BRD-U60236422_WH-4-025_MCF10A_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-U60236422_WH-4-025_MCF10A_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASPN asporin
ASS1 argininosuccinate synthase 1
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BLVRB biliverdin reductase B
CAPN1 calpain 1, (mu/I) large subunit
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CFB complement factor B
CLDN10 claudin 10
CLDN7 claudin 7
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTSK cathepsin K
DBN1 drebrin 1
DCN decorin
DEFB1 defensin, beta 1
EFNA1 ephrin-A1
FAM134B family with sequence similarity 134, member B
FBLN1 fibulin 1
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GUSBP11 glucuronidase, beta pseudogene 11
HIST1H2AC histone cluster 1, H2ac
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP6 insulin-like growth factor binding protein 6
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KLK10 kallikrein-related peptidase 10
KRT16 keratin 16, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LCN2 lipocalin 2
LOXL1 lysyl oxidase-like 1
MME membrane metallo-endopeptidase
MUC1 mucin 1, cell surface associated
MUC4 mucin 4, cell surface associated
MXRA5 matrix-remodelling associated 5
NAMPT nicotinamide phosphoribosyltransferase
NARFL nuclear prelamin A recognition factor-like
NMU neuromedin U
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PCOLCE procollagen C-endopeptidase enhancer
PDZK1IP1 PDZK1 interacting protein 1
PI3 peptidase inhibitor 3, skin-derived
PPL periplakin
PRR15L proline rich 15-like
RAB25 RAB25, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
S100A4 S100 calcium binding protein A4
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFTPB surfactant protein B
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
SPON1 spondin 1, extracellular matrix protein
SPP1 secreted phosphoprotein 1
SPRR1B small proline-rich protein 1B
SYNE2 spectrin repeat containing, nuclear envelope 2
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
THY1 Thy-1 cell surface antigen
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
YPEL5 yippee-like 5 (Drosophila)
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ALB albumin
APOB apolipoprotein B
APOH apolipoprotein H (beta-2-glycoprotein I)
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CDC25A cell division cycle 25A
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CYR61 cysteine-rich, angiogenic inducer, 61
DDAH1 dimethylarginine dimethylaminohydrolase 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLC1 DLC1 Rho GTPase activating protein
DUSP5 dual specificity phosphatase 5
ELF5 E74-like factor 5 (ets domain transcription factor)
ELOVL2 ELOVL fatty acid elongase 2
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GLIPR1 GLI pathogenesis-related 1
HHEX hematopoietically expressed homeobox
HIST1H4C histone cluster 1, H4c
HMGA2 high mobility group AT-hook 2
IGFBP3 insulin-like growth factor binding protein 3
MATN2 matrilin 2
MT1F metallothionein 1F
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
PEG10 paternally expressed 10
PLIN2 perilipin 2
PLK1 polo-like kinase 1
PTX3 pentraxin 3, long
RPS11 ribosomal protein S11
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SGCE sarcoglycan, epsilon
SPRY2 sprouty homolog 2 (Drosophila)
TF transferrin
THBS1 thrombospondin 1
TKTL1 transketolase-like 1
TMEM158 transmembrane protein 158 (gene/pseudogene)