Bone Density Gene Set

Dataset dbGAP Gene-Trait Associations
Category disease or phenotype associations
Type trait
Description The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS. (Experimental Factor Ontology, EFO_0003923)
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Genes

73 genes associated with the trait Bone Density in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

Symbol Name Standardized Value
BPIFA3 BPI fold containing family A, member 3 1.11459
WLS wntless Wnt ligand secretion mediator 1.10359
ARHGAP10 Rho GTPase activating protein 10 1.06957
C7ORF76 chromosome 7 open reading frame 76 1.03374
LRP5 low density lipoprotein receptor-related protein 5 1.02893
FAM3C family with sequence similarity 3, member C 1.01477
CCDC170 coiled-coil domain containing 170 0.995026
GABPB1 GA binding protein transcription factor, beta subunit 1 0.981419
ESR1 estrogen receptor 1 0.960111
VIT vitrin 0.888962
FSIP1 fibrous sheath interacting protein 1 0.858074
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.836808
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.807597
ARHGAP1 Rho GTPase activating protein 1 0.807263
ZNF408 zinc finger protein 408 0.807263
SP7 Sp7 transcription factor 0.763999
RORA RAR-related orphan receptor A 0.758825
FAM155A family with sequence similarity 155, member A 0.753181
HDAC5 histone deacetylase 5 0.731179
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 0.731179
SPTBN1 spectrin, beta, non-erythrocytic 1 0.731179
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.696087
JAG1 jagged 1 0.685324
TSPAN7 tetraspanin 7 0.65167
DGKB diacylglycerol kinase, beta 90kDa 0.62066
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.617538
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.590402
CD38 CD38 molecule 0.578029
INO80 INO80 complex subunit 0.564862
RGS8 regulator of G-protein signaling 8 0.560791
CKAP5 cytoskeleton associated protein 5 0.527821
IBSP integrin-binding sialoprotein 0.518003
C17ORF53 chromosome 17 open reading frame 53 0.50886
P4HA3 prolyl 4-hydroxylase, alpha polypeptide III 0.505794
CTNNBL1 catenin, beta like 1 0.50084
TGFBR3 transforming growth factor, beta receptor III 0.50084
CCDC158 coiled-coil domain containing 158 0.484942
PRKCE protein kinase C, epsilon 0.474964
IL21R interleukin 21 receptor 0.443956
ADGRV1 adhesion G protein-coupled receptor V1 0.43783
RBMS3 RNA binding motif, single stranded interacting protein 3 0.412386
CNTNAP2 contactin associated protein-like 2 0.406869
HDAC9 histone deacetylase 9 0.389767
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 0.378926
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 0.378873
CSMD1 CUB and Sushi multiple domains 1 0.372195
FGF14 fibroblast growth factor 14 0.370694
AMPH amphiphysin 0.362795
MCUR1 mitochondrial calcium uniporter regulator 1 0.347937
SPAG16 sperm associated antigen 16 0.34289
PCNT pericentrin 0.332561
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.301272
WIF1 WNT inhibitory factor 1 0.297534
PRR16 proline rich 16 0.269382
TRIM9 tripartite motif containing 9 0.260793
CNOT6 CCR4-NOT transcription complex, subunit 6 0.205553
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.181412
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.154657
PRDM6 PR domain containing 6 0.139944
DLC1 DLC1 Rho GTPase activating protein 0.133714
ARID1B AT rich interactive domain 1B (SWI1-like) 0.115408
CCDC81 coiled-coil domain containing 81 0.10543
RHOBTB1 Rho-related BTB domain containing 1 0.101514
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 0.101514
MTMR2 myotubularin related protein 2 0.089416
PARG poly (ADP-ribose) glycohydrolase 0.088544
LRRC75A-AS1 LRRC75A antisense RNA 1 0.086808
ERBB4 erb-b2 receptor tyrosine kinase 4 0.083361
IQSEC3 IQ motif and Sec7 domain 3 0.080372
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 0.072386
PDZK1 PDZ domain containing 1 0.068318
THRB thyroid hormone receptor, beta 0.065983
SLC14A2 solute carrier family 14 (urea transporter), member 2 0.060053