BRD-U64521890_XMD16-144_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-U64521890_XMD16-144_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ALB albumin
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ALDOB aldolase B, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
APOB apolipoprotein B
APOH apolipoprotein H (beta-2-glycoprotein I)
BEX1 brain expressed, X-linked 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CD52 CD52 molecule
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
CXCR4 chemokine (C-X-C motif) receptor 4
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DSP desmoplakin
FUCA1 fucosidase, alpha-L- 1, tissue
GPX1 glutathione peroxidase 1
GSTA1 glutathione S-transferase alpha 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
ITGA6 integrin, alpha 6
KDM3A lysine (K)-specific demethylase 3A
LGMN legumain
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN2B1 mannosidase, alpha, class 2B, member 1
MAOA monoamine oxidase A
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG10 paternally expressed 10
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PRAF2 PRA1 domain family, member 2
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SESN1 sestrin 1
SSR4 signal sequence receptor, delta
SST somatostatin
STXBP1 syntaxin binding protein 1
TMEM2 transmembrane protein 2
VAMP8 vesicle-associated membrane protein 8
ZDHHC11 zinc finger, DHHC-type containing 11
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
BRCA1 breast cancer 1, early onset
CA2 carbonic anhydrase II
CAPN1 calpain 1, (mu/I) large subunit
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CCNE2 cyclin E2
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
CHEK1 checkpoint kinase 1
COL5A1 collagen, type V, alpha 1
DEPTOR DEP domain containing MTOR-interacting protein
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EGR3 early growth response 3
EREG epiregulin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HOMER3 homer scaffolding protein 3
IFITM1 interferon induced transmembrane protein 1
IGL immunoglobulin lambda locus
KRT23 keratin 23, type I
LMNB1 lamin B1
LOXL1 lysyl oxidase-like 1
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MCTP1 multiple C2 domains, transmembrane 1
MUC1 mucin 1, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
PIP prolactin-induced protein
PLBD1 phospholipase B domain containing 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAP2C phosphatidic acid phosphatase type 2C
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PYCR1 pyrroline-5-carboxylate reductase 1
RFC3 replication factor C (activator 1) 3, 38kDa
RGS2 regulator of G-protein signaling 2
RRM1 ribonucleotide reductase M1
S100A2 S100 calcium binding protein A2
S100A9 S100 calcium binding protein A9
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SPARCL1 SPARC-like 1 (hevin)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TYMS thymidylate synthetase