IRF1 interferon regulatory factor 1 -2.86337
ADSL adenylosuccinate lyase -2.83554
UBAP2L ubiquitin associated protein 2-like -2.80166
GRSF1 G-rich RNA sequence binding factor 1 -2.78755
PTPRT protein tyrosine phosphatase, receptor type, T -2.77278
ACSS3 acyl-CoA synthetase short-chain family member 3 -2.76186
WDR37 WD repeat domain 37 -2.71644
EXT2 exostosin glycosyltransferase 2 -2.64426
LARP7 La ribonucleoprotein domain family, member 7 -2.59186
DNAH9 dynein, axonemal, heavy chain 9 -2.57157
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) -2.56105
SNRPA1 small nuclear ribonucleoprotein polypeptide A' -2.52595
SNX1 sorting nexin 1 -2.51244
GSPT2 G1 to S phase transition 2 -2.49785
LTBP1 latent transforming growth factor beta binding protein 1 -2.4923
HPRT1 hypoxanthine phosphoribosyltransferase 1 -2.48392
PPP6R3 protein phosphatase 6, regulatory subunit 3 -2.4808
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta -2.46302
TPD52L2 tumor protein D52-like 2 -2.46049
ZMYM4 zinc finger, MYM-type 4 -2.45867
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.40952
JAK1 Janus kinase 1 -2.38365
ADGRG6 adhesion G protein-coupled receptor G6 -2.36368
BEX4 brain expressed, X-linked 4 -2.36255
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 -2.34774
RPL4 ribosomal protein L4 -2.28733
SEPHS1 selenophosphate synthetase 1 -2.27592
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -2.26938
GATA6 GATA binding protein 6 -2.26833
SCAPER S-phase cyclin A-associated protein in the ER -2.24723
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) -2.24348
BSPRY B-box and SPRY domain containing -2.23118
SHOC2 soc-2 suppressor of clear homolog (C. elegans) -2.2302
STX8 syntaxin 8 -2.20427
SART1 squamous cell carcinoma antigen recognized by T cells -2.19784
OPA1 optic atrophy 1 (autosomal dominant) -2.18136
TDRD7 tudor domain containing 7 -2.18049
ZNF274 zinc finger protein 274 -2.17964
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -2.17712
MTX2 metaxin 2 -2.15624
MDH2 malate dehydrogenase 2, NAD (mitochondrial) -2.13822
C17ORF85 chromosome 17 open reading frame 85 -2.12683
PIAS3 protein inhibitor of activated STAT, 3 -2.11811
USP25 ubiquitin specific peptidase 25 -2.11692
SPOP speckle-type POZ protein -2.0974
PEX14 peroxisomal biogenesis factor 14 -2.08247
FAM98A family with sequence similarity 98, member A -2.07553
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) -2.07356
CCNI cyclin I -2.06698
KIAA0368 KIAA0368 -2.05667
PNRC2 proline-rich nuclear receptor coactivator 2 -2.04379
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -2.04053
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.03904
ENDOG endonuclease G -2.02781
PHC2 polyhomeotic homolog 2 (Drosophila) -2.02733
C11ORF57 chromosome 11 open reading frame 57 -2.02733
TEFM transcription elongation factor, mitochondrial -2.02349
SERP1 stress-associated endoplasmic reticulum protein 1 -2.01916
MTG1 mitochondrial ribosome-associated GTPase 1 -2.01392
GTF2IRD1 GTF2I repeat domain containing 1 -2.0138
PIGT phosphatidylinositol glycan anchor biosynthesis, class T -2.0071
IQGAP2 IQ motif containing GTPase activating protein 2 -1.99933
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -1.99621
RNF38 ring finger protein 38 -1.99014
HIST1H2BD histone cluster 1, H2bd -1.98468
EIF3D eukaryotic translation initiation factor 3, subunit D -1.98356
RXRA retinoid X receptor, alpha -1.98343
REEP4 receptor accessory protein 4 -1.98206
PYGB phosphorylase, glycogen; brain -1.97981
XK X-linked Kx blood group -1.97327
RALYL RALY RNA binding protein-like -1.96734
PSIP1 PC4 and SFRS1 interacting protein 1 -1.96324
