BRD-U64521890_XMD16-144_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-U64521890_XMD16-144_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BID BH3 interacting domain death agonist
BTG1 B-cell translocation gene 1, anti-proliferative
CADM1 cell adhesion molecule 1
CCDC92 coiled-coil domain containing 92
CD47 CD47 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES2 carboxylesterase 2
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DSP desmoplakin
FCGBP Fc fragment of IgG binding protein
FDXR ferredoxin reductase
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GLS glutaminase
GPM6B glycoprotein M6B
GSTM3 glutathione S-transferase mu 3 (brain)
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
JAK1 Janus kinase 1
KIF2C kinesin family member 2C
KRT23 keratin 23, type I
NFIB nuclear factor I/B
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
ORAI3 ORAI calcium release-activated calcium modulator 3
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PHYH phytanoyl-CoA 2-hydroxylase
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCB4 phospholipase C, beta 4
PROM1 prominin 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPS27L ribosomal protein S27-like
S100A8 S100 calcium binding protein A8
SDC2 syndecan 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SESN1 sestrin 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SOX9 SRY (sex determining region Y)-box 9
SSFA2 sperm specific antigen 2
STOM stomatin
SYBU syntabulin (syntaxin-interacting)
TFF1 trefoil factor 1
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TRPS1 trichorhinophalangeal syndrome I
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VAT1 vesicle amine transport 1
VNN1 vanin 1
ZFP36 ZFP36 ring finger protein
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BCAT1 branched chain amino-acid transaminase 1, cytosolic
C2CD2 C2 calcium-dependent domain containing 2
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CENPN centromere protein N
CHEK1 checkpoint kinase 1
COL4A2 collagen, type IV, alpha 2
COL5A2 collagen, type V, alpha 2
CST1 cystatin SN
CXCL13 chemokine (C-X-C motif) ligand 13
CXCR4 chemokine (C-X-C motif) receptor 4
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCK deoxycytidine kinase
DUT deoxyuridine triphosphatase
E2F2 E2F transcription factor 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM129A family with sequence similarity 129, member A
FEN1 flap structure-specific endonuclease 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GINS1 GINS complex subunit 1 (Psf1 homolog)
GSTP1 glutathione S-transferase pi 1
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
KIAA0101 KIAA0101
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYLK myosin light chain kinase
NME4 NME/NM23 nucleoside diphosphate kinase 4
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PLBD1 phospholipase B domain containing 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSPH phosphoserine phosphatase
PYCR1 pyrroline-5-carboxylate reductase 1
RAD51AP1 RAD51 associated protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
SORBS3 sorbin and SH3 domain containing 3
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TCF3 transcription factor 3
TIPIN TIMELESS interacting protein
TNS1 tensin 1