BRD-U61997977_WZ-4-145_HS578T_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

157 genes differentially expressed following the BRD-U61997977_WZ-4-145_HS578T_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTC1 actin, alpha, cardiac muscle 1
ADIRF adipogenesis regulatory factor
AMIGO2 adhesion molecule with Ig-like domain 2
APOD apolipoprotein D
ARG2 arginase 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ASS1 argininosuccinate synthase 1
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BEX1 brain expressed, X-linked 1
BTG2 BTG family, member 2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFB complement factor B
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTGF connective tissue growth factor
DCN decorin
DPYSL3 dihydropyrimidinase-like 3
DSTN destrin (actin depolymerizing factor)
EAPP E2F-associated phosphoprotein
EHD3 EH-domain containing 3
EPS8L2 EPS8-like 2
ERBB4 erb-b2 receptor tyrosine kinase 4
FADS3 fatty acid desaturase 3
FILIP1L filamin A interacting protein 1-like
FLRT3 fibronectin leucine rich transmembrane protein 3
GATA3 GATA binding protein 3
GLS glutaminase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HIST1H2AC histone cluster 1, H2ac
IDS iduronate 2-sulfatase
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
INHBA inhibin, beta A
ISG15 ISG15 ubiquitin-like modifier
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
IVNS1ABP influenza virus NS1A binding protein
KIF5C kinesin family member 5C
KLF13 Kruppel-like factor 13
KRAS Kirsten rat sarcoma viral oncogene homolog
LRRC15 leucine rich repeat containing 15
LUM lumican
LXN latexin
MFAP5 microfibrillar associated protein 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MTSS1 metastasis suppressor 1
MYO1D myosin ID
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NNMT nicotinamide N-methyltransferase
NOV nephroblastoma overexpressed
NXN nucleoredoxin
PAWR PRKC, apoptosis, WT1, regulator
PCP4 Purkinje cell protein 4
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PNRC1 proline-rich nuclear receptor coactivator 1
PSAT1 phosphoserine aminotransferase 1
PTGIS prostaglandin I2 (prostacyclin) synthase
PYCARD PYD and CARD domain containing
QPCT glutaminyl-peptide cyclotransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB21 RAB21, member RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SIRT3 sirtuin 3
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A1 solute carrier family 38, member 1
SPTSSA serine palmitoyltransferase, small subunit A
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SULF1 sulfatase 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TLR4 toll-like receptor 4
TPD52L1 tumor protein D52-like 1
TRAF5 TNF receptor-associated factor 5
TXNIP thioredoxin interacting protein
VCAN versican
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASF1B anti-silencing function 1B histone chaperone
ASPH aspartate beta-hydroxylase
ATAD2 ATPase family, AAA domain containing 2
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDCP1 CUB domain containing protein 1
CDK1 cyclin-dependent kinase 1
CHN1 chimerin 1
COL15A1 collagen, type XV, alpha 1
CRISP3 cysteine-rich secretory protein 3
CXCL8 chemokine (C-X-C motif) ligand 8
DCK deoxycytidine kinase
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
DST dystonin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EGFR epidermal growth factor receptor
EPS8 epidermal growth factor receptor pathway substrate 8
ETV1 ets variant 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GOLGA8H golgin A8 family, member H
H2AFX H2A histone family, member X
HHEX hematopoietically expressed homeobox
IFRD2 interferon-related developmental regulator 2
LIG1 ligase I, DNA, ATP-dependent
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCAPH non-SMC condensin I complex, subunit H
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRP1 neuropilin 1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PITX1 paired-like homeodomain 1
PRC1 protein regulator of cytokinesis 1
RACGAP1 Rac GTPase activating protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RRM2 ribonucleotide reductase M2
SFRP1 secreted frizzled-related protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMAD3 SMAD family member 3
SMC4 structural maintenance of chromosomes 4
SOBP sine oculis binding protein homolog (Drosophila)
SPARCL1 SPARC-like 1 (hevin)
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
SRSF7 serine/arginine-rich splicing factor 7
STC1 stanniocalcin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIP13 thyroid hormone receptor interactor 13
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1