BRD-U61997977_WZ-4-145_MCF10A_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-U61997977_WZ-4-145_MCF10A_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG1 adhesion G protein-coupled receptor G1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
ANXA11 annexin A11
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ASS1 argininosuccinate synthase 1
BASP1 brain abundant, membrane attached signal protein 1
BTG1 B-cell translocation gene 1, anti-proliferative
C14ORF132 chromosome 14 open reading frame 132
C1ORF106 chromosome 1 open reading frame 106
CAPN1 calpain 1, (mu/I) large subunit
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CFD complement factor D (adipsin)
CHRDL1 chordin-like 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLDN3 claudin 3
CLDN7 claudin 7
CLIC5 chloride intracellular channel 5
CP ceruloplasmin (ferroxidase)
CRYAB crystallin, alpha B
CSTA cystatin A (stefin A)
CTBP2 C-terminal binding protein 2
CTSK cathepsin K
CXCL12 chemokine (C-X-C motif) ligand 12
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
EFNA1 ephrin-A1
EIF3F eukaryotic translation initiation factor 3, subunit F
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPS8L2 EPS8-like 2
ESRP1 epithelial splicing regulatory protein 1
FBLN1 fibulin 1
FBLN2 fibulin 2
FBLN5 fibulin 5
GAS1 growth arrest-specific 1
GLUL glutamate-ammonia ligase
GRN granulin
GSN gelsolin
HIST3H2A histone cluster 3, H2a
HMGN3 high mobility group nucleosomal binding domain 3
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSPB1 heat shock 27kDa protein 1
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IL1B interleukin 1, beta
IRS2 insulin receptor substrate 2
ITGB4 integrin, beta 4
KRT19 keratin 19, type I
LCN2 lipocalin 2
LDHB lactate dehydrogenase B
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LXN latexin
MFAP5 microfibrillar associated protein 5
MGLL monoglyceride lipase
MME membrane metallo-endopeptidase
MUC1 mucin 1, cell surface associated
MYL9 myosin, light chain 9, regulatory
NEFH neurofilament, heavy polypeptide
OPTN optineurin
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1IP1 PDZK1 interacting protein 1
PERP PERP, TP53 apoptosis effector
PEX11A peroxisomal biogenesis factor 11 alpha
PPL periplakin
PPOX protoporphyrinogen oxidase
PRSS8 protease, serine, 8
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100A14 S100 calcium binding protein A14
S100A8 S100 calcium binding protein A8
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SH3BGRL SH3 domain binding glutamate-rich protein like
SLPI secretory leukocyte peptidase inhibitor
SORBS1 sorbin and SH3 domain containing 1
SPINT1 serine peptidase inhibitor, Kunitz type 1
TAGLN transgelin
TCEAL4 transcription elongation factor A (SII)-like 4
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMPRSS2 transmembrane protease, serine 2
TP53 tumor protein p53
TPM1 tropomyosin 1 (alpha)
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TSPAN1 tetraspanin 1
TUBB6 tubulin, beta 6 class V
TXNIP thioredoxin interacting protein
VNN1 vanin 1
WISP2 WNT1 inducible signaling pathway protein 2
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
BLMH bleomycin hydrolase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHA3 EPH receptor A3
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
HBEGF heparin-binding EGF-like growth factor
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HHEX hematopoietically expressed homeobox
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL13RA2 interleukin 13 receptor, alpha 2
IQGAP2 IQ motif containing GTPase activating protein 2
KDM5D lysine (K)-specific demethylase 5D
LMO4 LIM domain only 4
LRRC17 leucine rich repeat containing 17
NAV3 neuron navigator 3
POPDC3 popeye domain containing 3
PSPH phosphoserine phosphatase
REEP5 receptor accessory protein 5
RFC2 replication factor C (activator 1) 2, 40kDa
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS4Y1 ribosomal protein S4, Y-linked 1
SCML1 sex comb on midleg-like 1 (Drosophila)
SORD sorbitol dehydrogenase
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
TFF3 trefoil factor 3 (intestinal)
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
VCAM1 vascular cell adhesion molecule 1