BRD-U70626184_BI-2536_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-U70626184_BI-2536_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5AP arachidonate 5-lipoxygenase-activating protein
CAPN2 calpain 2, (m/II) large subunit
CCL19 chemokine (C-C motif) ligand 19
CD69 CD69 molecule
CDC25A cell division cycle 25A
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
COL3A1 collagen, type III, alpha 1
CXCL13 chemokine (C-X-C motif) ligand 13
GRWD1 glutamate-rich WD repeat containing 1
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HIST1H2BK histone cluster 1, H2bk
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOPX HOP homeobox
HP haptoglobin
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
KRT17 keratin 17, type I
LTF lactotransferrin
LUM lumican
MMP9 matrix metallopeptidase 9
MNDA myeloid cell nuclear differentiation antigen
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NAMPT nicotinamide phosphoribosyltransferase
NNMT nicotinamide N-methyltransferase
PDZK1 PDZ domain containing 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLK2 polo-like kinase 2
PPIC peptidylprolyl isomerase C (cyclophilin C)
PTGES prostaglandin E synthase
RHOB ras homolog family member B
S100A12 S100 calcium binding protein A12
S100A4 S100 calcium binding protein A4
SCP2 sterol carrier protein 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLPI secretory leukocyte peptidase inhibitor
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRGN serglycin
SUB1 SUB1 homolog (S. cerevisiae)
TCAF1 TRPM8 channel-associated factor 1
TDO2 tryptophan 2,3-dioxygenase
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UGCG UDP-glucose ceramide glucosyltransferase
VDAC1 voltage-dependent anion channel 1
XIST X inactive specific transcript (non-protein coding)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreased expression

Symbol Name
APOE apolipoprotein E
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLK1 delta-like 1 homolog (Drosophila)
GPX2 glutathione peroxidase 2
GREM1 gremlin 1, DAN family BMP antagonist
HEPH hephaestin
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IGSF3 immunoglobulin superfamily, member 3
KRT7 keratin 7, type II
LIG1 ligase I, DNA, ATP-dependent
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR1H2 nuclear receptor subfamily 1, group H, member 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PPOX protoporphyrinogen oxidase
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRRM2 serine/arginine repetitive matrix 2
TMEM123 transmembrane protein 123
TOB1 transducer of ERBB2, 1