BRD-U64521890_XMD16-144_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-U64521890_XMD16-144_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADRB2 adrenoceptor beta 2, surface
AK1 adenylate kinase 1
APOE apolipoprotein E
ASS1 argininosuccinate synthase 1
BAX BCL2-associated X protein
C6ORF62 chromosome 6 open reading frame 62
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEMIP cell migration inducing protein, hyaluronan binding
COBL cordon-bleu WH2 repeat protein
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
COL6A3 collagen, type VI, alpha 3
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DLC1 DLC1 Rho GTPase activating protein
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FGFR4 fibroblast growth factor receptor 4
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GPX2 glutathione peroxidase 2
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IL6 interleukin 6
INHBA inhibin, beta A
KAZN kazrin, periplakin interacting protein
KIF20A kinesin family member 20A
KLF4 Kruppel-like factor 4 (gut)
KRT17 keratin 17, type I
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LYZ lysozyme
MTSS1 metastasis suppressor 1
NARFL nuclear prelamin A recognition factor-like
NOTCH1 notch 1
PDGFC platelet derived growth factor C
PHLDA3 pleckstrin homology-like domain, family A, member 3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTGDS prostaglandin D2 synthase 21kDa (brain)
RPS27L ribosomal protein S27-like
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SESN1 sestrin 1
SGK1 serum/glucocorticoid regulated kinase 1
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TAGLN transgelin
TFF3 trefoil factor 3 (intestinal)
TOB1 transducer of ERBB2, 1
TRIM22 tripartite motif containing 22
WFDC1 WAP four-disulfide core domain 1
WIF1 WNT inhibitory factor 1
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
BEX4 brain expressed, X-linked 4
CAST calpastatin
CCNE2 cyclin E2
CD9 CD9 molecule
CREB1 cAMP responsive element binding protein 1
CTTN cortactin
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLV2-23 immunoglobulin lambda variable 2-23
IL13RA2 interleukin 13 receptor, alpha 2
LAPTM4B lysosomal protein transmembrane 4 beta
LPCAT1 lysophosphatidylcholine acyltransferase 1
MGP matrix Gla protein
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
NPY1R neuropeptide Y receptor Y1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
RAB38 RAB38, member RAS oncogene family
REG1A regenerating islet-derived 1 alpha
SHOX2 short stature homeobox 2
SLC43A3 solute carrier family 43, member 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TPBG trophoblast glycoprotein
TRIB2 tribbles pseudokinase 2
USP6NL USP6 N-terminal like
WBP5 WW domain binding protein 5
ZFP36L1 ZFP36 ring finger protein-like 1
ZIC1 Zic family member 1