BRD-U61997977_WZ-4-145_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

207 genes differentially expressed following the BRD-U61997977_WZ-4-145_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ABLIM1 actin binding LIM protein 1
ACTC1 actin, alpha, cardiac muscle 1
ADA adenosine deaminase
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOD apolipoprotein D
ARID5B AT rich interactive domain 5B (MRF1-like)
ASS1 argininosuccinate synthase 1
BID BH3 interacting domain death agonist
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFD complement factor D (adipsin)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CNN1 calponin 1, basic, smooth muscle
COL11A1 collagen, type XI, alpha 1
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CPT1A carnitine palmitoyltransferase 1A (liver)
CRABP2 cellular retinoic acid binding protein 2
DCN decorin
DDR1 discoidin domain receptor tyrosine kinase 1
ENO2 enolase 2 (gamma, neuronal)
ERBB2 erb-b2 receptor tyrosine kinase 2
FADS1 fatty acid desaturase 1
FADS3 fatty acid desaturase 3
FBLN1 fibulin 1
FTH1 ferritin, heavy polypeptide 1
GUSBP11 glucuronidase, beta pseudogene 11
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
ITGB4 integrin, beta 4
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JCHAIN joining chain of multimeric IgA and IgM
KIAA1033 KIAA1033
KIZ kizuna centrosomal protein
KLHL24 kelch-like family member 24
LAMP2 lysosomal-associated membrane protein 2
LMOD1 leiomodin 1 (smooth muscle)
LXN latexin
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MBNL2 muscleblind-like splicing regulator 2
MDK midkine (neurite growth-promoting factor 2)
MFAP5 microfibrillar associated protein 5
MFGE8 milk fat globule-EGF factor 8 protein
MKRN1 makorin ring finger protein 1
MME membrane metallo-endopeptidase
MYH10 myosin, heavy chain 10, non-muscle
NNMT nicotinamide N-methyltransferase
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
ORAI3 ORAI calcium release-activated calcium modulator 3
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PAWR PRKC, apoptosis, WT1, regulator
PLIN2 perilipin 2
PLXND1 plexin D1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RHOQ ras homolog family member Q
RRAGD Ras-related GTP binding D
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFRP4 secreted frizzled-related protein 4
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3YL1 SH3 and SYLF domain containing 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SOX4 SRY (sex determining region Y)-box 4
SPAG4 sperm associated antigen 4
TNS1 tensin 1
VAT1 vesicle amine transport 1
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARPC5L actin related protein 2/3 complex, subunit 5-like
ASF1B anti-silencing function 1B histone chaperone
ASPH aspartate beta-hydroxylase
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BMP2 bone morphogenetic protein 2
BRCA1 breast cancer 1, early onset
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CD69 CD69 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CEP55 centrosomal protein 55kDa
CKS1B CDC28 protein kinase regulatory subunit 1B
COL1A2 collagen, type I, alpha 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHFR dihydrofolate reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
DUT deoxyuridine triphosphatase
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMP1 epithelial membrane protein 1
EREG epiregulin
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FANCI Fanconi anemia, complementation group I
FBN2 fibrillin 2
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HHEX hematopoietically expressed homeobox
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HOPX HOP homeobox
IFRD2 interferon-related developmental regulator 2
JUN jun proto-oncogene
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIAA0101 KIAA0101
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF4A kinesin family member 4A
LIG1 ligase I, DNA, ATP-dependent
LPAR1 lysophosphatidic acid receptor 1
MAP7 microtubule-associated protein 7
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NEK2 NIMA-related kinase 2
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NPTX2 neuronal pentraxin II
NUP62 nucleoporin 62kDa
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
PITX1 paired-like homeodomain 1
PNP purine nucleoside phosphorylase
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RANBP1 RAN binding protein 1
RECQL RecQ helicase-like
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUVBL2 RuvB-like AAA ATPase 2
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPATS2L spermatogenesis associated, serine-rich 2-like
SPC25 SPC25, NDC80 kinetochore complex component
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
STRA13 stimulated by retinoic acid 13
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TFPI2 tissue factor pathway inhibitor 2
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TM4SF1 transmembrane 4 L six family member 1
TMEM97 transmembrane protein 97
TNC tenascin C
TRIP13 thyroid hormone receptor interactor 13
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
ZWINT ZW10 interacting kinetochore protein