BRD-U86922168_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

261 genes differentially expressed following the BRD-U86922168_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
ANKRD12 ankyrin repeat domain 12
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BCL10 B-cell CLL/lymphoma 10
BCL3 B-cell CLL/lymphoma 3
BIRC3 baculoviral IAP repeat containing 3
BTG1 B-cell translocation gene 1, anti-proliferative
CAB39 calcium binding protein 39
CCNL1 cyclin L1
CDK17 cyclin-dependent kinase 17
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFLAR CASP8 and FADD-like apoptosis regulator
CHIC2 cysteine-rich hydrophobic domain 2
CHMP2B charged multivesicular body protein 2B
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLX2 distal-less homeobox 2
DNMBP dynamin binding protein
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF1 eukaryotic translation initiation factor 1
ELOVL5 ELOVL fatty acid elongase 5
EREG epiregulin
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FBN2 fibrillin 2
FEM1C fem-1 homolog c (C. elegans)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GALC galactosylceramidase
GDF15 growth differentiation factor 15
GMFB glia maturation factor, beta
GPRC5A G protein-coupled receptor, class C, group 5, member A
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AG histone cluster 1, H2ag
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HMOX1 heme oxygenase 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGFBP4 insulin-like growth factor binding protein 4
IL11 interleukin 11
IL1RL1 interleukin 1 receptor-like 1
IL6 interleukin 6
INPP1 inositol polyphosphate-1-phosphatase
IRF1 interferon regulatory factor 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT19 keratin 19, type I
LAMA3 laminin, alpha 3
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LOC81691 exonuclease NEF-sp
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MCL1 myeloid cell leukemia 1
MET MET proto-oncogene, receptor tyrosine kinase
MIR22HG MIR22 host gene
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
NAMPT nicotinamide phosphoribosyltransferase
NFE2L2 nuclear factor, erythroid 2-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRG1 neuregulin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPL1 nucleoporin like 1
P3H2 prolyl 3-hydroxylase 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPIF peptidylprolyl isomerase F
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTX3 pentraxin 3, long
RAB9A RAB9A, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RLF rearranged L-myc fusion
RNF19B ring finger protein 19B
RNMT RNA (guanine-7-) methyltransferase
RUNX3 runt-related transcription factor 3
RYBP RING1 and YY1 binding protein
S100A12 S100 calcium binding protein A12
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SIK3 SIK family kinase 3
SIRT1 sirtuin 1
SMAD3 SMAD family member 3
SMOX spermine oxidase
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPAG9 sperm associated antigen 9
SQSTM1 sequestosome 1
STK17A serine/threonine kinase 17a
SWAP70 SWAP switching B-cell complex 70kDa subunit
TERF2IP telomeric repeat binding factor 2, interacting protein
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNPO1 transportin 1
TRH thyrotropin-releasing hormone
TRIB1 tribbles pseudokinase 1
TSC22D1 TSC22 domain family, member 1
TSC22D2 TSC22 domain family, member 2
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
UBAP1 ubiquitin associated protein 1
UBXN7 UBX domain protein 7
UPP1 uridine phosphorylase 1
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
WEE1 WEE1 G2 checkpoint kinase
XIST X inactive specific transcript (non-protein coding)
ZBTB16 zinc finger and BTB domain containing 16
ZBTB20 zinc finger and BTB domain containing 20
ZBTB43 zinc finger and BTB domain containing 43
ZFP36 ZFP36 ring finger protein
ZNF165 zinc finger protein 165
ZNF24 zinc finger protein 24

decreased expression

Symbol Name
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
B3GNT1
BCAP31 B-cell receptor-associated protein 31
BCHE butyrylcholinesterase
CALD1 caldesmon 1
CALU calumenin
CAPG capping protein (actin filament), gelsolin-like
CD99 CD99 molecule
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CETN2 centrin, EF-hand protein, 2
CNPY2 canopy FGF signaling regulator 2
COL6A1 collagen, type VI, alpha 1
COL8A2 collagen, type VIII, alpha 2
COMT catechol-O-methyltransferase
CP ceruloplasmin (ferroxidase)
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DES desmin
DGAT1 diacylglycerol O-acyltransferase 1
DHCR24 24-dehydrocholesterol reductase
DHRS1 dehydrogenase/reductase (SDR family) member 1
DPT dermatopontin
EHMT2 euchromatic histone-lysine N-methyltransferase 2
EIF4B eukaryotic translation initiation factor 4B
FABP1 fatty acid binding protein 1, liver
FBLN1 fibulin 1
FHL1 four and a half LIM domains 1
GPNMB glycoprotein (transmembrane) nmb
HEG1 heart development protein with EGF-like domains 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
ICMT isoprenylcysteine carboxyl methyltransferase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
KANK2 KN motif and ankyrin repeat domains 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDM5D lysine (K)-specific demethylase 5D
LY6E lymphocyte antigen 6 complex, locus E
MCAM melanoma cell adhesion molecule
MEIS1 Meis homeobox 1
MGP matrix Gla protein
MREG melanoregulin
MXRA5 matrix-remodelling associated 5
NME4 NME/NM23 nucleoside diphosphate kinase 4
P4HB prolyl 4-hydroxylase, beta polypeptide
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PARP1 poly (ADP-ribose) polymerase 1
PCP4 Purkinje cell protein 4
PEBP1 phosphatidylethanolamine binding protein 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PSCA prostate stem cell antigen
PTGIS prostaglandin I2 (prostacyclin) synthase
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RAB4A RAB4A, member RAS oncogene family
RNF130 ring finger protein 130
RPA1 replication protein A1, 70kDa
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
SAMM50 SAMM50 sorting and assembly machinery component
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A1 secretoglobin, family 2A, member 1
SDC2 syndecan 2
SEPT11 septin 11
SERINC5 serine incorporator 5
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SRSF1 serine/arginine-rich splicing factor 1
SSR1 signal sequence receptor, alpha
STEAP3 STEAP family member 3, metalloreductase
STIP1 stress-induced phosphoprotein 1
TFDP1 transcription factor Dp-1
TM9SF2 transmembrane 9 superfamily member 2
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM109 transmembrane protein 109
TMEM97 transmembrane protein 97
TNS1 tensin 1
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN13 tetraspanin 13
TTR transthyretin
TUSC3 tumor suppressor candidate 3
ZDHHC11 zinc finger, DHHC-type containing 11