BRD-U82589721_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-U82589721_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALB albumin
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALDOB aldolase B, fructose-bisphosphate
CALD1 caldesmon 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CLEC2B C-type lectin domain family 2, member B
COL4A5 collagen, type IV, alpha 5
DEFA4 defensin, alpha 4, corticostatin
DPP4 dipeptidyl-peptidase 4
DPYD dihydropyrimidine dehydrogenase
EREG epiregulin
FCGBP Fc fragment of IgG binding protein
FLNA filamin A, alpha
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GAL galanin/GMAP prepropeptide
GANAB glucosidase, alpha; neutral AB
GATA3 GATA binding protein 3
GJA1 gap junction protein, alpha 1, 43kDa
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-G major histocompatibility complex, class I, G
IGFBP5 insulin-like growth factor binding protein 5
ITGB7 integrin, beta 7
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF6 Kruppel-like factor 6
LAMP1 lysosomal-associated membrane protein 1
LAPTM4B lysosomal protein transmembrane 4 beta
MME membrane metallo-endopeptidase
MVP major vault protein
NELL2 NEL-like 2 (chicken)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NT5E 5'-nucleotidase, ecto (CD73)
NUCB1 nucleobindin 1
OPTN optineurin
PBX3 pre-B-cell leukemia homeobox 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PRTN3 proteinase 3
PRUNE2 prune homolog 2 (Drosophila)
PYCARD PYD and CARD domain containing
RGCC regulator of cell cycle
SFRP1 secreted frizzled-related protein 1
TDO2 tryptophan 2,3-dioxygenase
THBS1 thrombospondin 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPP1 tripeptidyl peptidase I
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TWIST1 twist family bHLH transcription factor 1

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AQP3 aquaporin 3 (Gill blood group)
ARMT1 acidic residue methyltransferase 1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AURKA aurora kinase A
C3ORF14 chromosome 3 open reading frame 14
CCNA2 cyclin A2
CDKN3 cyclin-dependent kinase inhibitor 3
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CTSH cathepsin H
CXCL12 chemokine (C-X-C motif) ligand 12
DACH1 dachshund family transcription factor 1
DCK deoxycytidine kinase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF4E eukaryotic translation initiation factor 4E
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EXOSC8 exosome component 8
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GMFB glia maturation factor, beta
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX3 glutathione peroxidase 3
GRSF1 G-rich RNA sequence binding factor 1
GRWD1 glutamate-rich WD repeat containing 1
HIST1H4C histone cluster 1, H4c
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB8 heat shock 22kDa protein 8
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KRT15 keratin 15, type I
LBR lamin B receptor
LMO2 LIM domain only 2 (rhombotin-like 1)
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MNAT1 MNAT CDK-activating kinase assembly factor 1
MORC4 MORC family CW-type zinc finger 4
MREG melanoregulin
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
ODC1 ornithine decarboxylase 1
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PDGFA platelet-derived growth factor alpha polypeptide
PEX3 peroxisomal biogenesis factor 3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PTGDS prostaglandin D2 synthase 21kDa (brain)
QKI QKI, KH domain containing, RNA binding
RAD51C RAD51 paralog C
RAE1 ribonucleic acid export 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RGS13 regulator of G-protein signaling 13
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
SACS sacsin molecular chaperone
SFN stratifin
SMAGP small cell adhesion glycoprotein
SNX11 sorting nexin 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPDL1 spindle apparatus coiled-coil protein 1
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
TBP TATA box binding protein
TEX10 testis expressed 10
TIPIN TIMELESS interacting protein
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM5 transmembrane protein 5
TRIM16 tripartite motif containing 16
TSPAN13 tetraspanin 13
TUBA4A tubulin, alpha 4a
TYMS thymidylate synthetase
UGDH UDP-glucose 6-dehydrogenase
USP22 ubiquitin specific peptidase 22
VRK1 vaccinia related kinase 1
ZMYM2 zinc finger, MYM-type 2
ZWILCH zwilch kinetochore protein