BRD-U74615290_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

71 genes differentially expressed following the BRD-U74615290_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AQP1 aquaporin 1 (Colton blood group)
ARMCX1 armadillo repeat containing, X-linked 1
CA2 carbonic anhydrase II
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL8 chemokine (C-C motif) ligand 8
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
COL3A1 collagen, type III, alpha 1
DCLK1 doublecortin-like kinase 1
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
EGFL6 EGF-like-domain, multiple 6
FRZB frizzled-related protein
GPM6B glycoprotein M6B
GPX2 glutathione peroxidase 2
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
IFI44L interferon-induced protein 44-like
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ISG15 ISG15 ubiquitin-like modifier
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LTBP1 latent transforming growth factor beta binding protein 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MX1 MX dynamin-like GTPase 1
POSTN periostin, osteoblast specific factor
PRR7 proline rich 7 (synaptic)
RPS4Y1 ribosomal protein S4, Y-linked 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SFN stratifin
TDO2 tryptophan 2,3-dioxygenase
TNFAIP6 tumor necrosis factor, alpha-induced protein 6

decreased expression

Symbol Name
ACAT1 acetyl-CoA acetyltransferase 1
ACOT9 acyl-CoA thioesterase 9
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANPEP alanyl (membrane) aminopeptidase
AXL AXL receptor tyrosine kinase
C3 complement component 3
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
FAM57A family with sequence similarity 57, member A
FBXO21 F-box protein 21
FOS FBJ murine osteosarcoma viral oncogene homolog
KRT18 keratin 18, type I
MOK MOK protein kinase
MSLN mesothelin
MXRA7 matrix-remodelling associated 7
NID1 nidogen 1
PEG10 paternally expressed 10
PKP4 plakophilin 4
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
PNMA1 paraneoplastic Ma antigen 1
PTX3 pentraxin 3, long
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RND3 Rho family GTPase 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
STK17A serine/threonine kinase 17a
TLE4 transducin-like enhancer of split 4
TM4SF1 transmembrane 4 L six family member 1
TUBA1A tubulin, alpha 1a
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
WT1 Wilms tumor 1
ZBTB18 zinc finger and BTB domain containing 18