BRD-U64521890_XMD16-144_MDAMB231_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-U64521890_XMD16-144_MDAMB231_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AK1 adenylate kinase 1
ASRGL1 asparaginase like 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CENPU centromere protein U
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DDIT4 DNA-damage-inducible transcript 4
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
EMP2 epithelial membrane protein 2
FLG filaggrin
GAS1 growth arrest-specific 1
GDF15 growth differentiation factor 15
GOLGA8A golgin A8 family, member A
GPNMB glycoprotein (transmembrane) nmb
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSDL2 hydroxysteroid dehydrogenase like 2
IDE insulin-degrading enzyme
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KCTD5 potassium channel tetramerization domain containing 5
MATN2 matrilin 2
MTUS1 microtubule associated tumor suppressor 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX3 pre-B-cell leukemia homeobox 3
PDGFA platelet-derived growth factor alpha polypeptide
PERP PERP, TP53 apoptosis effector
PLAGL1 pleiomorphic adenoma gene-like 1
PPP1R13B protein phosphatase 1, regulatory subunit 13B
RNH1 ribonuclease/angiogenin inhibitor 1
RPS11 ribosomal protein S11
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SIK1 salt-inducible kinase 1
SKAP2 src kinase associated phosphoprotein 2
SULF1 sulfatase 1
SYBU syntabulin (syntaxin-interacting)
TSC22D3 TSC22 domain family, member 3

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADRB2 adrenoceptor beta 2, surface
ANGPT1 angiopoietin 1
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BMP4 bone morphogenetic protein 4
CD24 CD24 molecule
CES2 carboxylesterase 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYTL1 cytokine-like 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F13A1 coagulation factor XIII, A1 polypeptide
FOSL2 FOS-like antigen 2
FRZB frizzled-related protein
FST follistatin
GBP1 guanylate binding protein 1, interferon-inducible
HAS2 hyaluronan synthase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
KDM5D lysine (K)-specific demethylase 5D
KRT4 keratin 4, type II
MARCKS myristoylated alanine-rich protein kinase C substrate
PROM1 prominin 1
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RNF167 ring finger protein 167
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A9 S100 calcium binding protein A9
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLIT2 slit homolog 2 (Drosophila)
SNAI2 snail family zinc finger 2
SPP1 secreted phosphoprotein 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TKTL1 transketolase-like 1
VCAN versican