BRD-U64521890_XMD16-144_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-U64521890_XMD16-144_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASS1 argininosuccinate synthase 1
BCL2A1 BCL2-related protein A1
BEX4 brain expressed, X-linked 4
CCL20 chemokine (C-C motif) ligand 20
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLIC5 chloride intracellular channel 5
CSTA cystatin A (stefin A)
EPM2AIP1 EPM2A (laforin) interacting protein 1
ETNK1 ethanolamine kinase 1
FABP4 fatty acid binding protein 4, adipocyte
FAM134B family with sequence similarity 134, member B
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FNBP1 formin binding protein 1
FXYD3 FXYD domain containing ion transport regulator 3
GADD45A growth arrest and DNA-damage-inducible, alpha
GOLGA8A golgin A8 family, member A
H2BFS H2B histone family, member S (pseudogene)
HACD1 3-hydroxyacyl-CoA dehydratase 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HSPA4L heat shock 70kDa protein 4-like
IL13RA2 interleukin 13 receptor, alpha 2
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
N4BP2L2 NEDD4 binding protein 2-like 2
NEBL nebulette
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NXN nucleoredoxin
PLCB4 phospholipase C, beta 4
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PROM1 prominin 1
RBKS ribokinase
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPS27L ribosomal protein S27-like
SCAF4 SR-related CTD-associated factor 4
SCPEP1 serine carboxypeptidase 1
SELL selectin L
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SESN1 sestrin 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SRSF11 serine/arginine-rich splicing factor 11
TIGAR TP53 induced glycolysis regulatory phosphatase
TSPYL5 TSPY-like 5
TUBB6 tubulin, beta 6 class V

decreased expression

Symbol Name
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
ARL4C ADP-ribosylation factor-like 4C
BGN biglycan
BICC1 BicC family RNA binding protein 1
C5 complement component 5
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPG capping protein (actin filament), gelsolin-like
CAST calpastatin
CCL2 chemokine (C-C motif) ligand 2
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CFH complement factor H
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A3 collagen, type VI, alpha 3
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL9 chemokine (C-X-C motif) ligand 9
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DHRS3 dehydrogenase/reductase (SDR family) member 3
DPYD dihydropyrimidine dehydrogenase
E2F2 E2F transcription factor 2
EPAS1 endothelial PAS domain protein 1
FAM129A family with sequence similarity 129, member A
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGFR3 fibroblast growth factor receptor 3
FKBP14 FK506 binding protein 14, 22 kDa
FN1 fibronectin 1
GLUL glutamate-ammonia ligase
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
HNMT histamine N-methyltransferase
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
IL1R1 interleukin 1 receptor, type I
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCTD12 potassium channel tetramerization domain containing 12
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
LGALS3 lectin, galactoside-binding, soluble, 3
LRRC17 leucine rich repeat containing 17
LYN LYN proto-oncogene, Src family tyrosine kinase
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM4 minichromosome maintenance complex component 4
MELK maternal embryonic leucine zipper kinase
NRP1 neuropilin 1
NTS neurotensin
PDLIM5 PDZ and LIM domain 5
PLAU plasminogen activator, urokinase
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGS2 regulator of G-protein signaling 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE4 ribonuclease, RNase A family, 4
RRM2 ribonucleotide reductase M2
SEC63 SEC63 homolog (S. cerevisiae)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLIT2 slit homolog 2 (Drosophila)
SNAP25 synaptosomal-associated protein, 25kDa
SPATS2L spermatogenesis associated, serine-rich 2-like
TF transferrin
TFR2 transferrin receptor 2
TNC tenascin C
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM1 tropomyosin 1 (alpha)
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa