BRD-U86922168_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-U86922168_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF3 activating transcription factor 3
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
CCNL1 cyclin L1
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
COL9A3 collagen, type IX, alpha 3
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DNMBP dynamin binding protein
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
FADS1 fatty acid desaturase 1
FNDC3B fibronectin type III domain containing 3B
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
H1F0 H1 histone family, member 0
HIST1H1C histone cluster 1, H1c
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IRF1 interferon regulatory factor 1
JUNB jun B proto-oncogene
KIAA0226L KIAA0226-like
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NINJ1 ninjurin 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTBP2 polypyrimidine tract binding protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SORBS2 sorbin and SH3 domain containing 2
SRRM2 serine/arginine repetitive matrix 2
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
WEE1 WEE1 G2 checkpoint kinase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa
B3GNT1
CA2 carbonic anhydrase II
CCNE2 cyclin E2
CHGB chromogranin B
COL3A1 collagen, type III, alpha 1
DEGS1 delta(4)-desaturase, sphingolipid 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
FGL2 fibrinogen-like 2
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATA3 GATA binding protein 3
GNAS GNAS complex locus
HAT1 histone acetyltransferase 1
HMG20B high mobility group 20B
JAG1 jagged 1
KCTD12 potassium channel tetramerization domain containing 12
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LPAR6 lysophosphatidic acid receptor 6
MAT2A methionine adenosyltransferase II, alpha
MCAM melanoma cell adhesion molecule
MREG melanoregulin
PCNA proliferating cell nuclear antigen
RNASE6 ribonuclease, RNase A family, k6
RNF130 ring finger protein 130
RPIA ribose 5-phosphate isomerase A
S100A9 S100 calcium binding protein A9
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
TMEM230 transmembrane protein 230
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOX3 TOX high mobility group box family member 3
TUBB6 tubulin, beta 6 class V
UBL3 ubiquitin-like 3