PCDHB11 protocadherin beta 11 -1.96076
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) -1.95884
FIBP fibroblast growth factor (acidic) intracellular binding protein -1.95593
PARP16 poly (ADP-ribose) polymerase family, member 16 -1.94047
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -1.93161
EMC7 ER membrane protein complex subunit 7 -1.91957
FBXL5 F-box and leucine-rich repeat protein 5 -1.91957
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit -1.915
NT5DC3 5'-nucleotidase domain containing 3 -1.91435
SUN1 Sad1 and UNC84 domain containing 1 -1.91135
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) -1.90927
NAP1L1 nucleosome assembly protein 1-like 1 -1.90413
CBX1 chromobox homolog 1 -1.89473
ERGIC3 ERGIC and golgi 3 -1.89313
TFDP1 transcription factor Dp-1 -1.87635
HADH hydroxyacyl-CoA dehydrogenase -1.87609
RNF11 ring finger protein 11 -1.87319
DYNLT3 dynein, light chain, Tctex-type 3 -1.87076
FAM49A family with sequence similarity 49, member A -1.86733
POLD3 polymerase (DNA-directed), delta 3, accessory subunit -1.86079
SP3 Sp3 transcription factor -1.8606
DCP2 decapping mRNA 2 -1.8597
TMEM183A transmembrane protein 183A -1.8583
PCF11 PCF11 cleavage and polyadenylation factor subunit -1.85808
LRPPRC leucine-rich pentatricopeptide repeat containing -1.85322
OPTN optineurin -1.84694
ZNF24 zinc finger protein 24 -1.84632
ABHD14A abhydrolase domain containing 14A -1.8458
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 -1.84164
TRAF3 TNF receptor-associated factor 3 -1.83951
POLR3B polymerase (RNA) III (DNA directed) polypeptide B -1.83105
RCN1 reticulocalbin 1, EF-hand calcium binding domain -1.82717
MAP3K9 mitogen-activated protein kinase kinase kinase 9 -1.82062
EXOSC2 exosome component 2 -1.81656
NTHL1 nth endonuclease III-like 1 (E. coli) -1.81611
TEX2 testis expressed 2 -1.81411
BAG6 BCL2-associated athanogene 6 -1.81143
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 -1.80898
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -1.80124
AP2A2 adaptor-related protein complex 2, alpha 2 subunit -1.79228
EML1 echinoderm microtubule associated protein like 1 -1.7891
THBS4 thrombospondin 4 -1.78634
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 -1.77446
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 -1.77305
SEC13 SEC13 homolog (S. cerevisiae) -1.77052
MBTPS1 membrane-bound transcription factor peptidase, site 1 -1.75362
RHOT1 ras homolog family member T1 -1.74014
CRTC3 CREB regulated transcription coactivator 3 -1.73888
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein -1.73538
MAPK6 mitogen-activated protein kinase 6 -1.73318
KDM5B lysine (K)-specific demethylase 5B -1.73075
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 -1.72363
QRICH1 glutamine-rich 1 -1.72178
MBOAT2 membrane bound O-acyltransferase domain containing 2 -1.72066
BRD7 bromodomain containing 7 -1.71857
FAM175B family with sequence similarity 175, member B -1.71608
PEX16 peroxisomal biogenesis factor 16 -1.7099
CHI3L2 chitinase 3-like 2 -1.70922
MYB v-myb avian myeloblastosis viral oncogene homolog -1.70773
TRIP12 thyroid hormone receptor interactor 12 -1.6961
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -1.69448
AARS alanyl-tRNA synthetase -1.68891
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -1.68727
KIF14 kinesin family member 14 -1.68516
CMC4 C-x(9)-C motif containing 4 -1.68087
C4ORF27 chromosome 4 open reading frame 27 -1.68026
CRNKL1 crooked neck pre-mRNA splicing factor 1 -1.67904
TMEM135 transmembrane protein 135 -1.67793
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae) -1.67611
MORF4L2 mortality factor 4 like 2 -1.66655
