BRD-U60236422_WH-4-025_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

177 genes differentially expressed following the BRD-U60236422_WH-4-025_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AP3D1 adaptor-related protein complex 3, delta 1 subunit
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATRX alpha thalassemia/mental retardation syndrome X-linked
BCL6 B-cell CLL/lymphoma 6
BEX4 brain expressed, X-linked 4
C1RL complement component 1, r subcomponent-like
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN1 calpain 1, (mu/I) large subunit
CCNG2 cyclin G2
CELF2 CUGBP, Elav-like family member 2
CFB complement factor B
CLU clusterin
CP ceruloplasmin (ferroxidase)
CPM carboxypeptidase M
CTSB cathepsin B
CTSL cathepsin L
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEFB1 defensin, beta 1
DPP4 dipeptidyl-peptidase 4
EFNA1 ephrin-A1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FOXO4 forkhead box O4
FXYD3 FXYD domain containing ion transport regulator 3
GLS glutaminase
GOLGA8A golgin A8 family, member A
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GRN granulin
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IDS iduronate 2-sulfatase
IL6R interleukin 6 receptor
IRF9 interferon regulatory factor 9
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KLHL24 kelch-like family member 24
LAMP2 lysosomal-associated membrane protein 2
LGALS8 lectin, galactoside-binding, soluble, 8
MEIS2 Meis homeobox 2
MLPH melanophilin
MPPED2 metallophosphoesterase domain containing 2
MUC1 mucin 1, cell surface associated
MVP major vault protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPIPB3 nuclear pore complex interacting protein family, member B3
NUPR1 nuclear protein, transcriptional regulator, 1
OBSL1 obscurin-like 1
PBX1 pre-B-cell leukemia homeobox 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PEG3 paternally expressed 3
PERP PERP, TP53 apoptosis effector
PLD3 phospholipase D family, member 3
PSAP prosaposin
RHOQ ras homolog family member Q
RPL31 ribosomal protein L31
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SEPP1 selenoprotein P, plasma, 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
SPP1 secreted phosphoprotein 1
TAPBP TAP binding protein (tapasin)
TCTA T-cell leukemia translocation altered
TIMP3 TIMP metallopeptidase inhibitor 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TTC39A tetratricopeptide repeat domain 39A
TXNIP thioredoxin interacting protein
UBXN4 UBX domain protein 4
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGDH UDP-glucose 6-dehydrogenase
VDAC1 voltage-dependent anion channel 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADGRG2 adhesion G protein-coupled receptor G2
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BTG3 BTG family, member 3
CCNA2 cyclin A2
CCND1 cyclin D1
CCP110 centriolar coiled coil protein 110kDa
CD44 CD44 molecule (Indian blood group)
CDC20 cell division cycle 20
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CLTB clathrin, light chain B
COL5A1 collagen, type V, alpha 1
CXCL14 chemokine (C-X-C motif) ligand 14
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
G0S2 G0/G1 switch 2
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HELLS helicase, lymphoid-specific
HMGB2 high mobility group box 2
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM2 intercellular adhesion molecule 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGL immunoglobulin lambda locus
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MGP matrix Gla protein
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MSH2 mutS homolog 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFIB nuclear factor I/B
NMU neuromedin U
NUP93 nucleoporin 93kDa
PBK PDZ binding kinase
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PPARG peroxisome proliferator-activated receptor gamma
PRC1 protein regulator of cytokinesis 1
PRSS3 protease, serine, 3
PSPH phosphoserine phosphatase
PTMA prothymosin, alpha
RACGAP1 Rac GTPase activating protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RRM1 ribonucleotide reductase M1
SAP30 Sin3A-associated protein, 30kDa
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SRGN serglycin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAGLN transgelin
TFDP1 transcription factor Dp-1
TFRC transferrin receptor
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TTK TTK protein kinase
TUBB2A tubulin, beta 2A class IIa
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
USP1 ubiquitin specific peptidase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)