BRD-U70626184_BI-2536_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-U70626184_BI-2536_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5 arachidonate 5-lipoxygenase
ANXA4 annexin A4
BST2 bone marrow stromal cell antigen 2
CD200 CD200 molecule
CD24 CD24 molecule
CD52 CD52 molecule
CDC27 cell division cycle 27
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CETN2 centrin, EF-hand protein, 2
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNTT DNA nucleotidylexotransferase
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EZR ezrin
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FXYD2 FXYD domain containing ion transport regulator 2
GDF15 growth differentiation factor 15
GPNMB glycoprotein (transmembrane) nmb
GSTO1 glutathione S-transferase omega 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IL32 interleukin 32
JUND jun D proto-oncogene
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LXN latexin
MBNL2 muscleblind-like splicing regulator 2
METTL7A methyltransferase like 7A
MID1IP1 MID1 interacting protein 1
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
MXRA5 matrix-remodelling associated 5
NFE2 nuclear factor, erythroid 2
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PROM1 prominin 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RPS4Y1 ribosomal protein S4, Y-linked 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRGN serglycin
STAT1 signal transducer and activator of transcription 1, 91kDa
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TSPAN13 tetraspanin 13
TYROBP TYRO protein tyrosine kinase binding protein
VAMP8 vesicle-associated membrane protein 8

decreased expression

Symbol Name
BID BH3 interacting domain death agonist
BIN1 bridging integrator 1
C1ORF106 chromosome 1 open reading frame 106
CADM1 cell adhesion molecule 1
CALCA calcitonin-related polypeptide alpha
CCND1 cyclin D1
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL9A3 collagen, type IX, alpha 3
CRELD2 cysteine-rich with EGF-like domains 2
CYTL1 cytokine-like 1
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHA3 EPH receptor A3
FABP4 fatty acid binding protein 4, adipocyte
FBXL12 F-box and leucine-rich repeat protein 12
GPM6A glycoprotein M6A
IRS2 insulin receptor substrate 2
ITM2A integral membrane protein 2A
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KRT5 keratin 5, type II
MAP1B microtubule-associated protein 1B
MT1X metallothionein 1X
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NID1 nidogen 1
NOSIP nitric oxide synthase interacting protein
POSTN periostin, osteoblast specific factor
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKCA protein kinase C, alpha
RAB4A RAB4A, member RAS oncogene family
SCG2 secretogranin II
SFRP1 secreted frizzled-related protein 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
ZIC1 Zic family member 1