BRD-U82589721_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-U82589721_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADCY9 adenylate cyclase 9
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1C3 aldo-keto reductase family 1, member C3
ALB albumin
ASPN asporin
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AZU1 azurocidin 1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CETN2 centrin, EF-hand protein, 2
CTSG cathepsin G
CXCL10 chemokine (C-X-C motif) ligand 10
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DEFB1 defensin, beta 1
EGFL6 EGF-like-domain, multiple 6
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EXPH5 exophilin 5
F13A1 coagulation factor XIII, A1 polypeptide
FOLR1 folate receptor 1 (adult)
FUCA1 fucosidase, alpha-L- 1, tissue
FZD5 frizzled class receptor 5
GAS1 growth arrest-specific 1
GFPT1 glutamine--fructose-6-phosphate transaminase 1
H2BFS H2B histone family, member S (pseudogene)
HHEX hematopoietically expressed homeobox
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HLA-B major histocompatibility complex, class I, B
HMGN5 high mobility group nucleosome binding domain 5
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGF1R insulin-like growth factor 1 receptor
IRS2 insulin receptor substrate 2
KDM3A lysine (K)-specific demethylase 3A
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
MAPT microtubule-associated protein tau
MEIS1 Meis homeobox 1
MFAP5 microfibrillar associated protein 5
MXI1 MAX interactor 1, dimerization protein
MYB v-myb avian myeloblastosis viral oncogene homolog
NQO1 NAD(P)H dehydrogenase, quinone 1
OAT ornithine aminotransferase
OPTN optineurin
PBX3 pre-B-cell leukemia homeobox 3
PDGFRL platelet-derived growth factor receptor-like
PTGER4 prostaglandin E receptor 4 (subtype EP4)
QPRT quinolinate phosphoribosyltransferase
RTN3 reticulon 3
SEC14L1 SEC14-like 1 (S. cerevisiae)
SFRP4 secreted frizzled-related protein 4
SLC39A6 solute carrier family 39 (zinc transporter), member 6
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TMEM2 transmembrane protein 2
TMEM50A transmembrane protein 50A
TNNT1 troponin T type 1 (skeletal, slow)
TPP1 tripeptidyl peptidase I
WNK1 WNK lysine deficient protein kinase 1
WT1 Wilms tumor 1

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
CCNA2 cyclin A2
CD58 CD58 molecule
CSE1L CSE1 chromosome segregation 1-like (yeast)
CX3CR1 chemokine (C-X3-C motif) receptor 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
FAM216A family with sequence similarity 216, member A
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GRWD1 glutamate-rich WD repeat containing 1
HOMER1 homer scaffolding protein 1
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
IGSF6 immunoglobulin superfamily, member 6
IL13RA2 interleukin 13 receptor, alpha 2
INPP1 inositol polyphosphate-1-phosphatase
KCTD12 potassium channel tetramerization domain containing 12
LBR lamin B receptor
LPXN leupaxin
MAT2A methionine adenosyltransferase II, alpha
MET MET proto-oncogene, receptor tyrosine kinase
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
MYC v-myc avian myelocytomatosis viral oncogene homolog
N4BP2L2 NEDD4 binding protein 2-like 2
ODC1 ornithine decarboxylase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PWP1 PWP1 homolog (S. cerevisiae)
RAE1 ribonucleic acid export 1
RFC3 replication factor C (activator 1) 3, 38kDa
RGS2 regulator of G-protein signaling 2
SCRG1 stimulator of chondrogenesis 1
SDC4 syndecan 4
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMAGP small cell adhesion glycoprotein
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
STAMBP STAM binding protein
TBL2 transducin (beta)-like 2
TEX10 testis expressed 10
TM4SF1 transmembrane 4 L six family member 1
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UPP1 uridine phosphorylase 1
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
ZWILCH zwilch kinetochore protein