BRD-U86222656_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

225 genes differentially expressed following the BRD-U86222656_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADGRL4 adhesion G protein-coupled receptor L4
ADM adrenomedullin
ARG2 arginase 2
ARL4C ADP-ribosylation factor-like 4C
ARMCX1 armadillo repeat containing, X-linked 1
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
C10ORF10 chromosome 10 open reading frame 10
C3ORF14 chromosome 3 open reading frame 14
C6ORF62 chromosome 6 open reading frame 62
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA1 cyclin A1
CD163 CD163 molecule
CD93 CD93 molecule
CGRRF1 cell growth regulator with ring finger domain 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CRABP1 cellular retinoic acid binding protein 1
DDIT3 DNA-damage-inducible transcript 3
DENND1B DENN/MADD domain containing 1B
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
DUSP1 dual specificity phosphatase 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDN1 endothelin 1
EDNRA endothelin receptor type A
EGLN3 egl-9 family hypoxia-inducible factor 3
EML1 echinoderm microtubule associated protein like 1
EPAS1 endothelial PAS domain protein 1
EVI2A ecotropic viral integration site 2A
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM69A family with sequence similarity 69, member A
FBXL12 F-box and leucine-rich repeat protein 12
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GJA1 gap junction protein, alpha 1, 43kDa
GMFG glia maturation factor, gamma
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GREM1 gremlin 1, DAN family BMP antagonist
HDAC9 histone deacetylase 9
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
HPGDS hematopoietic prostaglandin D synthase
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDO1 indoleamine 2,3-dioxygenase 1
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
INHBB inhibin, beta B
INSM1 insulinoma-associated 1
JUN jun proto-oncogene
KCNK3 potassium channel, two pore domain subfamily K, member 3
KDR kinase insert domain receptor
LAMP3 lysosomal-associated membrane protein 3
LAPTM5 lysosomal protein transmembrane 5
LMO3 LIM domain only 3 (rhombotin-like 2)
LRP12 low density lipoprotein receptor-related protein 12
MDK midkine (neurite growth-promoting factor 2)
MEIS2 Meis homeobox 2
MLPH melanophilin
MMP10 matrix metallopeptidase 10
MSN moesin
MT1M metallothionein 1M
NEFH neurofilament, heavy polypeptide
NPTX2 neuronal pentraxin II
NRCAM neuronal cell adhesion molecule
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
P3H2 prolyl 3-hydroxylase 2
PDCD10 programmed cell death 10
PDZD2 PDZ domain containing 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PKP2 plakophilin 2
PLAU plasminogen activator, urokinase
PLVAP plasmalemma vesicle associated protein
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRKCH protein kinase C, eta
PRKCI protein kinase C, iota
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
RB1CC1 RB1-inducible coiled-coil 1
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
RNASE6 ribonuclease, RNase A family, k6
RND3 Rho family GTPase 3
SCG2 secretogranin II
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCN3A sodium channel, voltage gated, type III alpha subunit
SFRP4 secreted frizzled-related protein 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
ST18 suppression of tumorigenicity 18, zinc finger
STC1 stanniocalcin 1
STK38L serine/threonine kinase 38 like
STON1 stonin 1
TDP2 tyrosyl-DNA phosphodiesterase 2
TEK TEK tyrosine kinase, endothelial
TESK1 testis-specific kinase 1
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMEM30B transmembrane protein 30B
TMSB15A thymosin beta 15a
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM36 tripartite motif containing 36
TYROBP TYRO protein tyrosine kinase binding protein
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
WARS tryptophanyl-tRNA synthetase
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
ACSL1 acyl-CoA synthetase long-chain family member 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMD1 adenosylmethionine decarboxylase 1
ANXA3 annexin A3
ARG1 arginase 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BCLAF1 BCL2-associated transcription factor 1
CCNF cyclin F
CD302 CD302 molecule
CDC25A cell division cycle 25A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHD7 chromodomain helicase DNA binding protein 7
CHERP calcium homeostasis endoplasmic reticulum protein
CHPT1 choline phosphotransferase 1
COL9A3 collagen, type IX, alpha 3
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CST3 cystatin C
CTSH cathepsin H
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
ECI2 enoyl-CoA delta isomerase 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELANE elastase, neutrophil expressed
ELOVL2 ELOVL fatty acid elongase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM198B family with sequence similarity 198, member B
FAM46A family with sequence similarity 46, member A
FBLN5 fibulin 5
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FOXC1 forkhead box C1
GLDC glycine dehydrogenase (decarboxylating)
GMDS GDP-mannose 4,6-dehydratase
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GRWD1 glutamate-rich WD repeat containing 1
GSPT1 G1 to S phase transition 1
GSTM3 glutathione S-transferase mu 3 (brain)
HHEX hematopoietically expressed homeobox
HLF hepatic leukemia factor
IER3 immediate early response 3
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP4 insulin-like growth factor binding protein 4
IL1RN interleukin 1 receptor antagonist
KRT18 keratin 18, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMP1 lysosomal-associated membrane protein 1
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LTF lactotransferrin
MAP2K3 mitogen-activated protein kinase kinase 3
MARCKSL1 MARCKS-like 1
METTL7A methyltransferase like 7A
MFSD10 major facilitator superfamily domain containing 10
MGP matrix Gla protein
MRPS30 mitochondrial ribosomal protein S30
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUP98 nucleoporin 98kDa
PEBP1 phosphatidylethanolamine binding protein 1
PGM1 phosphoglucomutase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PPIF peptidylprolyl isomerase F
PRKCA protein kinase C, alpha
PRKCZ protein kinase C, zeta
QDPR quinoid dihydropteridine reductase
RELN reelin
RNASET2 ribonuclease T2
RPS26 ribosomal protein S26
S100P S100 calcium binding protein P
SERBP1 SERPINE1 mRNA binding protein 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
SIAH2 siah E3 ubiquitin protein ligase 2
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLPI secretory leukocyte peptidase inhibitor
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
SPATS2L spermatogenesis associated, serine-rich 2-like
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACSTD2 tumor-associated calcium signal transducer 2
TARBP1 TAR (HIV-1) RNA binding protein 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLR4 toll-like receptor 4
UBE3C ubiquitin protein ligase E3C
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZBTB18 zinc finger and BTB domain containing 18
ZNF586 zinc finger protein 586