C4b binding protein levels Gene Set

Dataset GWAS Catalog SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A C4BP measurement is the quantification of C4BP, it controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component. (Uniprot defintion) (Experimental Factor Ontology, EFO_0004572)
External Link https://www.ebi.ac.uk/gwas/search?query=C4b binding protein levels
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Genes

1 genes associated with the C4b binding protein levels phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
C4BPB complement component 4 binding protein, beta 0.552116