BRD-U61997977_WZ-4-145_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

230 genes differentially expressed following the BRD-U61997977_WZ-4-145_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACADVL acyl-CoA dehydrogenase, very long chain
AIF1 allograft inflammatory factor 1
ANXA11 annexin A11
ARMCX3 armadillo repeat containing, X-linked 3
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
BEX4 brain expressed, X-linked 4
BTG1 B-cell translocation gene 1, anti-proliferative
C1ORF106 chromosome 1 open reading frame 106
CAPN1 calpain 1, (mu/I) large subunit
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
CFD complement factor D (adipsin)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN10 claudin 10
CLDN3 claudin 3
CLDN4 claudin 4
CLIC5 chloride intracellular channel 5
CPM carboxypeptidase M
CRABP2 cellular retinoic acid binding protein 2
CTSL cathepsin L
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DRAM1 DNA-damage regulated autophagy modulator 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EXPH5 exophilin 5
FAM63A family with sequence similarity 63, member A
FLG filaggrin
FOXO3 forkhead box O3
GAS1 growth arrest-specific 1
GAS6 growth arrest-specific 6
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
HIST1H2BD histone cluster 1, H2bd
HLA-E major histocompatibility complex, class I, E
HNMT histamine N-methyltransferase
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSPA2 heat shock 70kDa protein 2
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
KRT23 keratin 23, type I
LAMP2 lysosomal-associated membrane protein 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LXN latexin
MACROD1 MACRO domain containing 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL2 muscleblind-like splicing regulator 2
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYLIP myosin regulatory light chain interacting protein
MYO1D myosin ID
NCK2 NCK adaptor protein 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NET1 neuroepithelial cell transforming 1
NPIPB3 nuclear pore complex interacting protein family, member B3
OBSL1 obscurin-like 1
OPN3 opsin 3
OSBPL1A oxysterol binding protein-like 1A
PLAGL1 pleiomorphic adenoma gene-like 1
PLIN2 perilipin 2
PRAME preferentially expressed antigen in melanoma
PRSS8 protease, serine, 8
QPRT quinolinate phosphoribosyltransferase
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RTN2 reticulon 2
S100A4 S100 calcium binding protein A4
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SLC22A18 solute carrier family 22, member 18
SLC35E2B solute carrier family 35, member E2B
SLC38A2 solute carrier family 38, member 2
SPATA20 spermatogenesis associated 20
STK38 serine/threonine kinase 38
TCEAL4 transcription elongation factor A (SII)-like 4
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TIMP2 TIMP metallopeptidase inhibitor 2
TMEM63A transmembrane protein 63A
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UBQLN2 ubiquilin 2
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WDR45 WD repeat domain 45
WFDC2 WAP four-disulfide core domain 2
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
C20ORF27 chromosome 20 open reading frame 27
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CCND2 cyclin D2
CCNF cyclin F
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKLF chemokine-like factor
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL13 chemokine (C-X-C motif) ligand 13
DCK deoxycytidine kinase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EGR1 early growth response 1
EIF4E eukaryotic translation initiation factor 4E
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAS Fas cell surface death receptor
FASN fatty acid synthase
FGFR3 fibroblast growth factor receptor 3
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAS GNAS complex locus
GPX3 glutathione peroxidase 3
GRIA2 glutamate receptor, ionotropic, AMPA 2
GTSE1 G-2 and S-phase expressed 1
HJURP Holliday junction recognition protein
HMMR hyaluronan-mediated motility receptor (RHAMM)
IGHD immunoglobulin heavy constant delta
IL1R2 interleukin 1 receptor, type II
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITGB1BP1 integrin beta 1 binding protein 1
KIAA0101 KIAA0101
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KRT16 keratin 16, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LBR lamin B receptor
LMO3 LIM domain only 3 (rhombotin-like 2)
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MCM4 minichromosome maintenance complex component 4
MCM7 minichromosome maintenance complex component 7
MKI67 marker of proliferation Ki-67
MT1E metallothionein 1E
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
ODC1 ornithine decarboxylase 1
P3H2 prolyl 3-hydroxylase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PEG10 paternally expressed 10
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTRF polymerase I and transcript release factor
PTTG1 pituitary tumor-transforming 1
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SHCBP1 SHC SH2-domain binding protein 1
SIVA1 SIVA1, apoptosis-inducing factor
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SMC4 structural maintenance of chromosomes 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SPC25 SPC25, NDC80 kinetochore complex component
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRM spermidine synthase
SRSF3 serine/arginine-rich splicing factor 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TCL1A T-cell leukemia/lymphoma 1A
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM14A transmembrane protein 14A
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein