BRD-U68942961_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

163 genes differentially expressed following the BRD-U68942961_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ACSL3 acyl-CoA synthetase long-chain family member 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALB albumin
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
AREG amphiregulin
ASPH aspartate beta-hydroxylase
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHLHE40 basic helix-loop-helix family, member e40
BTG2 BTG family, member 2
C6ORF48 chromosome 6 open reading frame 48
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CD36 CD36 molecule (thrombospondin receptor)
CDKN2A cyclin-dependent kinase inhibitor 2A
CFB complement factor B
CPD carboxypeptidase D
CXCL13 chemokine (C-X-C motif) ligand 13
DCLK1 doublecortin-like kinase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DLK1 delta-like 1 homolog (Drosophila)
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EIF4A2 eukaryotic translation initiation factor 4A2
EREG epiregulin
FASN fatty acid synthase
FNDC3B fibronectin type III domain containing 3B
G0S2 G0/G1 switch 2
GAGE3 G antigen 3
GSAP gamma-secretase activating protein
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HOOK2 hook microtubule-tethering protein 2
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
KLF6 Kruppel-like factor 6
LDLR low density lipoprotein receptor
LOC399491
LTF lactotransferrin
LY6E lymphocyte antigen 6 complex, locus E
MCL1 myeloid cell leukemia 1
MGLL monoglyceride lipase
MLPH melanophilin
MX2 MX dynamin-like GTPase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
PDPK1 3-phosphoinositide dependent protein kinase 1
PILRB paired immunoglobin-like type 2 receptor beta
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS21 protease, serine, 21 (testisin)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RRAGC Ras-related GTP binding C
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFRP1 secreted frizzled-related protein 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A1 solute carrier family 38, member 1
SOD2 superoxide dismutase 2, mitochondrial
SRRM2 serine/arginine repetitive matrix 2
STX1A syntaxin 1A (brain)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2
TMPRSS3 transmembrane protease, serine 3
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOMM34 translocase of outer mitochondrial membrane 34
TSC22D3 TSC22 domain family, member 3
TTC3 tetratricopeptide repeat domain 3
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
XIST X inactive specific transcript (non-protein coding)
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZNF767P zinc finger family member 767, pseudogene

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AIM1 absent in melanoma 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
AXL AXL receptor tyrosine kinase
B3GNT1
C1QB complement component 1, q subcomponent, B chain
CCDC86 coiled-coil domain containing 86
CCNE2 cyclin E2
CD14 CD14 molecule
CD53 CD53 molecule
CD81 CD81 molecule
CD99 CD99 molecule
CDC25A cell division cycle 25A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHPT1 choline phosphotransferase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DPYSL2 dihydropyrimidinase-like 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
EIF5A eukaryotic translation initiation factor 5A
EXOSC4 exosome component 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GLRX2 glutaredoxin 2
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial
GSTP1 glutathione S-transferase pi 1
HSPA1A heat shock 70kDa protein 1A
IL1R2 interleukin 1 receptor, type II
KCTD12 potassium channel tetramerization domain containing 12
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIF14 kinesin family member 14
LAPTM5 lysosomal protein transmembrane 5
LMO2 LIM domain only 2 (rhombotin-like 1)
LPAR6 lysophosphatidic acid receptor 6
MKNK1 MAP kinase interacting serine/threonine kinase 1
MRPL16 mitochondrial ribosomal protein L16
MRPL57 mitochondrial ribosomal protein L57
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F2 nuclear receptor subfamily 2, group F, member 2
NT5DC2 5'-nucleotidase domain containing 2
PARP1 poly (ADP-ribose) polymerase 1
PEBP1 phosphatidylethanolamine binding protein 1
PI3 peptidase inhibitor 3, skin-derived
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PXDN peroxidasin
RAB31 RAB31, member RAS oncogene family
RAD51C RAD51 paralog C
REG1A regenerating islet-derived 1 alpha
RHOBTB3 Rho-related BTB domain containing 3
RPP38 ribonuclease P/MRP 38kDa subunit
RPS4Y1 ribosomal protein S4, Y-linked 1
SACS sacsin molecular chaperone
SASH3 SAM and SH3 domain containing 3
SORD sorbitol dehydrogenase
STAB1 stabilin 1
TUBB4B tubulin, beta 4B class IVb