BRD-U64521890_XMD16-144_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

127 genes differentially expressed following the BRD-U64521890_XMD16-144_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AKAP8L A kinase (PRKA) anchor protein 8-like
COL4A5 collagen, type IV, alpha 5
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FHL1 four and a half LIM domains 1
FOXD1 forkhead box D1
GOLGA8H golgin A8 family, member H
GSTM3 glutathione S-transferase mu 3 (brain)
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HIST3H2A histone cluster 3, H2a
IFI6 interferon, alpha-inducible protein 6
ISG15 ISG15 ubiquitin-like modifier
ITGAV integrin, alpha V
LDOC1 leucine zipper, down-regulated in cancer 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
N4BP2L2 NEDD4 binding protein 2-like 2
NQO1 NAD(P)H dehydrogenase, quinone 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPP1R13B protein phosphatase 1, regulatory subunit 13B
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
STK10 serine/threonine kinase 10
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ABLIM1 actin binding LIM protein 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AIM1 absent in melanoma 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA1 annexin A1
ARL4C ADP-ribosylation factor-like 4C
ASPN asporin
C3 complement component 3
CA2 carbonic anhydrase II
CCL2 chemokine (C-C motif) ligand 2
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COL15A1 collagen, type XV, alpha 1
COL3A1 collagen, type III, alpha 1
COL8A2 collagen, type VIII, alpha 2
CPA3 carboxypeptidase A3 (mast cell)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
DCN decorin
DLK1 delta-like 1 homolog (Drosophila)
DTX4 deltex 4, E3 ubiquitin ligase
EIF5 eukaryotic translation initiation factor 5
EMP1 epithelial membrane protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FBLN1 fibulin 1
FGFR1 fibroblast growth factor receptor 1
FSTL1 follistatin-like 1
GAL galanin/GMAP prepropeptide
GLUL glutamate-ammonia ligase
HBB hemoglobin, beta
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP3 insulin-like growth factor binding protein 3
JCHAIN joining chain of multimeric IgA and IgM
KRT6B keratin 6B, type II
LEF1 lymphoid enhancer-binding factor 1
LPAR1 lysophosphatidic acid receptor 1
LUM lumican
LXN latexin
LYZ lysozyme
MAPK13 mitogen-activated protein kinase 13
MCM4 minichromosome maintenance complex component 4
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MSH6 mutS homolog 6
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MXRA5 matrix-remodelling associated 5
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
P3H2 prolyl 3-hydroxylase 2
PCOLCE procollagen C-endopeptidase enhancer
PLAC8 placenta-specific 8
PLIN2 perilipin 2
PLS3 plastin 3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
POU2AF1 POU class 2 associating factor 1
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PYCR1 pyrroline-5-carboxylate reductase 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAD51AP1 RAD51 associated protein 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SAMD4A sterile alpha motif domain containing 4A
SCEL sciellin
SDC1 syndecan 1
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPRY2 sprouty homolog 2 (Drosophila)
TGM2 transglutaminase 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSPAN8 tetraspanin 8
TUBB2A tubulin, beta 2A class IIa
VSNL1 visinin-like 1
WFDC1 WAP four-disulfide core domain 1