BRD-U73238814_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-U73238814_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDOC aldolase C, fructose-bisphosphate
ANXA1 annexin A1
ANXA4 annexin A4
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
CAST calpastatin
CD52 CD52 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COMP cartilage oligomeric matrix protein
CRISP3 cysteine-rich secretory protein 3
CTSA cathepsin A
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP4 dual specificity phosphatase 4
ESYT1 extended synaptotagmin-like protein 1
FRZB frizzled-related protein
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GBAP1 glucosidase, beta, acid pseudogene 1
GNAS GNAS complex locus
GPX3 glutathione peroxidase 3
GRN granulin
HIST1H2BD histone cluster 1, H2bd
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMOX1 heme oxygenase 1
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KRT13 keratin 13, type I
KRT18 keratin 18, type I
L1CAM L1 cell adhesion molecule
LAMP1 lysosomal-associated membrane protein 1
LBH limb bud and heart development
LCN2 lipocalin 2
LXN latexin
LYPD3 LY6/PLAUR domain containing 3
MAP1B microtubule-associated protein 1B
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MCOLN1 mucolipin 1
MSLN mesothelin
MYH10 myosin, heavy chain 10, non-muscle
NNMT nicotinamide N-methyltransferase
NPTX2 neuronal pentraxin II
OBSL1 obscurin-like 1
OLFM4 olfactomedin 4
PCSK1 proprotein convertase subtilisin/kexin type 1
PDZK1IP1 PDZK1 interacting protein 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLIN2 perilipin 2
PLSCR3 phospholipid scramblase 3
PNPLA6 patatin-like phospholipase domain containing 6
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTX3 pentraxin 3, long
RAP2A RAP2A, member of RAS oncogene family
RND3 Rho family GTPase 3
RNF144A ring finger protein 144A
RRAGD Ras-related GTP binding D
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLPI secretory leukocyte peptidase inhibitor
SPRR3 small proline-rich protein 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THBS2 thrombospondin 2
TPP1 tripeptidyl peptidase I
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
ADAMDEC1 ADAM-like, decysin 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATAD2 ATPase family, AAA domain containing 2
AUTS2 autism susceptibility candidate 2
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CEP55 centrosomal protein 55kDa
CKB creatine kinase, brain
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
CTSH cathepsin H
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EREG epiregulin
EVL Enah/Vasp-like
GABPB1 GA binding protein transcription factor, beta subunit 1
GLUL glutamate-ammonia ligase
GRB7 growth factor receptor-bound protein 7
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGB2 high mobility group box 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ISOC1 isochorismatase domain containing 1
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LGALS2 lectin, galactoside-binding, soluble, 2
LPAR1 lysophosphatidic acid receptor 1
MECOM MDS1 and EVI1 complex locus
MT1E metallothionein 1E
NEK2 NIMA-related kinase 2
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PBK PDZ binding kinase
POSTN periostin, osteoblast specific factor
PRKCD protein kinase C, delta
PSD3 pleckstrin and Sec7 domain containing 3
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB25 RAB25, member RAS oncogene family
SDC2 syndecan 2
SFRP1 secreted frizzled-related protein 1
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMAD1 SMAD family member 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
STK26 serine/threonine protein kinase 26
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
UBL3 ubiquitin-like 3
WEE1 WEE1 G2 checkpoint kinase
WFDC2 WAP four-disulfide core domain 2