BRD-U64521890_XMD16-144_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-U64521890_XMD16-144_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDOC aldolase C, fructose-bisphosphate
AQP3 aquaporin 3 (Gill blood group)
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD36 CD36 molecule (thrombospondin receptor)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTBP2 C-terminal binding protein 2
DAAM2 dishevelled associated activator of morphogenesis 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EDNRB endothelin receptor type B
EFNB2 ephrin-B2
GAS2L1 growth arrest-specific 2 like 1
GPM6B glycoprotein M6B
HIST3H2A histone cluster 3, H2a
HOPX HOP homeobox
HOXC6 homeobox C6
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
KDM3A lysine (K)-specific demethylase 3A
KIF20A kinesin family member 20A
MAGED1 melanoma antigen family D1
MAP7 microtubule-associated protein 7
MOXD1 monooxygenase, DBH-like 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
OSR2 odd-skipped related transciption factor 2
PDZRN3 PDZ domain containing ring finger 3
PLEKHA5 pleckstrin homology domain containing, family A member 5
PYGL phosphorylase, glycogen, liver
RAMP1 receptor (G protein-coupled) activity modifying protein 1
SFTPA2 surfactant protein A2
SFTPC surfactant protein C
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC16A6 solute carrier family 16, member 6
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SORT1 sortilin 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRGN serglycin
TBC1D31 TBC1 domain family, member 31
TBX2 T-box 2
TBX3 T-box 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
TOX3 TOX high mobility group box family member 3
WBP5 WW domain binding protein 5

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA1 annexin A1
ANXA3 annexin A3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BANF1 barrier to autointegration factor 1
BIRC3 baculoviral IAP repeat containing 3
C3 complement component 3
C8ORF4 chromosome 8 open reading frame 4
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN1 calpain 1, (mu/I) large subunit
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAV2 caveolin 2
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CFB complement factor B
CFI complement factor I
CHRDL1 chordin-like 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLDN1 claudin 1
CLU clusterin
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DHRS3 dehydrogenase/reductase (SDR family) member 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
FHL2 four and a half LIM domains 2
FLNB filamin B, beta
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GHR growth hormone receptor
GPX3 glutathione peroxidase 3
GRIA2 glutamate receptor, ionotropic, AMPA 2
HCAR3 hydroxycarboxylic acid receptor 3
HLF hepatic leukemia factor
IFRD2 interferon-related developmental regulator 2
IL32 interleukin 32
IRF1 interferon regulatory factor 1
ITM2A integral membrane protein 2A
KRT13 keratin 13, type I
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT4 keratin 4, type II
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LCN2 lipocalin 2
MEIS2 Meis homeobox 2
MGP matrix Gla protein
MUC1 mucin 1, cell surface associated
MUC16 mucin 16, cell surface associated
MXRA5 matrix-remodelling associated 5
NELL2 NEL-like 2 (chicken)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F6 nuclear receptor subfamily 2, group F, member 6
OLFM4 olfactomedin 4
PENK proenkephalin
PIP prolactin-induced protein
PLAC8 placenta-specific 8
PNMA2 paraneoplastic Ma antigen 2
PRKCD protein kinase C, delta
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBP4 retinol binding protein 4, plasma
RCAN1 regulator of calcineurin 1
RND3 Rho family GTPase 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SOX4 SRY (sex determining region Y)-box 4
STK32B serine/threonine kinase 32B
SYNGR3 synaptogyrin 3
TACSTD2 tumor-associated calcium signal transducer 2
TCF4 transcription factor 4
TF transferrin
TFPI2 tissue factor pathway inhibitor 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIM29 tripartite motif containing 29
TSPAN4 tetraspanin 4
VGLL1 vestigial-like family member 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2
XIST X inactive specific transcript (non-protein coding)
ZBED2 zinc finger, BED-type containing 2