BRD-U61997977_WZ-4-145_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-U61997977_WZ-4-145_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDOC aldolase C, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BEX4 brain expressed, X-linked 4
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CES1 carboxylesterase 1
CFB complement factor B
CPVL carboxypeptidase, vitellogenic-like
CREG1 cellular repressor of E1A-stimulated genes 1
CTSA cathepsin A
CTSD cathepsin D
CYBRD1 cytochrome b reductase 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DKK3 dickkopf WNT signaling pathway inhibitor 3
FAM127A family with sequence similarity 127, member A
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGA fibrinogen alpha chain
FST follistatin
FTH1 ferritin, heavy polypeptide 1
GJA1 gap junction protein, alpha 1, 43kDa
GM2A GM2 ganglioside activator
GNPDA1 glucosamine-6-phosphate deaminase 1
GPC3 glypican 3
GPI glucose-6-phosphate isomerase
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GRN granulin
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IRS2 insulin receptor substrate 2
KDM3A lysine (K)-specific demethylase 3A
LBH limb bud and heart development
LEPR leptin receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LUM lumican
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1C1 mannosidase, alpha, class 1C, member 1
MAP7 microtubule-associated protein 7
MMD monocyte to macrophage differentiation-associated
MYO6 myosin VI
N4BP2L1 NEDD4 binding protein 2-like 1
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NREP neuronal regeneration related protein
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PHYH phytanoyl-CoA 2-hydroxylase
PIEZO2 piezo-type mechanosensitive ion channel component 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLIN2 perilipin 2
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2B phosphatidic acid phosphatase type 2B
PTPRK protein tyrosine phosphatase, receptor type, K
RAB38 RAB38, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RSRP1 arginine/serine-rich protein 1
SCAMP1 secretory carrier membrane protein 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
TARP TCR gamma alternate reading frame protein
TCEAL4 transcription elongation factor A (SII)-like 4
TP53 tumor protein p53
TPP1 tripeptidyl peptidase I
TPST2 tyrosylprotein sulfotransferase 2
TRAPPC6A trafficking protein particle complex 6A
TSKU tsukushi, small leucine rich proteoglycan
UGDH UDP-glucose 6-dehydrogenase
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1
VEGFA vascular endothelial growth factor A
WNK1 WNK lysine deficient protein kinase 1
XBP1 X-box binding protein 1
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ADGRE5 adhesion G protein-coupled receptor E5
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA1 annexin A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNF cyclin F
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CEP55 centrosomal protein 55kDa
CIT citron rho-interacting serine/threonine kinase
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EXOSC4 exosome component 4
FKBP14 FK506 binding protein 14, 22 kDa
FOSL1 FOS-like antigen 1
HIST1H2BG histone cluster 1, H2bg
HOPX HOP homeobox
IL1R2 interleukin 1 receptor, type II
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KLF2 Kruppel-like factor 2
LOC100505650 uncharacterized LOC100505650
LOXL1 lysyl oxidase-like 1
MKI67 marker of proliferation Ki-67
MMP10 matrix metallopeptidase 10
MYCBP MYC binding protein
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NFIB nuclear factor I/B
NIP7 NIP7, nucleolar pre-rRNA processing protein
NR2F2 nuclear receptor subfamily 2, group F, member 2
PALLD palladin, cytoskeletal associated protein
PBK PDZ binding kinase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
RCAN1 regulator of calcineurin 1
RGS2 regulator of G-protein signaling 2
RHOA ras homolog family member A
RHOB ras homolog family member B
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
SACS sacsin molecular chaperone
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SHCBP1 SHC SH2-domain binding protein 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TES testin LIM domain protein
TFF3 trefoil factor 3 (intestinal)
TGFA transforming growth factor, alpha
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSPAN5 tetraspanin 5
TXN thioredoxin
USP6NL USP6 N-terminal like
WFDC2 WAP four-disulfide core domain 2
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)