MAP2K4 mitogen-activated protein kinase kinase 4 -1.66647
SNRK SNF related kinase -1.65961
PRPS2 phosphoribosyl pyrophosphate synthetase 2 -1.65715
EIF3B eukaryotic translation initiation factor 3, subunit B -1.6552
CALM3 calmodulin 3 (phosphorylase kinase, delta) -1.65228
USP15 ubiquitin specific peptidase 15 -1.64967
PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) -1.64745
BIRC2 baculoviral IAP repeat containing 2 -1.64697
TTC12 tetratricopeptide repeat domain 12 -1.64691
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -1.64323
PEBP1 phosphatidylethanolamine binding protein 1 -1.63605
TMPRSS3 transmembrane protease, serine 3 -1.63428
GOLGA5 golgin A5 -1.63239
MAGEF1 melanoma antigen family F1 -1.62688
EIF3K eukaryotic translation initiation factor 3, subunit K -1.62316
TRAP1 TNF receptor-associated protein 1 -1.62291
MOGS mannosyl-oligosaccharide glucosidase -1.6227
DONSON downstream neighbor of SON -1.61858
ELF2 E74-like factor 2 (ets domain transcription factor) -1.61812
GMNN geminin, DNA replication inhibitor -1.61694
NANS N-acetylneuraminic acid synthase -1.60702
PUF60 poly-U binding splicing factor 60KDa -1.60415
PPP4R1 protein phosphatase 4, regulatory subunit 1 -1.60141
U2AF1 U2 small nuclear RNA auxiliary factor 1 -1.59992
THYN1 thymocyte nuclear protein 1 -1.59718
SARS seryl-tRNA synthetase -1.59606
PRPF39 pre-mRNA processing factor 39 -1.5948
INPP5A inositol polyphosphate-5-phosphatase, 40kDa -1.59338
PDLIM1 PDZ and LIM domain 1 -1.59151
COPZ1 coatomer protein complex, subunit zeta 1 -1.5904
OCRL oculocerebrorenal syndrome of Lowe -1.58832
ELF5 E74-like factor 5 (ets domain transcription factor) -1.5872
SDC4 syndecan 4 -1.58588
POMZP3 POM121 and ZP3 fusion -1.58499
FXYD6 FXYD domain containing ion transport regulator 6 -1.57921
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein -1.5758
TBC1D12 TBC1 domain family, member 12 -1.57415
CDK16 cyclin-dependent kinase 16 -1.57336
SLC30A1 solute carrier family 30 (zinc transporter), member 1 -1.57151
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 -1.56965
FAM53C family with sequence similarity 53, member C -1.56937
ATP11B ATPase, class VI, type 11B -1.56817
IRS1 insulin receptor substrate 1 -1.56717
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -1.56348
SNX7 sorting nexin 7 -1.56273
TOB1 transducer of ERBB2, 1 -1.56098
MRPL39 mitochondrial ribosomal protein L39 -1.55925
OSTM1 osteopetrosis associated transmembrane protein 1 -1.55752
IL33 interleukin 33 -1.55724
GNG12 guanine nucleotide binding protein (G protein), gamma 12 -1.54732
NPAS3 neuronal PAS domain protein 3 -1.54642
WTAP Wilms tumor 1 associated protein -1.54392
ZNF263 zinc finger protein 263 -1.54379
UFSP2 UFM1-specific peptidase 2 -1.542
BDH2 3-hydroxybutyrate dehydrogenase, type 2 -1.53699
EPHX2 epoxide hydrolase 2, cytoplasmic -1.53453
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) -1.5317
NUP155 nucleoporin 155kDa -1.52885
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -1.52881
PRUNE prune exopolyphosphatase -1.52797
NCL nucleolin -1.52498
UNC45A unc-45 homolog A (C. elegans) -1.52269
RB1CC1 RB1-inducible coiled-coil 1 -1.51874
JUP junction plakoglobin -1.51842
RBMS1 RNA binding motif, single stranded interacting protein 1 -1.51787
LOC100131510 uncharacterized LOC100131510 -1.51608
TFCP2 transcription factor CP2 -1.50958
RNF139 ring finger protein 139 -1.50436
MZT2A mitotic spindle organizing protein 2A -1.5023
CSNK1G2 casein kinase 1, gamma 2 -1.50164
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 -1.50124
LMO3 LIM domain only 3 (rhombotin-like 2) -1.50122
GCC1 GRIP and coiled-coil domain containing 1 -1.49978
SEC31A SEC31 homolog A (S. cerevisiae) -1.49909
CGRRF1 cell growth regulator with ring finger domain 1 -1.49892
ZNF813 zinc finger protein 813 -1.49665
TRIM37 tripartite motif containing 37 -1.49526
KATNA1 katanin p60 (ATPase containing) subunit A 1 -1.49515
POT1 protection of telomeres 1 -1.49351
UNC93B1 unc-93 homolog B1 (C. elegans) -1.49014
NAE1 NEDD8 activating enzyme E1 subunit 1 -1.48473
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta -1.47464
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -1.4745
FAM8A1 family with sequence similarity 8, member A1 -1.47337
DOCK9 dedicator of cytokinesis 9 -1.47018
ERBB3 erb-b2 receptor tyrosine kinase 3 -1.46992
RNF219 ring finger protein 219 -1.4658
ZBTB10 zinc finger and BTB domain containing 10 -1.45928
NFS1 NFS1 cysteine desulfurase -1.45839
ATXN7L3B ataxin 7-like 3B -1.45619
ADAM10 ADAM metallopeptidase domain 10 -1.45393
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -1.45267
C11ORF95 chromosome 11 open reading frame 95 -1.45194
C19ORF53 chromosome 19 open reading frame 53 -1.4513
PTGES3 prostaglandin E synthase 3 (cytosolic) -1.44951
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 -1.44801
USP21 ubiquitin specific peptidase 21 -1.44566
TCP1 t-complex 1 -1.43905
SF3A1 splicing factor 3a, subunit 1, 120kDa -1.43733
NEK7 NIMA-related kinase 7 -1.42666
F2 coagulation factor II (thrombin) -1.42421
TMEM87A transmembrane protein 87A -1.41398
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 -1.41129
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -1.40984
TFF2 trefoil factor 2 -1.40891
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic -1.40737
GLCE glucuronic acid epimerase -1.40614
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa -1.40456
PLCL1 phospholipase C-like 1 -1.40177
ADD1 adducin 1 (alpha) -1.40129
DAPK1 death-associated protein kinase 1 -1.39465
SCP2 sterol carrier protein 2 -1.39301
MSL3 male-specific lethal 3 homolog (Drosophila) -1.392
SMAD2 SMAD family member 2 -1.39018
ANKMY1 ankyrin repeat and MYND domain containing 1 -1.38909
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 -1.38842
SMC2 structural maintenance of chromosomes 2 -1.38672
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) -1.38544
RPAP3 RNA polymerase II associated protein 3 -1.38186
CIAO1 cytosolic iron-sulfur assembly component 1 -1.37968
GAS2L1 growth arrest-specific 2 like 1 -1.37727
SOX9 SRY (sex determining region Y)-box 9 -1.37622
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -1.37492
CASC3 cancer susceptibility candidate 3 -1.37418
RAD51C RAD51 paralog C -1.37334
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 -1.37251
C7ORF25 chromosome 7 open reading frame 25 -1.37098
CKB creatine kinase, brain -1.37044
FGFR2 fibroblast growth factor receptor 2 -1.37
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon -1.36554
SHROOM2 shroom family member 2 -1.36435
PAPD5 PAP associated domain containing 5 -1.36347
RAB6B RAB6B, member RAS oncogene family -1.36178
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) -1.36169
RARB retinoic acid receptor, beta -1.36158
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 -1.36115
DSE dermatan sulfate epimerase -1.35474
MUT methylmalonyl CoA mutase -1.35433
OR10H3 olfactory receptor, family 10, subfamily H, member 3 -1.35303
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 -1.35231
PLCL2 phospholipase C-like 2 -1.34995
NARS asparaginyl-tRNA synthetase -1.34451
FBN1 fibrillin 1 -1.34134
RFC3 replication factor C (activator 1) 3, 38kDa -1.33888
COPS7B COP9 signalosome subunit 7B -1.33812
SPEF1 sperm flagellar 1 -1.3381
PRPF8 pre-mRNA processing factor 8 -1.33293